FosPeg® PDT alters the EBV miRNAs and LMP1 protein expression in EBV positive nasopharyngeal carcinoma cells

•FosPeg® is effective to EBV positive and EBV negative NPC cells by inducing apoptosis.•FosPeg® could suppress the expression of miRNAs BART 1-5p, BART 16 and BART 17-5p.•FosPeg® could induce LMP1 mRNA and protein expression in EBV positive c666-1 cells.•EBV-miRNAs, LMP1 mRNA and protein could be po...

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Veröffentlicht in:	Journal of photochemistry and photobiology. B, Biology Biology, 2013-10, Vol.127, p.114-122
Hauptverfasser:	Wu, Ricky W.K., Chu, Ellie S.M., Huang, Zheng, Xu, C.S., IP, C.W., Yow, Christine M.N.
Format:	Artikel
Sprache:	eng
Schlagworte:	antineoplastic agents carcinogenesis carcinoma Cell Cycle - drug effects Cell Cycle - radiation effects Cell Line, Tumor Chemistry, Pharmaceutical dose response Dose-Response Relationship, Drug EBV miRNAs FosPeg® PDT gene expression regulation Gene Expression Regulation, Neoplastic - drug effects Gene Expression Regulation, Neoplastic - radiation effects head Herpesvirus 4, Human - genetics Herpesvirus 4, Human - physiology Human herpesvirus 4 Humans in vitro studies Intracellular Space - drug effects Intracellular Space - metabolism Intracellular Space - radiation effects lethal dose 50 Liposomes LMP1 protein membrane proteins Mesoporphyrins - administration & dosage Mesoporphyrins - chemistry Mesoporphyrins - metabolism Mesoporphyrins - pharmacology Mesoporphyrins - therapeutic use messenger RNA microRNA MicroRNAs - genetics Nasopharyngeal Neoplasms - pathology Nasopharyngeal Neoplasms - virology neck neoplasm cells oncogene proteins photobiology photochemistry Photochemotherapy Polyethylene Glycols - chemistry protein synthesis proteins quantitative polymerase chain reaction RNA, Viral - genetics therapeutics Viral Matrix Proteins - genetics Viral Matrix Proteins - metabolism viral proteins Western blotting
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