Central nervous system myelin deficit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation
Our results show that 2,4-dichlorophenoxyacetic acid (2,4-D) exposure through mother's milk during the period of rapid myelination (from the 15th to the 25th postnatal days) results in a myelin deficit in the pup's brain and demonstrates the vulnerability of the developing central nervous...
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| Veröffentlicht in: | Neurotoxicology and teratology 1996-11, Vol.18 (6), p.691-696 |
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| container_title | Neurotoxicology and teratology |
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| creator | Duffard, Ricardo Garcia, Graciela Rosso, Silvana Bortolozzi, Analia Madariaga, Maria Di Paolo, Oscar De Duffard, Ana Maria Evangelista |
| description | Our results show that 2,4-dichlorophenoxyacetic acid (2,4-D) exposure through mother's milk during the period of rapid myelination (from the 15th to the 25th postnatal days) results in a myelin deficit in the pup's brain and demonstrates the vulnerability of the developing central nervous system (CNS) to 2,4-D. After 100 mg/kg 2,4-D administration to dams, brains of male and female rats show a significant diminution of myelin markers such as monohexosylceramide as well as phospholipids and free fatty acids (FFA) and an increase of cholesteryl esters. Histological studies revealed myelin deficit in some brain regions after 2,4-D treatment. These data indicate that 2,4-D, through the mother's milk, alters the myelination process during a specific postnatal period. |
| doi_str_mv | 10.1016/S0892-0362(96)00087-6 |
| format | Article |
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After 100 mg/kg 2,4-D administration to dams, brains of male and female rats show a significant diminution of myelin markers such as monohexosylceramide as well as phospholipids and free fatty acids (FFA) and an increase of cholesteryl esters. Histological studies revealed myelin deficit in some brain regions after 2,4-D treatment. 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After 100 mg/kg 2,4-D administration to dams, brains of male and female rats show a significant diminution of myelin markers such as monohexosylceramide as well as phospholipids and free fatty acids (FFA) and an increase of cholesteryl esters. Histological studies revealed myelin deficit in some brain regions after 2,4-D treatment. These data indicate that 2,4-D, through the mother's milk, alters the myelination process during a specific postnatal period.</description><subject>2,4-Dichlorophenoxyacetic acid</subject><subject>2,4-Dichlorophenoxyacetic Acid - toxicity</subject><subject>Analysis of Variance</subject><subject>Animals</subject><subject>Animals, Suckling</subject><subject>Biological and medical sciences</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Brain - pathology</subject><subject>Cholesterol - metabolism</subject><subject>Cholesterol Esters - metabolism</subject><subject>Developmental Toxicity</subject><subject>Fatty Acids, Nonesterified - metabolism</subject><subject>Female</subject><subject>Herbicides - toxicity</subject><subject>Lactation</subject><subject>Lipid Metabolism</subject><subject>Male</subject><subject>Maternal Exposure</subject><subject>Medical sciences</subject><subject>Myelin</subject><subject>Myelin Sheath - drug effects</subject><subject>Myelin Sheath - pathology</subject><subject>Neurotoxins</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Phenoxyherbicides</subject><subject>Phospholipids - metabolism</subject><subject>Rats</subject><subject>Toxicology</subject><issn>0892-0362</issn><issn>1872-9738</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1996</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkEuLFDEQgIMo6zj6ExZyEFGwNY_udHISGXzBggf1HGqqq51IT2dM0svOvze7M8zVUxXUV6-PsWsp3kkhzfsfwjrVCG3Ua2feCCFs35hHbCVtrxrXa_uYrS7IU_Ys5z8V6o0UV-zKurZ3rVmxaUNzSTDxmdJtXDLPx1xoz_dHmsLMBxoDhsJrmqBkTneHmGngJXL1tm2GgLsppnjY0RzvjoBUAnLAUIldisvvXVwKnwALlBDn5-zJCFOmF-e4Zr8-f_q5-drcfP_ybfPxpsFWidKQRIvOgu6kAxKgCQxaYXoSRrtBO2oHhbZTuBUDbp0mpdq-AzdqABRar9mr09xDin8XysXvQ0aaJpip_uhl22rXV0dr1p1ATDHnRKM_pLCHdPRS-HvL_sGyv1fonfEPlr2pfdfnBct2T8Ol66y11l-e65ARpjHBjCFfMNXVg62s2IcTRlXGbaDkMwaakYaQCIsfYvjPIf8ArAebMw</recordid><startdate>19961101</startdate><enddate>19961101</enddate><creator>Duffard, Ricardo</creator><creator>Garcia, Graciela</creator><creator>Rosso, Silvana</creator><creator>Bortolozzi, Analia</creator><creator>Madariaga, Maria</creator><creator>Di Paolo, Oscar</creator><creator>De Duffard, Ana Maria Evangelista</creator><general>Elsevier Inc</general><general>Elsevier Science</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>19961101</creationdate><title>Central nervous system myelin deficit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation</title><author>Duffard, Ricardo ; Garcia, Graciela ; Rosso, Silvana ; Bortolozzi, Analia ; Madariaga, Maria ; Di Paolo, Oscar ; De Duffard, Ana Maria Evangelista</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-e1c8c98a3519ae0a3ea6c8067e0639d39e4d2c852cb0dcb93e22475a9f3aac033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1996</creationdate><topic>2,4-Dichlorophenoxyacetic acid</topic><topic>2,4-Dichlorophenoxyacetic Acid - toxicity</topic><topic>Analysis of Variance</topic><topic>Animals</topic><topic>Animals, Suckling</topic><topic>Biological and medical sciences</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Brain - pathology</topic><topic>Cholesterol - metabolism</topic><topic>Cholesterol Esters - metabolism</topic><topic>Developmental Toxicity</topic><topic>Fatty Acids, Nonesterified - metabolism</topic><topic>Female</topic><topic>Herbicides - toxicity</topic><topic>Lactation</topic><topic>Lipid Metabolism</topic><topic>Male</topic><topic>Maternal Exposure</topic><topic>Medical sciences</topic><topic>Myelin</topic><topic>Myelin Sheath - drug effects</topic><topic>Myelin Sheath - pathology</topic><topic>Neurotoxins</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Phenoxyherbicides</topic><topic>Phospholipids - metabolism</topic><topic>Rats</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Duffard, Ricardo</creatorcontrib><creatorcontrib>Garcia, Graciela</creatorcontrib><creatorcontrib>Rosso, Silvana</creatorcontrib><creatorcontrib>Bortolozzi, Analia</creatorcontrib><creatorcontrib>Madariaga, Maria</creatorcontrib><creatorcontrib>Di Paolo, Oscar</creatorcontrib><creatorcontrib>De Duffard, Ana Maria Evangelista</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Neurotoxicology and teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Duffard, Ricardo</au><au>Garcia, Graciela</au><au>Rosso, Silvana</au><au>Bortolozzi, Analia</au><au>Madariaga, Maria</au><au>Di Paolo, Oscar</au><au>De Duffard, Ana Maria Evangelista</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Central nervous system myelin deficit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation</atitle><jtitle>Neurotoxicology and teratology</jtitle><addtitle>Neurotoxicol Teratol</addtitle><date>1996-11-01</date><risdate>1996</risdate><volume>18</volume><issue>6</issue><spage>691</spage><epage>696</epage><pages>691-696</pages><issn>0892-0362</issn><eissn>1872-9738</eissn><coden>NETEEC</coden><abstract>Our results show that 2,4-dichlorophenoxyacetic acid (2,4-D) exposure through mother's milk during the period of rapid myelination (from the 15th to the 25th postnatal days) results in a myelin deficit in the pup's brain and demonstrates the vulnerability of the developing central nervous system (CNS) to 2,4-D. After 100 mg/kg 2,4-D administration to dams, brains of male and female rats show a significant diminution of myelin markers such as monohexosylceramide as well as phospholipids and free fatty acids (FFA) and an increase of cholesteryl esters. Histological studies revealed myelin deficit in some brain regions after 2,4-D treatment. These data indicate that 2,4-D, through the mother's milk, alters the myelination process during a specific postnatal period.</abstract><cop>New York, NY</cop><pub>Elsevier Inc</pub><pmid>8947946</pmid><doi>10.1016/S0892-0362(96)00087-6</doi><tpages>6</tpages></addata></record> |
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| subjects | 2,4-Dichlorophenoxyacetic acid 2,4-Dichlorophenoxyacetic Acid - toxicity Analysis of Variance Animals Animals, Suckling Biological and medical sciences Brain - drug effects Brain - metabolism Brain - pathology Cholesterol - metabolism Cholesterol Esters - metabolism Developmental Toxicity Fatty Acids, Nonesterified - metabolism Female Herbicides - toxicity Lactation Lipid Metabolism Male Maternal Exposure Medical sciences Myelin Myelin Sheath - drug effects Myelin Sheath - pathology Neurotoxins Pesticides, fertilizers and other agrochemicals toxicology Phenoxyherbicides Phospholipids - metabolism Rats Toxicology |
| title | Central nervous system myelin deficit in rats exposed to 2,4-dichlorophenoxyacetic acid throughout lactation |
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