Role of phospholemman and the 70 kDa inhibitor protein in regulating Na+/K+ ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation

Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na+/K+ ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70 kDa inhibitor protein of Na+/K+ ATPase. Although phosp...

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Veröffentlicht in:	FEBS letters 2013-11, Vol.587 (21), p.3535-3540
Hauptverfasser:	Dey, Kuntal, Rahaman, Sayed Modinur, Chakraborti, Tapati, Chakraborti, Sajal
Format:	Artikel
Sprache:	eng
Schlagworte:	15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Animals Cattle Inhibitor protein Membrane Proteins - metabolism Myocytes, Smooth Muscle - metabolism Na+/K+ ATPase Phospholemman Phosphoproteins - metabolism Protein Isoforms - metabolism Protein kinase Pulmonary Artery - enzymology Pulmonary Artery - metabolism Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism TxA2 U46619 Vasoconstrictor Agents - pharmacology
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