Genetic Link between Heme Oxygenase and the Signaling Pathway of DNA Damage in Drosophila Melanogaster

Heme oxygenase (HO) is a rate-limiting step of heme degradation, which catalyzes the conversion of heme into biliverdin, iron, and CO. HO has been characterized in microorganisms, insects, plants, and mammals. The mammalian enzyme participates in adaptive and protective responses to oxidative stress...

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Veröffentlicht in:	The Tohoku Journal of Experimental Medicine 2013, Vol.231(2), pp.117-125
Hauptverfasser:	Ida, Hiroyuki, Suyari, Osamu, Shimamura, Mai, Tai, Tran Tien, Yamaguchi, Masamitsu, Taketani, Shigeru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Animals, Genetically Modified ataxia-telangiectasia mutated Bromodeoxyuridine Cell Cycle - genetics Cell Cycle - physiology Compound Eye, Arthropod - abnormalities Compound Eye, Arthropod - growth & development Crosses, Genetic DNA damage DNA Damage - genetics DNA Damage - physiology Drosophila melanogaster Drosophila melanogaster - enzymology Drosophila melanogaster - genetics Drosophila melanogaster - growth & development Gene Knockdown Techniques genetic interaction HEK293 Cells heme oxygenase Heme Oxygenase (Decyclizing) - genetics Heme Oxygenase (Decyclizing) - metabolism Humans Imaginal Discs - growth & development Imaginal Discs - metabolism Imaginal Discs - ultrastructure Larva - enzymology Larva - growth & development Microscopy, Electron, Scanning Reactive Oxygen Species RNA Interference RNA, Small Interfering - genetics Signal Transduction - genetics Signal Transduction - physiology
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