In vivo evaluation and comparison of developmental toxicity and teratogenicity of perfluoroalkyl compounds using Xenopus embryos

•PFCs are proved to be developmental toxicants.•Embryos exposed to PFCs develop various abnormalities.•Heart- and liver-specific RNAs are significantly down-regulated by exposure to PFCs.•Heart defects and hepatomegaly are induced by PFCs. Perfluoroalkyl compounds (PFCs) are environmental toxicants...

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Veröffentlicht in:	Chemosphere (Oxford) 2013-10, Vol.93 (6), p.1153-1160
Hauptverfasser:	Kim, Miran, Son, Jungeun, Park, Mi Seon, Ji, Yurim, Chae, Soomin, Jun, Changduk, Bae, Jong-Sup, Kwon, Taek Kyu, Choo, Yun-Sik, Yoon, Hosung, Yoon, Duhak, Ryoo, Jaewoong, Kim, Sang-Hyun, Park, Mae-Ja, Lee, Hyun-Shik
Format:	Artikel
Sprache:	eng
Schlagworte:	animal models Animal, plant and microbial ecology Animals Applied ecology Biological and medical sciences biomarkers blood Caprylates - toxicity carbon Comparative toxicology Decanoic Acids - toxicity Developmental toxicity ecosystems Ecotoxicology, biological effects of pollution Effects of pollution and side effects of pesticides on vertebrates Embryo, Nonmammalian - drug effects embryogenesis Embryology: invertebrates and vertebrates. Teratology Environmental Pollutants - toxicity Fluorocarbons - toxicity Fundamental and applied biological sciences. Psychology heart humans in situ hybridization liver Perfluoroalkyl compounds perfluorocarbons quantitative polymerase chain reaction Real-Time Polymerase Chain Reaction Reptilia. Amphibia Teratogenecity teratogenicity teratogens Teratogens - toxicity Teratology. Teratogens Xenopus Xenopus laevis - embryology Xenopus laevis - physiology
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