Role of phospholemman and the 70 kDa inhibitor protein in regulating Na+/K+ ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation
Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na+/K+ ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70 kDa inhibitor protein of Na+/K+ ATPase. Although phosp...
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Veröffentlicht in: | FEBS letters 2013-11, Vol.587 (21), p.3535-3540 |
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description | Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na+/K+ ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70 kDa inhibitor protein of Na+/K+ ATPase. Although phospholemman deglutathionylates the pump leading to its activation, the inhibitor is responsible for irreversible inhibition of Na+/K+ ATPase in an isoform specific manner during treatment of the cells with U46619.
Inhibition of Na+/K+ ATPase activity upon TxA2 mimetic U46619 stimulation.
Involvement of 70 kDa inhibitor protein under U46619 mediated oxidative stress.
Isoform specific inhibition Na+/K+ ATPase by oxidants. |
doi_str_mv | 10.1016/j.febslet.2013.09.011 |
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Inhibition of Na+/K+ ATPase activity upon TxA2 mimetic U46619 stimulation.
Involvement of 70 kDa inhibitor protein under U46619 mediated oxidative stress.
Isoform specific inhibition Na+/K+ ATPase by oxidants.</description><identifier>ISSN: 0014-5793</identifier><identifier>EISSN: 1873-3468</identifier><identifier>DOI: 10.1016/j.febslet.2013.09.011</identifier><identifier>PMID: 24055474</identifier><language>eng</language><publisher>England</publisher><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology ; Animals ; Cattle ; Inhibitor protein ; Membrane Proteins - metabolism ; Myocytes, Smooth Muscle - metabolism ; Na+/K+ ATPase ; Phospholemman ; Phosphoproteins - metabolism ; Protein Isoforms - metabolism ; Protein kinase ; Pulmonary Artery - enzymology ; Pulmonary Artery - metabolism ; Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors ; Sodium-Potassium-Exchanging ATPase - metabolism ; TxA2 ; U46619 ; Vasoconstrictor Agents - pharmacology</subject><ispartof>FEBS letters, 2013-11, Vol.587 (21), p.3535-3540</ispartof><rights>FEBS Letters 587 (2013) 1873-3468 © 2015 Federation of European Biochemical Societies</rights><rights>Copyright © 2013 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3740-5062f92b5b121413b9f1f395d8f7625152a706b405ba34d2b6b0e22f0d87f5373</citedby><cites>FETCH-LOGICAL-c3740-5062f92b5b121413b9f1f395d8f7625152a706b405ba34d2b6b0e22f0d87f5373</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1016%2Fj.febslet.2013.09.011$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1016%2Fj.febslet.2013.09.011$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24055474$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Dey, Kuntal</creatorcontrib><creatorcontrib>Rahaman, Sayed Modinur</creatorcontrib><creatorcontrib>Chakraborti, Tapati</creatorcontrib><creatorcontrib>Chakraborti, Sajal</creatorcontrib><title>Role of phospholemman and the 70 kDa inhibitor protein in regulating Na+/K+ ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation</title><title>FEBS letters</title><addtitle>FEBS Lett</addtitle><description>Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na+/K+ ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70 kDa inhibitor protein of Na+/K+ ATPase. Although phospholemman deglutathionylates the pump leading to its activation, the inhibitor is responsible for irreversible inhibition of Na+/K+ ATPase in an isoform specific manner during treatment of the cells with U46619.
Inhibition of Na+/K+ ATPase activity upon TxA2 mimetic U46619 stimulation.
Involvement of 70 kDa inhibitor protein under U46619 mediated oxidative stress.
Isoform specific inhibition Na+/K+ ATPase by oxidants.</description><subject>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</subject><subject>Animals</subject><subject>Cattle</subject><subject>Inhibitor protein</subject><subject>Membrane Proteins - metabolism</subject><subject>Myocytes, Smooth Muscle - metabolism</subject><subject>Na+/K+ ATPase</subject><subject>Phospholemman</subject><subject>Phosphoproteins - metabolism</subject><subject>Protein Isoforms - metabolism</subject><subject>Protein kinase</subject><subject>Pulmonary Artery - enzymology</subject><subject>Pulmonary Artery - metabolism</subject><subject>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</subject><subject>Sodium-Potassium-Exchanging ATPase - metabolism</subject><subject>TxA2</subject><subject>U46619</subject><subject>Vasoconstrictor Agents - pharmacology</subject><issn>0014-5793</issn><issn>1873-3468</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkd1u1DAQhSMEokvhEUC-RKqSjv_jy1JaiqgAQXtt2Ru76yWJl9gB7bvwsDjswjUXo9FYZ8746KuqlxgaDFicbxvvbOpdbghg2oBqAONH1Qq3ktaUifZxtQLArOZS0ZPqWUpbKHOL1dPqhDDgnEm2qn59ib1D0aPdJqZSvRsGMyIzdihvHJKAvr01KIybYEOOE9pNMbswlhc0uYe5NzmMD-ijOTv_cIYu7j6b5JBZ5_Aj5P0i2s39EEcz7ZGZsistDTHmDRrmtC6H167vE5rHzk3ongmBFUo5DH984_i8euJNn9yLYz-t7q-v7i5v6ttP795fXtzWayoZ1BwE8YpYbjHBDFOrPPZU8a71UhCOOTEShC2ZraGsI1ZYcIR46FrpOZX0tHp98C3pvs8uZT2EtHzNjC7OSWPGGFVYClak_CBdTzGlyXm9m8JQ8mkMegGjt_oIRi9gNChdwJS9V8cTsx1c92_rL4kiuDkIfobe7f_PVV9fvSFfF8oLZEwBhBJAfwPcqqFp</recordid><startdate>20131101</startdate><enddate>20131101</enddate><creator>Dey, Kuntal</creator><creator>Rahaman, Sayed Modinur</creator><creator>Chakraborti, Tapati</creator><creator>Chakraborti, Sajal</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131101</creationdate><title>Role of phospholemman and the 70 kDa inhibitor protein in regulating Na+/K+ ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation</title><author>Dey, Kuntal ; Rahaman, Sayed Modinur ; Chakraborti, Tapati ; Chakraborti, Sajal</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3740-5062f92b5b121413b9f1f395d8f7625152a706b405ba34d2b6b0e22f0d87f5373</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology</topic><topic>Animals</topic><topic>Cattle</topic><topic>Inhibitor protein</topic><topic>Membrane Proteins - metabolism</topic><topic>Myocytes, Smooth Muscle - metabolism</topic><topic>Na+/K+ ATPase</topic><topic>Phospholemman</topic><topic>Phosphoproteins - metabolism</topic><topic>Protein Isoforms - metabolism</topic><topic>Protein kinase</topic><topic>Pulmonary Artery - enzymology</topic><topic>Pulmonary Artery - metabolism</topic><topic>Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors</topic><topic>Sodium-Potassium-Exchanging ATPase - metabolism</topic><topic>TxA2</topic><topic>U46619</topic><topic>Vasoconstrictor Agents - pharmacology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Dey, Kuntal</creatorcontrib><creatorcontrib>Rahaman, Sayed Modinur</creatorcontrib><creatorcontrib>Chakraborti, Tapati</creatorcontrib><creatorcontrib>Chakraborti, Sajal</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>FEBS letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Dey, Kuntal</au><au>Rahaman, Sayed Modinur</au><au>Chakraborti, Tapati</au><au>Chakraborti, Sajal</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Role of phospholemman and the 70 kDa inhibitor protein in regulating Na+/K+ ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation</atitle><jtitle>FEBS letters</jtitle><addtitle>FEBS Lett</addtitle><date>2013-11-01</date><risdate>2013</risdate><volume>587</volume><issue>21</issue><spage>3535</spage><epage>3540</epage><pages>3535-3540</pages><issn>0014-5793</issn><eissn>1873-3468</eissn><abstract>Treatment of bovine pulmonary smooth muscle cells with U46619 inhibited the Na+/K+ ATPase activity in two parallel pathways: one of which is mediated via glutathionylation of the pump and the other by augmenting the inhibitory activity of the 70 kDa inhibitor protein of Na+/K+ ATPase. Although phospholemman deglutathionylates the pump leading to its activation, the inhibitor is responsible for irreversible inhibition of Na+/K+ ATPase in an isoform specific manner during treatment of the cells with U46619.
Inhibition of Na+/K+ ATPase activity upon TxA2 mimetic U46619 stimulation.
Involvement of 70 kDa inhibitor protein under U46619 mediated oxidative stress.
Isoform specific inhibition Na+/K+ ATPase by oxidants.</abstract><cop>England</cop><pmid>24055474</pmid><doi>10.1016/j.febslet.2013.09.011</doi><tpages>6</tpages></addata></record> |
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subjects | 15-Hydroxy-11 alpha,9 alpha-(epoxymethano)prosta-5,13-dienoic Acid - pharmacology Animals Cattle Inhibitor protein Membrane Proteins - metabolism Myocytes, Smooth Muscle - metabolism Na+/K+ ATPase Phospholemman Phosphoproteins - metabolism Protein Isoforms - metabolism Protein kinase Pulmonary Artery - enzymology Pulmonary Artery - metabolism Sodium-Potassium-Exchanging ATPase - antagonists & inhibitors Sodium-Potassium-Exchanging ATPase - metabolism TxA2 U46619 Vasoconstrictor Agents - pharmacology |
title | Role of phospholemman and the 70 kDa inhibitor protein in regulating Na+/K+ ATPase activity in pulmonary artery smooth muscle cells under U46619 stimulation |
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