IGF1 modifications after bariatric surgery in morbidly obese patients: potential implications of nutritional status according to specific surgical technique

ObjectivesIGF1 is decreased in morbidly obese (MO) patients and its changes after bariatric surgery weight loss (WL) are not well known. The aim of this study was to analyse IGF1 modifications in MO patients after WL and its relationship to ghrelin and to different types of surgeries.DesignRetrospec...

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Veröffentlicht in:	European journal of endocrinology 2013-11, Vol.169 (5), p.695-703
Hauptverfasser:	Pellitero, Silvia, Granada, María Luisa, Martínez, Eva, Balibrea, Jose María, Guanyabens, Elena, Serra, Assumpta, Moreno, Pau, Navarro, Maruja, Romero, Ramon, Alastrué, Antonio, Puig-Domingo, Manel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Bariatric Surgery - methods Biological and medical sciences Body Mass Index Clinical Study Endocrinopathies Female Fundamental and applied biological sciences. Psychology Ghrelin - blood Homeostasis Humans Hypertension - blood Hypertension - complications Insulin - blood Insulin Resistance Insulin-Like Growth Factor Binding Protein 3 - blood Insulin-Like Growth Factor I - metabolism Lipids - blood Male Medical sciences Middle Aged Nutritional Status Obesity, Morbid - blood Obesity, Morbid - surgery Odds Ratio Prospective Studies Regression Analysis Serum Albumin - metabolism Stomach, duodenum, intestine, rectum, anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Vertebrates: endocrinology
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Zusammenfassung:	ObjectivesIGF1 is decreased in morbidly obese (MO) patients and its changes after bariatric surgery weight loss (WL) are not well known. The aim of this study was to analyse IGF1 modifications in MO patients after WL and its relationship to ghrelin and to different types of surgeries.DesignRetrospective follow-up study at the University Medical Center.MethodsOne hundred and nine MO patients (age 44.1±9.3, BMI 51.74±8.75 kg/m2) were evaluated at baseline and 1 year after surgery: 28 sleeve gastrectomy (SG), 31 distal modified (m), and 50 ringed (r) Roux-en-Y gastric bypass (RYGBP) surgery. Changes in IGF1, IGFBP3, ratio IGF1:IGFBP3, and ghrelin were evaluated 1 year after surgery.ResultsBaseline prevalence of low IGF1 (defined by s.d. IGF1
ISSN:	0804-4643 1479-683X
DOI:	10.1530/EJE-13-0209