Cardiomyocyte-specific overexpression of human stem cell factor protects against myocardial ischemia and reperfusion injury

Abstract Background Cardiomyocyte-specific overexpression of human membrane-associated stem cell factor (hSCF) improves cardiac function post-myocardial infarction. However, whether hSCF overexpression protects the heart from ischemia and reperfusion (I/R) injury is unknown. We aimed to investigate...

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Veröffentlicht in:	International journal of cardiology 2013-10, Vol.168 (4), p.3486-3494
Hauptverfasser:	Xiang, Fu-Li, Lu, Xiangru, Liu, Yin, Feng, Qingping
Format:	Artikel
Sprache:	eng
Schlagworte:	Akt Animals Biological and medical sciences Cardiology. Vascular system Cardiotonic Agents - metabolism Cardiovascular Coronary heart disease Gene Expression Regulation Heart Humans Ischemia/reperfusion injury Male Medical sciences Mice Mice, Inbred C57BL Mice, Inbred CBA Mice, Transgenic Myocardial Ischemia - genetics Myocardial Ischemia - metabolism Myocardial Ischemia - prevention & control Myocardial Reperfusion Injury - genetics Myocardial Reperfusion Injury - metabolism Myocardial Reperfusion Injury - prevention & control Myocarditis. Cardiomyopathies Myocytes, Cardiac - metabolism Myocytes, Cardiac - pathology Stem cell factor Stem Cell Factor - biosynthesis Stem Cell Factor - genetics
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