Multiple myeloma presenting as bilateral breast lumps in pregnant woman
Background Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast. Case report We describe the case of a...
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| Veröffentlicht in: | International journal of hematology 2013-10, Vol.98 (4), p.487-490 |
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| container_title | International journal of hematology |
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| creator | Bouzguenda, Racem Khanfir, Afef Toumi, Nabil Chaaben, Kais Hentati, Yosr Ayadi, Lobna Feki, Wiem Daoud, Jamel Frikha, Mounir |
| description | Background
Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast.
Case report
We describe the case of a 39-year-old woman diagnosed with an IgG lambda light-chain MM (Durie-Salmon stage IIIA, International Staging System II) in the 26th week of pregnancy, presenting with bilateral breast lumps. Dexamethasone (20 mg/m
2
/day on days 1–4, 9–12, and 17–20) was given as an induction agent to decrease tumor mass during pregnancy. Adverse response to dexamethasone was minor with excellent tolerance. A healthy baby was delivered at week 34 of gestation.
Conclusion
Breast nodules revealing MM are extremely rare. Clinical and radiological features are atypical. Presentation during pregnancy is extremely rare, making anti-MM treatment potentially challenging. |
| doi_str_mv | 10.1007/s12185-013-1420-y |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1444392479</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1444392479</sourcerecordid><originalsourceid>FETCH-LOGICAL-c426t-f3413ba4139a905b5f506c804b0635f91b81b78e1060e729d9e5fc9b66d19b563</originalsourceid><addsrcrecordid>eNp10E9LHDEYBvBQKnW1_QC9lIFS8DL6vvk7ORaxKihe7Dkks5llJJMZkxnKfnuz7FZLwUtyyO958_IQ8hXhHAHURUaKjagBWY2cQr39QFbYSFEzpfhHsgJNRS0UwjE5yfkJABVw9YkcU6aVEBRW5Pp-CXM_BV8NWx_GwVZT8tnHuY-byubK9cHOPtlQueRtnquwDFOu-rhzm2jjXP0pqfiZHHU2ZP_lcJ-S37-uHi9v6ruH69vLn3d1y6mc645xZM6WQ1sNwolOgGwb4A4kE51G16BTjUeQ4BXVa-1F12on5Rq1E5KdkrP93CmNz4vPsxn63PoQbPTjkg1yzpmmXOlCv_9Hn8YlxbLdTjGJiqIqCveqTWPOyXdmSv1g09YgmF3LZt-yKS2bXctmWzLfDpMXN_j1a-JvrQX8OACbWxu6ZGPb5zenNEDT0OLo3uXyFDc-_bPiu7-_AJVxk20</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443617217</pqid></control><display><type>article</type><title>Multiple myeloma presenting as bilateral breast lumps in pregnant woman</title><source>MEDLINE</source><source>SpringerLink Journals</source><creator>Bouzguenda, Racem ; Khanfir, Afef ; Toumi, Nabil ; Chaaben, Kais ; Hentati, Yosr ; Ayadi, Lobna ; Feki, Wiem ; Daoud, Jamel ; Frikha, Mounir</creator><creatorcontrib>Bouzguenda, Racem ; Khanfir, Afef ; Toumi, Nabil ; Chaaben, Kais ; Hentati, Yosr ; Ayadi, Lobna ; Feki, Wiem ; Daoud, Jamel ; Frikha, Mounir</creatorcontrib><description>Background
Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast.
Case report
We describe the case of a 39-year-old woman diagnosed with an IgG lambda light-chain MM (Durie-Salmon stage IIIA, International Staging System II) in the 26th week of pregnancy, presenting with bilateral breast lumps. Dexamethasone (20 mg/m
2
/day on days 1–4, 9–12, and 17–20) was given as an induction agent to decrease tumor mass during pregnancy. Adverse response to dexamethasone was minor with excellent tolerance. A healthy baby was delivered at week 34 of gestation.
Conclusion
Breast nodules revealing MM are extremely rare. Clinical and radiological features are atypical. Presentation during pregnancy is extremely rare, making anti-MM treatment potentially challenging.</description><identifier>ISSN: 0925-5710</identifier><identifier>EISSN: 1865-3774</identifier><identifier>DOI: 10.1007/s12185-013-1420-y</identifier><identifier>PMID: 23975520</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Adult ; Biological and medical sciences ; Biopsy ; Bone Marrow - pathology ; Breast - pathology ; Case Report ; Dexamethasone - therapeutic use ; Female ; Hematologic and hematopoietic diseases ; Hematology ; Humans ; Immunodeficiencies. Immunoglobulinopathies ; Immunoglobulinopathies ; Immunopathology ; Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis ; Magnetic Resonance Imaging ; Medical sciences ; Medicine ; Medicine & Public Health ; Multiple Myeloma - diagnosis ; Multiple Myeloma - pathology ; Multiple Myeloma - therapy ; Neoplasm Staging ; Oncology ; Pelvis - pathology ; Pregnancy ; Pregnancy Outcome ; Treatment Outcome ; Ultrasonography, Doppler, Color</subject><ispartof>International journal of hematology, 2013-10, Vol.98 (4), p.487-490</ispartof><rights>The Japanese Society of Hematology 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c426t-f3413ba4139a905b5f506c804b0635f91b81b78e1060e729d9e5fc9b66d19b563</citedby><cites>FETCH-LOGICAL-c426t-f3413ba4139a905b5f506c804b0635f91b81b78e1060e729d9e5fc9b66d19b563</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s12185-013-1420-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s12185-013-1420-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27900882$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23975520$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Bouzguenda, Racem</creatorcontrib><creatorcontrib>Khanfir, Afef</creatorcontrib><creatorcontrib>Toumi, Nabil</creatorcontrib><creatorcontrib>Chaaben, Kais</creatorcontrib><creatorcontrib>Hentati, Yosr</creatorcontrib><creatorcontrib>Ayadi, Lobna</creatorcontrib><creatorcontrib>Feki, Wiem</creatorcontrib><creatorcontrib>Daoud, Jamel</creatorcontrib><creatorcontrib>Frikha, Mounir</creatorcontrib><title>Multiple myeloma presenting as bilateral breast lumps in pregnant woman</title><title>International journal of hematology</title><addtitle>Int J Hematol</addtitle><addtitle>Int J Hematol</addtitle><description>Background
Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast.
Case report
We describe the case of a 39-year-old woman diagnosed with an IgG lambda light-chain MM (Durie-Salmon stage IIIA, International Staging System II) in the 26th week of pregnancy, presenting with bilateral breast lumps. Dexamethasone (20 mg/m
2
/day on days 1–4, 9–12, and 17–20) was given as an induction agent to decrease tumor mass during pregnancy. Adverse response to dexamethasone was minor with excellent tolerance. A healthy baby was delivered at week 34 of gestation.
Conclusion
Breast nodules revealing MM are extremely rare. Clinical and radiological features are atypical. Presentation during pregnancy is extremely rare, making anti-MM treatment potentially challenging.</description><subject>Adult</subject><subject>Biological and medical sciences</subject><subject>Biopsy</subject><subject>Bone Marrow - pathology</subject><subject>Breast - pathology</subject><subject>Case Report</subject><subject>Dexamethasone - therapeutic use</subject><subject>Female</subject><subject>Hematologic and hematopoietic diseases</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immunodeficiencies. Immunoglobulinopathies</subject><subject>Immunoglobulinopathies</subject><subject>Immunopathology</subject><subject>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</subject><subject>Magnetic Resonance Imaging</subject><subject>Medical sciences</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Multiple Myeloma - diagnosis</subject><subject>Multiple Myeloma - pathology</subject><subject>Multiple Myeloma - therapy</subject><subject>Neoplasm Staging</subject><subject>Oncology</subject><subject>Pelvis - pathology</subject><subject>Pregnancy</subject><subject>Pregnancy Outcome</subject><subject>Treatment Outcome</subject><subject>Ultrasonography, Doppler, Color</subject><issn>0925-5710</issn><issn>1865-3774</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNp10E9LHDEYBvBQKnW1_QC9lIFS8DL6vvk7ORaxKihe7Dkks5llJJMZkxnKfnuz7FZLwUtyyO958_IQ8hXhHAHURUaKjagBWY2cQr39QFbYSFEzpfhHsgJNRS0UwjE5yfkJABVw9YkcU6aVEBRW5Pp-CXM_BV8NWx_GwVZT8tnHuY-byubK9cHOPtlQueRtnquwDFOu-rhzm2jjXP0pqfiZHHU2ZP_lcJ-S37-uHi9v6ruH69vLn3d1y6mc645xZM6WQ1sNwolOgGwb4A4kE51G16BTjUeQ4BXVa-1F12on5Rq1E5KdkrP93CmNz4vPsxn63PoQbPTjkg1yzpmmXOlCv_9Hn8YlxbLdTjGJiqIqCveqTWPOyXdmSv1g09YgmF3LZt-yKS2bXctmWzLfDpMXN_j1a-JvrQX8OACbWxu6ZGPb5zenNEDT0OLo3uXyFDc-_bPiu7-_AJVxk20</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Bouzguenda, Racem</creator><creator>Khanfir, Afef</creator><creator>Toumi, Nabil</creator><creator>Chaaben, Kais</creator><creator>Hentati, Yosr</creator><creator>Ayadi, Lobna</creator><creator>Feki, Wiem</creator><creator>Daoud, Jamel</creator><creator>Frikha, Mounir</creator><general>Springer Japan</general><general>Springer</general><general>Springer Nature B.V</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>C1K</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Multiple myeloma presenting as bilateral breast lumps in pregnant woman</title><author>Bouzguenda, Racem ; Khanfir, Afef ; Toumi, Nabil ; Chaaben, Kais ; Hentati, Yosr ; Ayadi, Lobna ; Feki, Wiem ; Daoud, Jamel ; Frikha, Mounir</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c426t-f3413ba4139a905b5f506c804b0635f91b81b78e1060e729d9e5fc9b66d19b563</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Biological and medical sciences</topic><topic>Biopsy</topic><topic>Bone Marrow - pathology</topic><topic>Breast - pathology</topic><topic>Case Report</topic><topic>Dexamethasone - therapeutic use</topic><topic>Female</topic><topic>Hematologic and hematopoietic diseases</topic><topic>Hematology</topic><topic>Humans</topic><topic>Immunodeficiencies. Immunoglobulinopathies</topic><topic>Immunoglobulinopathies</topic><topic>Immunopathology</topic><topic>Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis</topic><topic>Magnetic Resonance Imaging</topic><topic>Medical sciences</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Multiple Myeloma - diagnosis</topic><topic>Multiple Myeloma - pathology</topic><topic>Multiple Myeloma - therapy</topic><topic>Neoplasm Staging</topic><topic>Oncology</topic><topic>Pelvis - pathology</topic><topic>Pregnancy</topic><topic>Pregnancy Outcome</topic><topic>Treatment Outcome</topic><topic>Ultrasonography, Doppler, Color</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Bouzguenda, Racem</creatorcontrib><creatorcontrib>Khanfir, Afef</creatorcontrib><creatorcontrib>Toumi, Nabil</creatorcontrib><creatorcontrib>Chaaben, Kais</creatorcontrib><creatorcontrib>Hentati, Yosr</creatorcontrib><creatorcontrib>Ayadi, Lobna</creatorcontrib><creatorcontrib>Feki, Wiem</creatorcontrib><creatorcontrib>Daoud, Jamel</creatorcontrib><creatorcontrib>Frikha, Mounir</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of hematology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Bouzguenda, Racem</au><au>Khanfir, Afef</au><au>Toumi, Nabil</au><au>Chaaben, Kais</au><au>Hentati, Yosr</au><au>Ayadi, Lobna</au><au>Feki, Wiem</au><au>Daoud, Jamel</au><au>Frikha, Mounir</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Multiple myeloma presenting as bilateral breast lumps in pregnant woman</atitle><jtitle>International journal of hematology</jtitle><stitle>Int J Hematol</stitle><addtitle>Int J Hematol</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>98</volume><issue>4</issue><spage>487</spage><epage>490</epage><pages>487-490</pages><issn>0925-5710</issn><eissn>1865-3774</eissn><abstract>Background
Multiple myeloma (MM) is a systemic disease in the elderly. Its incidence in patients younger than 40 years old and especially in pregnant women is extremely rare. MM may involve extraosseous sites, and only in rare cases it is observed in the breast.
Case report
We describe the case of a 39-year-old woman diagnosed with an IgG lambda light-chain MM (Durie-Salmon stage IIIA, International Staging System II) in the 26th week of pregnancy, presenting with bilateral breast lumps. Dexamethasone (20 mg/m
2
/day on days 1–4, 9–12, and 17–20) was given as an induction agent to decrease tumor mass during pregnancy. Adverse response to dexamethasone was minor with excellent tolerance. A healthy baby was delivered at week 34 of gestation.
Conclusion
Breast nodules revealing MM are extremely rare. Clinical and radiological features are atypical. Presentation during pregnancy is extremely rare, making anti-MM treatment potentially challenging.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>23975520</pmid><doi>10.1007/s12185-013-1420-y</doi><tpages>4</tpages></addata></record> |
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| subjects | Adult Biological and medical sciences Biopsy Bone Marrow - pathology Breast - pathology Case Report Dexamethasone - therapeutic use Female Hematologic and hematopoietic diseases Hematology Humans Immunodeficiencies. Immunoglobulinopathies Immunoglobulinopathies Immunopathology Leukemias. Malignant lymphomas. Malignant reticulosis. Myelofibrosis Magnetic Resonance Imaging Medical sciences Medicine Medicine & Public Health Multiple Myeloma - diagnosis Multiple Myeloma - pathology Multiple Myeloma - therapy Neoplasm Staging Oncology Pelvis - pathology Pregnancy Pregnancy Outcome Treatment Outcome Ultrasonography, Doppler, Color |
| title | Multiple myeloma presenting as bilateral breast lumps in pregnant woman |
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