Synthesis of combretastatin A4 analogues on steroidal framework and their anti-breast cancer activity

Combretastatin A4 analogues have been synthesized on steroidal framework. Analogue 22 exhibited potent anti-breast cancer activity through strong tubulin polymerisation inhibition activity and was found to be non-toxic in Swiss albino mice. [Display omitted] ▶ Combretastatin A4 analogues on steroida...

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Veröffentlicht in:	The Journal of steroid biochemistry and molecular biology 2013-09, Vol.137, p.332-344
Hauptverfasser:	Parihar, Swati, Kumar, Amit, Chaturvedi, Amit K., Sachan, Naresh Kumar, Luqman, Suaib, Changkija, Bendangla, Manohar, Murli, Prakash, Om, Chanda, D., Khan, Feroz, Chanotiya, C.S., Shanker, Karuna, Dwivedi, Anila, Konwar, Rituraj, Negi, Arvind S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute oral toxicity Animals Antiestrogenicity Breast cancer Breast Neoplasms - pathology Cell Line, Tumor Combretastatin A4 Estrogenicity Female Humans Magnetic Resonance Spectroscopy Mice Rats Rats, Sprague-Dawley Spectrometry, Mass, Electrospray Ionization Steroids - chemistry Stilbenes - chemical synthesis Stilbenes - chemistry Stilbenes - pharmacology Tubulin polymerization inhibition
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