Induction of apoptosis in T lymphoma cells by long-term treatment with thyroxine involves PKCζ nitration by nitric oxide synthase

Thyroid hormones are important regulators of cell physiology, inducing cell proliferation, differentiation or apoptosis, depending on the cell type. Thyroid hormones induce proliferation in short-term T lymphocyte cultures. In this study, we assessed the effect of long-term thyroxine (T4) treatment...

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Veröffentlicht in:	Apoptosis (London) 2013-11, Vol.18 (11), p.1376-1390
Hauptverfasser:	Barreiro Arcos, M. L., Sterle, H. A., Vercelli, C., Valli, E., Cayrol, M. F., Klecha, A. J., Paulazo, M. A., Diaz Flaqué, M. C., Franchi, A. M., Cremaschi, G. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Annexin A5 Apoptosis - drug effects Biochemistry Biomedical and Life Sciences Biomedicine Cancer Research Cell Biology Cell Line, Tumor Cell Proliferation Coloring Agents DNA Fragmentation - drug effects Gene Expression Regulation Glutathione - metabolism Lymphoma, T-Cell - genetics Lymphoma, T-Cell - metabolism Lymphoma, T-Cell - pathology Membrane Potential, Mitochondrial - drug effects Mice Mitochondria - drug effects Mitochondria - metabolism Nitrates - metabolism Nitric Oxide Synthase Type II - genetics Nitric Oxide Synthase Type II - metabolism Oncology Original Paper Propidium Proteasome Endopeptidase Complex - drug effects Proteasome Endopeptidase Complex - metabolism Protein Kinase C - genetics Protein Kinase C - metabolism Proteolysis - drug effects Reactive Oxygen Species - metabolism Signal Transduction Thyroxine - pharmacology Time Factors Virology
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