Anti-platelet therapy in the prevention of hepatitis B virus-associated hepatocellular carcinoma

Summary Previous studies in mouse models of self-limited viral hepatitis showed that platelets contribute to acute liver damage by promoting the intrahepatic accumulation of virus-specific CD8 T cells and, secondarily, virus-non-specific inflammatory cells. Built on these observations, a recent prec...

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Veröffentlicht in:	Journal of hepatology 2013-11, Vol.59 (5), p.1135-1138
Hauptverfasser:	Sitia, Giovanni, Iannacone, Matteo, Guidotti, Luca G
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-platelet drugs Aspirin - pharmacology Aspirin - therapeutic use Blood Platelets - drug effects Blood Platelets - pathology Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - prevention & control Carcinoma, Hepatocellular - virology CD8 T cells CD8-Positive T-Lymphocytes - pathology Cell Proliferation - drug effects Disease Models, Animal Gastroenterology and Hepatology Hepatitis B virus Hepatitis B, Chronic - complications Hepatitis B, Chronic - pathology Hepatocellular carcinoma Humans Liver Neoplasms - pathology Liver Neoplasms - prevention & control Liver Neoplasms - virology Mice Platelet Aggregation Inhibitors - pharmacology Platelet Aggregation Inhibitors - therapeutic use Platelets Ticlopidine - analogs & derivatives Ticlopidine - pharmacology Ticlopidine - therapeutic use Viral hepatitis
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