Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation
Abstract Background Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties. Our aim was to assess whether vitamin E is assoc...
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| Veröffentlicht in: | International journal of cardiology 2013-10, Vol.168 (4), p.3241-3247 |
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| creator | Cangemi, Roberto Pignatelli, Pasquale Carnevale, Roberto Corazza, Gino Roberto Pastori, Daniele Farcomeni, Alessio Basili, Stefania Davì, Giovanni Ferro, Domenico Hiatt, William R Licata, Giuseppe Lip, Gregory Y.H Loffredo, Lorenzo Mannucci, Pier Mannuccio Vestri, Annarita Violi, Francesco |
| description | Abstract Background Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties. Our aim was to assess whether vitamin E is associated with cardiovascular events in patients with non-valvular atrial fibrillation. Methods Serum levels of cholesterol-adjusted vitamin E were measured in 1012 patients with non-valvular atrial fibrillation. Patients were followed for a mean time of 27.0 months, and cardiovascular events, such as cardiovascular death and fatal and nonfatal stroke or myocardial infarction, were recorded. Results During the follow-up period, cardiovascular events occurred in 109 (11%) patients (18 fatal and 14 nonfatal myocardial infarction; 13 fatal and 19 nonfatal ischemic strokes; 45 cardiovascular deaths). Lower vitamin E serum levels were found in patients who experienced cardiovascular events compared to those who did not (3.8 ± 1.2 vs. 4.4 ± 1.8 μmol/mmol cholesterol; p < 0.001). Using a Cox proportional hazard model, age, diabetes, history of stroke and myocardial infarction and vitamin E serum levels (HR 0.77; 95% CI: 0.67–0.89; p = 0.001) independently predicted cardiovascular events. Patients with vitamin E < 4.2 μmol/mmol cholesterol (median values) had an increased risk of cardiovascular events (HR 1.87; 95% CI: 1.25–2.80: p = 0.002). Conclusions Low vitamin E serum levels are associated with an increased risk of cardiovascular events in patients with non-valvular atrial fibrillation. |
| doi_str_mv | 10.1016/j.ijcard.2013.04.142 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443997488</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0167527313007894</els_id><sourcerecordid>1443997488</sourcerecordid><originalsourceid>FETCH-LOGICAL-c447t-5f49d49c41fda1a3d8e4ce2069c33c68f0b3b7bb1d02d84e2a9112221757ef273</originalsourceid><addsrcrecordid>eNqFks1u1DAUhS0EokPhDRDyBolNgv9mHG-Q0Kj8SJVY0K4tx75RHZx4sJOgPgGvXWdmAIlNV76L79x7fc5F6DUlNSV0976vfW9NcjUjlNdE1FSwJ2hDGykqKrfiKdoUTFZbJvkFepFzTwgRSjXP0QXjuy1tmNyg3_u7GCBPkGKojOvnUjq8-MkMfsRXOEOaBxxggZCxSYBNztF6s1K__HSH1xV8XEy2czAJF3CcMi7ag5n8sT5iYxyrxYTlCJkpeRNw59vkQyhcHF-iZ50JGV6d30t0--nqZv-luv72-ev-43VlhZBTte2EckJZQTtnqOGuAWGBkZ2ynNtd05GWt7JtqSPMNQKYUZQyxoohErrixCV6d-p7SPHnXD6uB58tlC1GiHPWVAiulBRNU1BxQm2KOSfo9CH5waR7TYleI9C9PkWg1wg0EUXNiuzNecLcDuD-iv54XoC3Z6CYZkKXzGh9_sdJRZSgpHAfTlyxHhYPSWdbHLXgfAI7aRf9Y5v838AGP_oy8wfcQ-7jnMbitaY6M0309_Vc1muhnBDZKMEfALDBvmI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443997488</pqid></control><display><type>article</type><title>Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><creator>Cangemi, Roberto ; Pignatelli, Pasquale ; Carnevale, Roberto ; Corazza, Gino Roberto ; Pastori, Daniele ; Farcomeni, Alessio ; Basili, Stefania ; Davì, Giovanni ; Ferro, Domenico ; Hiatt, William R ; Licata, Giuseppe ; Lip, Gregory Y.H ; Loffredo, Lorenzo ; Mannucci, Pier Mannuccio ; Vestri, Annarita ; Violi, Francesco</creator><creatorcontrib>Cangemi, Roberto ; Pignatelli, Pasquale ; Carnevale, Roberto ; Corazza, Gino Roberto ; Pastori, Daniele ; Farcomeni, Alessio ; Basili, Stefania ; Davì, Giovanni ; Ferro, Domenico ; Hiatt, William R ; Licata, Giuseppe ; Lip, Gregory Y.H ; Loffredo, Lorenzo ; Mannucci, Pier Mannuccio ; Vestri, Annarita ; Violi, Francesco ; in collaboration with the ARA PACIS study group ; ARA PACIS study group</creatorcontrib><description>Abstract Background Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties. Our aim was to assess whether vitamin E is associated with cardiovascular events in patients with non-valvular atrial fibrillation. Methods Serum levels of cholesterol-adjusted vitamin E were measured in 1012 patients with non-valvular atrial fibrillation. Patients were followed for a mean time of 27.0 months, and cardiovascular events, such as cardiovascular death and fatal and nonfatal stroke or myocardial infarction, were recorded. Results During the follow-up period, cardiovascular events occurred in 109 (11%) patients (18 fatal and 14 nonfatal myocardial infarction; 13 fatal and 19 nonfatal ischemic strokes; 45 cardiovascular deaths). Lower vitamin E serum levels were found in patients who experienced cardiovascular events compared to those who did not (3.8 ± 1.2 vs. 4.4 ± 1.8 μmol/mmol cholesterol; p < 0.001). Using a Cox proportional hazard model, age, diabetes, history of stroke and myocardial infarction and vitamin E serum levels (HR 0.77; 95% CI: 0.67–0.89; p = 0.001) independently predicted cardiovascular events. Patients with vitamin E < 4.2 μmol/mmol cholesterol (median values) had an increased risk of cardiovascular events (HR 1.87; 95% CI: 1.25–2.80: p = 0.002). Conclusions Low vitamin E serum levels are associated with an increased risk of cardiovascular events in patients with non-valvular atrial fibrillation.</description><identifier>ISSN: 0167-5273</identifier><identifier>EISSN: 1874-1754</identifier><identifier>DOI: 10.1016/j.ijcard.2013.04.142</identifier><identifier>PMID: 23651827</identifier><identifier>CODEN: IJCDD5</identifier><language>eng</language><publisher>Shannon: Elsevier Ireland Ltd</publisher><subject>Aged ; Aged, 80 and over ; Atrial fibrillation ; Atrial Fibrillation - blood ; Atrial Fibrillation - diagnosis ; Biological and medical sciences ; Biomarkers - blood ; Cardiac dysrhythmias ; Cardiology. Vascular system ; Cardiovascular ; Cardiovascular events ; Cholesterol - blood ; Disorders of blood lipids. Hyperlipoproteinemia ; Female ; Follow-Up Studies ; Heart ; Humans ; Male ; Medical sciences ; Metabolic diseases ; Middle Aged ; Prospective Studies ; Vitamin E ; Vitamin E - blood</subject><ispartof>International journal of cardiology, 2013-10, Vol.168 (4), p.3241-3247</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c447t-5f49d49c41fda1a3d8e4ce2069c33c68f0b3b7bb1d02d84e2a9112221757ef273</citedby><cites>FETCH-LOGICAL-c447t-5f49d49c41fda1a3d8e4ce2069c33c68f0b3b7bb1d02d84e2a9112221757ef273</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.ijcard.2013.04.142$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27909410$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23651827$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cangemi, Roberto</creatorcontrib><creatorcontrib>Pignatelli, Pasquale</creatorcontrib><creatorcontrib>Carnevale, Roberto</creatorcontrib><creatorcontrib>Corazza, Gino Roberto</creatorcontrib><creatorcontrib>Pastori, Daniele</creatorcontrib><creatorcontrib>Farcomeni, Alessio</creatorcontrib><creatorcontrib>Basili, Stefania</creatorcontrib><creatorcontrib>Davì, Giovanni</creatorcontrib><creatorcontrib>Ferro, Domenico</creatorcontrib><creatorcontrib>Hiatt, William R</creatorcontrib><creatorcontrib>Licata, Giuseppe</creatorcontrib><creatorcontrib>Lip, Gregory Y.H</creatorcontrib><creatorcontrib>Loffredo, Lorenzo</creatorcontrib><creatorcontrib>Mannucci, Pier Mannuccio</creatorcontrib><creatorcontrib>Vestri, Annarita</creatorcontrib><creatorcontrib>Violi, Francesco</creatorcontrib><creatorcontrib>in collaboration with the ARA PACIS study group</creatorcontrib><creatorcontrib>ARA PACIS study group</creatorcontrib><title>Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation</title><title>International journal of cardiology</title><addtitle>Int J Cardiol</addtitle><description>Abstract Background Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties. Our aim was to assess whether vitamin E is associated with cardiovascular events in patients with non-valvular atrial fibrillation. Methods Serum levels of cholesterol-adjusted vitamin E were measured in 1012 patients with non-valvular atrial fibrillation. Patients were followed for a mean time of 27.0 months, and cardiovascular events, such as cardiovascular death and fatal and nonfatal stroke or myocardial infarction, were recorded. Results During the follow-up period, cardiovascular events occurred in 109 (11%) patients (18 fatal and 14 nonfatal myocardial infarction; 13 fatal and 19 nonfatal ischemic strokes; 45 cardiovascular deaths). Lower vitamin E serum levels were found in patients who experienced cardiovascular events compared to those who did not (3.8 ± 1.2 vs. 4.4 ± 1.8 μmol/mmol cholesterol; p < 0.001). Using a Cox proportional hazard model, age, diabetes, history of stroke and myocardial infarction and vitamin E serum levels (HR 0.77; 95% CI: 0.67–0.89; p = 0.001) independently predicted cardiovascular events. Patients with vitamin E < 4.2 μmol/mmol cholesterol (median values) had an increased risk of cardiovascular events (HR 1.87; 95% CI: 1.25–2.80: p = 0.002). Conclusions Low vitamin E serum levels are associated with an increased risk of cardiovascular events in patients with non-valvular atrial fibrillation.</description><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Atrial fibrillation</subject><subject>Atrial Fibrillation - blood</subject><subject>Atrial Fibrillation - diagnosis</subject><subject>Biological and medical sciences</subject><subject>Biomarkers - blood</subject><subject>Cardiac dysrhythmias</subject><subject>Cardiology. Vascular system</subject><subject>Cardiovascular</subject><subject>Cardiovascular events</subject><subject>Cholesterol - blood</subject><subject>Disorders of blood lipids. Hyperlipoproteinemia</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Heart</subject><subject>Humans</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Metabolic diseases</subject><subject>Middle Aged</subject><subject>Prospective Studies</subject><subject>Vitamin E</subject><subject>Vitamin E - blood</subject><issn>0167-5273</issn><issn>1874-1754</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFks1u1DAUhS0EokPhDRDyBolNgv9mHG-Q0Kj8SJVY0K4tx75RHZx4sJOgPgGvXWdmAIlNV76L79x7fc5F6DUlNSV0976vfW9NcjUjlNdE1FSwJ2hDGykqKrfiKdoUTFZbJvkFepFzTwgRSjXP0QXjuy1tmNyg3_u7GCBPkGKojOvnUjq8-MkMfsRXOEOaBxxggZCxSYBNztF6s1K__HSH1xV8XEy2czAJF3CcMi7ag5n8sT5iYxyrxYTlCJkpeRNw59vkQyhcHF-iZ50JGV6d30t0--nqZv-luv72-ev-43VlhZBTte2EckJZQTtnqOGuAWGBkZ2ynNtd05GWt7JtqSPMNQKYUZQyxoohErrixCV6d-p7SPHnXD6uB58tlC1GiHPWVAiulBRNU1BxQm2KOSfo9CH5waR7TYleI9C9PkWg1wg0EUXNiuzNecLcDuD-iv54XoC3Z6CYZkKXzGh9_sdJRZSgpHAfTlyxHhYPSWdbHLXgfAI7aRf9Y5v838AGP_oy8wfcQ-7jnMbitaY6M0309_Vc1muhnBDZKMEfALDBvmI</recordid><startdate>20131009</startdate><enddate>20131009</enddate><creator>Cangemi, Roberto</creator><creator>Pignatelli, Pasquale</creator><creator>Carnevale, Roberto</creator><creator>Corazza, Gino Roberto</creator><creator>Pastori, Daniele</creator><creator>Farcomeni, Alessio</creator><creator>Basili, Stefania</creator><creator>Davì, Giovanni</creator><creator>Ferro, Domenico</creator><creator>Hiatt, William R</creator><creator>Licata, Giuseppe</creator><creator>Lip, Gregory Y.H</creator><creator>Loffredo, Lorenzo</creator><creator>Mannucci, Pier Mannuccio</creator><creator>Vestri, Annarita</creator><creator>Violi, Francesco</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131009</creationdate><title>Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation</title><author>Cangemi, Roberto ; Pignatelli, Pasquale ; Carnevale, Roberto ; Corazza, Gino Roberto ; Pastori, Daniele ; Farcomeni, Alessio ; Basili, Stefania ; Davì, Giovanni ; Ferro, Domenico ; Hiatt, William R ; Licata, Giuseppe ; Lip, Gregory Y.H ; Loffredo, Lorenzo ; Mannucci, Pier Mannuccio ; Vestri, Annarita ; Violi, Francesco</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c447t-5f49d49c41fda1a3d8e4ce2069c33c68f0b3b7bb1d02d84e2a9112221757ef273</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Atrial fibrillation</topic><topic>Atrial Fibrillation - blood</topic><topic>Atrial Fibrillation - diagnosis</topic><topic>Biological and medical sciences</topic><topic>Biomarkers - blood</topic><topic>Cardiac dysrhythmias</topic><topic>Cardiology. Vascular system</topic><topic>Cardiovascular</topic><topic>Cardiovascular events</topic><topic>Cholesterol - blood</topic><topic>Disorders of blood lipids. Hyperlipoproteinemia</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Heart</topic><topic>Humans</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Metabolic diseases</topic><topic>Middle Aged</topic><topic>Prospective Studies</topic><topic>Vitamin E</topic><topic>Vitamin E - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cangemi, Roberto</creatorcontrib><creatorcontrib>Pignatelli, Pasquale</creatorcontrib><creatorcontrib>Carnevale, Roberto</creatorcontrib><creatorcontrib>Corazza, Gino Roberto</creatorcontrib><creatorcontrib>Pastori, Daniele</creatorcontrib><creatorcontrib>Farcomeni, Alessio</creatorcontrib><creatorcontrib>Basili, Stefania</creatorcontrib><creatorcontrib>Davì, Giovanni</creatorcontrib><creatorcontrib>Ferro, Domenico</creatorcontrib><creatorcontrib>Hiatt, William R</creatorcontrib><creatorcontrib>Licata, Giuseppe</creatorcontrib><creatorcontrib>Lip, Gregory Y.H</creatorcontrib><creatorcontrib>Loffredo, Lorenzo</creatorcontrib><creatorcontrib>Mannucci, Pier Mannuccio</creatorcontrib><creatorcontrib>Vestri, Annarita</creatorcontrib><creatorcontrib>Violi, Francesco</creatorcontrib><creatorcontrib>in collaboration with the ARA PACIS study group</creatorcontrib><creatorcontrib>ARA PACIS study group</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of cardiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Cangemi, Roberto</au><au>Pignatelli, Pasquale</au><au>Carnevale, Roberto</au><au>Corazza, Gino Roberto</au><au>Pastori, Daniele</au><au>Farcomeni, Alessio</au><au>Basili, Stefania</au><au>Davì, Giovanni</au><au>Ferro, Domenico</au><au>Hiatt, William R</au><au>Licata, Giuseppe</au><au>Lip, Gregory Y.H</au><au>Loffredo, Lorenzo</au><au>Mannucci, Pier Mannuccio</au><au>Vestri, Annarita</au><au>Violi, Francesco</au><aucorp>in collaboration with the ARA PACIS study group</aucorp><aucorp>ARA PACIS study group</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation</atitle><jtitle>International journal of cardiology</jtitle><addtitle>Int J Cardiol</addtitle><date>2013-10-09</date><risdate>2013</risdate><volume>168</volume><issue>4</issue><spage>3241</spage><epage>3247</epage><pages>3241-3247</pages><issn>0167-5273</issn><eissn>1874-1754</eissn><coden>IJCDD5</coden><abstract>Abstract Background Non-valvular atrial fibrillation is associated with an increase in thromboembolism, i.e. stroke, and atherosclerotic events, i.e. myocardial infarction. Vitamin E possesses anti-coagulant as well as anti-atherosclerotic properties. Our aim was to assess whether vitamin E is associated with cardiovascular events in patients with non-valvular atrial fibrillation. Methods Serum levels of cholesterol-adjusted vitamin E were measured in 1012 patients with non-valvular atrial fibrillation. Patients were followed for a mean time of 27.0 months, and cardiovascular events, such as cardiovascular death and fatal and nonfatal stroke or myocardial infarction, were recorded. Results During the follow-up period, cardiovascular events occurred in 109 (11%) patients (18 fatal and 14 nonfatal myocardial infarction; 13 fatal and 19 nonfatal ischemic strokes; 45 cardiovascular deaths). Lower vitamin E serum levels were found in patients who experienced cardiovascular events compared to those who did not (3.8 ± 1.2 vs. 4.4 ± 1.8 μmol/mmol cholesterol; p < 0.001). Using a Cox proportional hazard model, age, diabetes, history of stroke and myocardial infarction and vitamin E serum levels (HR 0.77; 95% CI: 0.67–0.89; p = 0.001) independently predicted cardiovascular events. Patients with vitamin E < 4.2 μmol/mmol cholesterol (median values) had an increased risk of cardiovascular events (HR 1.87; 95% CI: 1.25–2.80: p = 0.002). Conclusions Low vitamin E serum levels are associated with an increased risk of cardiovascular events in patients with non-valvular atrial fibrillation.</abstract><cop>Shannon</cop><pub>Elsevier Ireland Ltd</pub><pmid>23651827</pmid><doi>10.1016/j.ijcard.2013.04.142</doi><tpages>7</tpages></addata></record> |
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| subjects | Aged Aged, 80 and over Atrial fibrillation Atrial Fibrillation - blood Atrial Fibrillation - diagnosis Biological and medical sciences Biomarkers - blood Cardiac dysrhythmias Cardiology. Vascular system Cardiovascular Cardiovascular events Cholesterol - blood Disorders of blood lipids. Hyperlipoproteinemia Female Follow-Up Studies Heart Humans Male Medical sciences Metabolic diseases Middle Aged Prospective Studies Vitamin E Vitamin E - blood |
| title | Cholesterol-adjusted vitamin E serum levels are associated with cardiovascular events in patients with non-valvular atrial fibrillation |
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