Therapeutic option for managing lung injury induced by infrarenal aortic cross-clamping

Abstract Background Operations on the infrarenal aorta can cause ischemic-reperfusion (IR) injury in local tissues, which could result in remote organ (e.g., lung) damage. Treatment of such injuries remains an unresolved problem. Objectives Our aim was to reduce remote lung damage after lower limb I...

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Veröffentlicht in:	The Journal of surgical research 2013-11, Vol.185 (1), p.469-476
Hauptverfasser:	Garbaisz, David, MD, Turoczi, Zsolt, MD, Fulop, Andras, MD, Rosero, Oliver, MD, Aranyi, Peter, MD, Onody, Peter, MD, Lotz, Gabor, MD, PhD, Rakonczay, Zoltan, MD, PhD, Balla, Zsolt, Harsanyi, Laszlo, MD, PhD, Szijarto, Attila, MD, PhD
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - etiology Acute Lung Injury - metabolism Acute Lung Injury - therapy Animals Aorta, Abdominal - surgery ARDS Disease Models, Animal Free Radicals - metabolism Hindlimb - blood supply Hindlimb - surgery Interleukin-6 - metabolism Ischemia-reperfusion Ischemic Postconditioning - methods Lower limb Lung damage Male Postconditioning Postoperative Complications - etiology Postoperative Complications - metabolism Postoperative Complications - therapy Rats Rats, Wistar Reperfusion Injury - complications Reperfusion Injury - metabolism Surgery Surgical Instruments Systemic inflammatory response syndrome Tumor Necrosis Factor-alpha - metabolism Vascular Surgical Procedures - adverse effects
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