Modulation of the foreign body response to implanted sensor models through device-based delivery of the tyrosine kinase inhibitor, masitinib

Abstract The host foreign body response (FBR) adversely effects the performance of numerous implanted biomaterials especially biosensors, including clinically popular glucose-monitoring sensors. Reactive formation of a fibrous capsule around implanted sensors hinders the transport of essential analy...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Biomaterials 2013-12, Vol.34 (38), p.9737-9746
Hauptverfasser:	Avula, Mahender Nath, Rao, Archana Nagaraja, McGill, Lawrence D, Grainger, David William, Solzbacher, Florian
Format:	Artikel
Sprache:	eng
Schlagworte:	Advanced Basic Science Animals Biocompatible Materials - chemistry Biomedical implants Biosensing Techniques Continuous glucose monitoring sensors Dentistry Foreign body response Foreign-Body Reaction - immunology Foreign-Body Reaction - prevention & control Lactic Acid - chemistry Local drug delivery Male Mast cells Mice Mice, Inbred C57BL Polyethylene Glycols - chemistry Polyglycolic Acid - chemistry Prostheses and Implants Protein Kinase Inhibitors - chemistry Protein Kinase Inhibitors - pharmacology Thiazoles - chemistry Thiazoles - pharmacology Tyrosine kinase inhibitor
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!