Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin
Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, guided by recent advances in clinically relevant optical imaging technologies, we explore the use of fluorescently labelled vancomycin (vanco-800CW) to specifically target and detect infections...
Gespeichert in:
| Veröffentlicht in: | Nature communications 2013-10, Vol.4 (1), p.2584-2584, Article 2584 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext bestellen |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 2584 |
|---|---|
| container_issue | 1 |
| container_start_page | 2584 |
| container_title | Nature communications |
| container_volume | 4 |
| creator | van Oosten, Marleen Schäfer, Tina Gazendam, Joost A. C. Ohlsen, Knut Tsompanidou, Eleni de Goffau, Marcus C. Harmsen, Hermie J. M. Crane, Lucia M. A. Lim, Ed Francis, Kevin P. Cheung, Lael Olive, Michael Ntziachristos, Vasilis van Dijl, Jan Maarten van Dam, Gooitzen M. |
| description | Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, guided by recent advances in clinically relevant optical imaging technologies, we explore the use of fluorescently labelled vancomycin (vanco-800CW) to specifically target and detect infections caused by Gram-positive bacteria. The application potential of vanco-800CW for real-time
in vivo
imaging of bacterial infections is assessed in a mouse myositis model and a human
post-mortem
implant model. We show that vanco-800CW can specifically detect Gram-positive bacterial infections in our mouse myositis model, discriminate bacterial infections from sterile inflammation
in vivo
and detect biomaterial-associated infections in the lower leg of a human cadaver. We conclude that vanco-800CW has a high potential for enhanced non-invasive diagnosis of infections with Gram-positive bacteria and is a promising candidate for early-phase clinical trials.
Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, the authors demonstrate that real-time
in vivo
detection and imaging of these bacterial infections can be successfully performed with fluorescently labelled vancomycin. |
| doi_str_mv | 10.1038/ncomms3584 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_C6C</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443428712</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3098893941</sourcerecordid><originalsourceid>FETCH-LOGICAL-c387t-ff5899d24a196b0efbd93d5d1dd8a615bc2892f848d8431b55032e908fb6cdde3</originalsourceid><addsrcrecordid>eNplkVtLBSEUhSWKiuqlHxADvUQxNV7mHH2MQzcIgqjnwdHtwXC0dGbgvPTbczjdKEHU5beXCzdCh7g6xxXlF16Frku05mwD7ZKK4RLPCd38td9BBym9VHlQgTlj22iHMExEnrvo_RGkK3vbQWF9MdoxFLaTS-uXRTBZGmWyI5SF9LpobehkD9HmCplSUDafsizVWsy4AdXb4FMxpMnCuCFESAp871aFky04lytGOaVeKev30ZaRLsHB57qHnq-vnha35f3Dzd3i8r5UlM_70piaC6EJk1jM2gpMqwXVtcZacznDdasIF8RwxjVnFLd1XVECouKmnSmtge6hk7XvawxvA6S-6WyO5Zz0EIbUYMYoI3yOSUaP_6AvYYg-p5sozAUm84k6XVMqhpQimOY15o-LqwZXzdSY5qcxGT76tBzaDvQ3-tWGDJytgZSv_BLirzf_230Ay0aavQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1441891272</pqid></control><display><type>article</type><title>Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin</title><source>Springer Open Access</source><creator>van Oosten, Marleen ; Schäfer, Tina ; Gazendam, Joost A. C. ; Ohlsen, Knut ; Tsompanidou, Eleni ; de Goffau, Marcus C. ; Harmsen, Hermie J. M. ; Crane, Lucia M. A. ; Lim, Ed ; Francis, Kevin P. ; Cheung, Lael ; Olive, Michael ; Ntziachristos, Vasilis ; van Dijl, Jan Maarten ; van Dam, Gooitzen M.</creator><creatorcontrib>van Oosten, Marleen ; Schäfer, Tina ; Gazendam, Joost A. C. ; Ohlsen, Knut ; Tsompanidou, Eleni ; de Goffau, Marcus C. ; Harmsen, Hermie J. M. ; Crane, Lucia M. A. ; Lim, Ed ; Francis, Kevin P. ; Cheung, Lael ; Olive, Michael ; Ntziachristos, Vasilis ; van Dijl, Jan Maarten ; van Dam, Gooitzen M.</creatorcontrib><description>Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, guided by recent advances in clinically relevant optical imaging technologies, we explore the use of fluorescently labelled vancomycin (vanco-800CW) to specifically target and detect infections caused by Gram-positive bacteria. The application potential of vanco-800CW for real-time
in vivo
imaging of bacterial infections is assessed in a mouse myositis model and a human
post-mortem
implant model. We show that vanco-800CW can specifically detect Gram-positive bacterial infections in our mouse myositis model, discriminate bacterial infections from sterile inflammation
in vivo
and detect biomaterial-associated infections in the lower leg of a human cadaver. We conclude that vanco-800CW has a high potential for enhanced non-invasive diagnosis of infections with Gram-positive bacteria and is a promising candidate for early-phase clinical trials.
Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, the authors demonstrate that real-time
in vivo
detection and imaging of these bacterial infections can be successfully performed with fluorescently labelled vancomycin.</description><identifier>ISSN: 2041-1723</identifier><identifier>EISSN: 2041-1723</identifier><identifier>DOI: 10.1038/ncomms3584</identifier><identifier>PMID: 24129412</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/1647/245 ; 692/308 ; 692/699/255/1318 ; 692/700/139 ; Animals ; Anti-Bacterial Agents - chemistry ; Benzenesulfonates - chemistry ; Biocompatible Materials - adverse effects ; Cadaver ; Diagnostic Imaging - methods ; Disease Models, Animal ; Fluorescent Dyes - chemistry ; Gram-Positive Bacteria - growth & development ; Gram-Positive Bacterial Infections - diagnosis ; Gram-Positive Bacterial Infections - microbiology ; Humanities and Social Sciences ; Humans ; Image Interpretation, Computer-Assisted ; Indoles - chemistry ; Mice ; multidisciplinary ; Myositis - diagnosis ; Myositis - microbiology ; Science ; Science (multidisciplinary) ; Time Factors ; Vancomycin - chemistry</subject><ispartof>Nature communications, 2013-10, Vol.4 (1), p.2584-2584, Article 2584</ispartof><rights>Springer Nature Limited 2013</rights><rights>Copyright Nature Publishing Group Oct 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c387t-ff5899d24a196b0efbd93d5d1dd8a615bc2892f848d8431b55032e908fb6cdde3</citedby><cites>FETCH-LOGICAL-c387t-ff5899d24a196b0efbd93d5d1dd8a615bc2892f848d8431b55032e908fb6cdde3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/ncomms3584$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://doi.org/10.1038/ncomms3584$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>315,782,786,27933,27934,41129,42198,51585</link.rule.ids><linktorsrc>$$Uhttps://doi.org/10.1038/ncomms3584$$EView_record_in_Springer_Nature$$FView_record_in_$$GSpringer_Nature</linktorsrc><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24129412$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>van Oosten, Marleen</creatorcontrib><creatorcontrib>Schäfer, Tina</creatorcontrib><creatorcontrib>Gazendam, Joost A. C.</creatorcontrib><creatorcontrib>Ohlsen, Knut</creatorcontrib><creatorcontrib>Tsompanidou, Eleni</creatorcontrib><creatorcontrib>de Goffau, Marcus C.</creatorcontrib><creatorcontrib>Harmsen, Hermie J. M.</creatorcontrib><creatorcontrib>Crane, Lucia M. A.</creatorcontrib><creatorcontrib>Lim, Ed</creatorcontrib><creatorcontrib>Francis, Kevin P.</creatorcontrib><creatorcontrib>Cheung, Lael</creatorcontrib><creatorcontrib>Olive, Michael</creatorcontrib><creatorcontrib>Ntziachristos, Vasilis</creatorcontrib><creatorcontrib>van Dijl, Jan Maarten</creatorcontrib><creatorcontrib>van Dam, Gooitzen M.</creatorcontrib><title>Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin</title><title>Nature communications</title><addtitle>Nat Commun</addtitle><addtitle>Nat Commun</addtitle><description>Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, guided by recent advances in clinically relevant optical imaging technologies, we explore the use of fluorescently labelled vancomycin (vanco-800CW) to specifically target and detect infections caused by Gram-positive bacteria. The application potential of vanco-800CW for real-time
in vivo
imaging of bacterial infections is assessed in a mouse myositis model and a human
post-mortem
implant model. We show that vanco-800CW can specifically detect Gram-positive bacterial infections in our mouse myositis model, discriminate bacterial infections from sterile inflammation
in vivo
and detect biomaterial-associated infections in the lower leg of a human cadaver. We conclude that vanco-800CW has a high potential for enhanced non-invasive diagnosis of infections with Gram-positive bacteria and is a promising candidate for early-phase clinical trials.
Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, the authors demonstrate that real-time
in vivo
detection and imaging of these bacterial infections can be successfully performed with fluorescently labelled vancomycin.</description><subject>631/1647/245</subject><subject>692/308</subject><subject>692/699/255/1318</subject><subject>692/700/139</subject><subject>Animals</subject><subject>Anti-Bacterial Agents - chemistry</subject><subject>Benzenesulfonates - chemistry</subject><subject>Biocompatible Materials - adverse effects</subject><subject>Cadaver</subject><subject>Diagnostic Imaging - methods</subject><subject>Disease Models, Animal</subject><subject>Fluorescent Dyes - chemistry</subject><subject>Gram-Positive Bacteria - growth & development</subject><subject>Gram-Positive Bacterial Infections - diagnosis</subject><subject>Gram-Positive Bacterial Infections - microbiology</subject><subject>Humanities and Social Sciences</subject><subject>Humans</subject><subject>Image Interpretation, Computer-Assisted</subject><subject>Indoles - chemistry</subject><subject>Mice</subject><subject>multidisciplinary</subject><subject>Myositis - diagnosis</subject><subject>Myositis - microbiology</subject><subject>Science</subject><subject>Science (multidisciplinary)</subject><subject>Time Factors</subject><subject>Vancomycin - chemistry</subject><issn>2041-1723</issn><issn>2041-1723</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNplkVtLBSEUhSWKiuqlHxADvUQxNV7mHH2MQzcIgqjnwdHtwXC0dGbgvPTbczjdKEHU5beXCzdCh7g6xxXlF16Frku05mwD7ZKK4RLPCd38td9BBym9VHlQgTlj22iHMExEnrvo_RGkK3vbQWF9MdoxFLaTS-uXRTBZGmWyI5SF9LpobehkD9HmCplSUDafsizVWsy4AdXb4FMxpMnCuCFESAp871aFky04lytGOaVeKev30ZaRLsHB57qHnq-vnha35f3Dzd3i8r5UlM_70piaC6EJk1jM2gpMqwXVtcZacznDdasIF8RwxjVnFLd1XVECouKmnSmtge6hk7XvawxvA6S-6WyO5Zz0EIbUYMYoI3yOSUaP_6AvYYg-p5sozAUm84k6XVMqhpQimOY15o-LqwZXzdSY5qcxGT76tBzaDvQ3-tWGDJytgZSv_BLirzf_230Ay0aavQ</recordid><startdate>20131015</startdate><enddate>20131015</enddate><creator>van Oosten, Marleen</creator><creator>Schäfer, Tina</creator><creator>Gazendam, Joost A. C.</creator><creator>Ohlsen, Knut</creator><creator>Tsompanidou, Eleni</creator><creator>de Goffau, Marcus C.</creator><creator>Harmsen, Hermie J. M.</creator><creator>Crane, Lucia M. A.</creator><creator>Lim, Ed</creator><creator>Francis, Kevin P.</creator><creator>Cheung, Lael</creator><creator>Olive, Michael</creator><creator>Ntziachristos, Vasilis</creator><creator>van Dijl, Jan Maarten</creator><creator>van Dam, Gooitzen M.</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7QP</scope><scope>7QR</scope><scope>7SN</scope><scope>7SS</scope><scope>7ST</scope><scope>7T5</scope><scope>7T7</scope><scope>7TM</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>RC3</scope><scope>SOI</scope><scope>7X8</scope></search><sort><creationdate>20131015</creationdate><title>Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin</title><author>van Oosten, Marleen ; Schäfer, Tina ; Gazendam, Joost A. C. ; Ohlsen, Knut ; Tsompanidou, Eleni ; de Goffau, Marcus C. ; Harmsen, Hermie J. M. ; Crane, Lucia M. A. ; Lim, Ed ; Francis, Kevin P. ; Cheung, Lael ; Olive, Michael ; Ntziachristos, Vasilis ; van Dijl, Jan Maarten ; van Dam, Gooitzen M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c387t-ff5899d24a196b0efbd93d5d1dd8a615bc2892f848d8431b55032e908fb6cdde3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/1647/245</topic><topic>692/308</topic><topic>692/699/255/1318</topic><topic>692/700/139</topic><topic>Animals</topic><topic>Anti-Bacterial Agents - chemistry</topic><topic>Benzenesulfonates - chemistry</topic><topic>Biocompatible Materials - adverse effects</topic><topic>Cadaver</topic><topic>Diagnostic Imaging - methods</topic><topic>Disease Models, Animal</topic><topic>Fluorescent Dyes - chemistry</topic><topic>Gram-Positive Bacteria - growth & development</topic><topic>Gram-Positive Bacterial Infections - diagnosis</topic><topic>Gram-Positive Bacterial Infections - microbiology</topic><topic>Humanities and Social Sciences</topic><topic>Humans</topic><topic>Image Interpretation, Computer-Assisted</topic><topic>Indoles - chemistry</topic><topic>Mice</topic><topic>multidisciplinary</topic><topic>Myositis - diagnosis</topic><topic>Myositis - microbiology</topic><topic>Science</topic><topic>Science (multidisciplinary)</topic><topic>Time Factors</topic><topic>Vancomycin - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>van Oosten, Marleen</creatorcontrib><creatorcontrib>Schäfer, Tina</creatorcontrib><creatorcontrib>Gazendam, Joost A. C.</creatorcontrib><creatorcontrib>Ohlsen, Knut</creatorcontrib><creatorcontrib>Tsompanidou, Eleni</creatorcontrib><creatorcontrib>de Goffau, Marcus C.</creatorcontrib><creatorcontrib>Harmsen, Hermie J. M.</creatorcontrib><creatorcontrib>Crane, Lucia M. A.</creatorcontrib><creatorcontrib>Lim, Ed</creatorcontrib><creatorcontrib>Francis, Kevin P.</creatorcontrib><creatorcontrib>Cheung, Lael</creatorcontrib><creatorcontrib>Olive, Michael</creatorcontrib><creatorcontrib>Ntziachristos, Vasilis</creatorcontrib><creatorcontrib>van Dijl, Jan Maarten</creatorcontrib><creatorcontrib>van Dam, Gooitzen M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Ecology Abstracts</collection><collection>Entomology Abstracts (Full archive)</collection><collection>Environment Abstracts</collection><collection>Immunology Abstracts</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>Advanced Technologies & Aerospace Database (1962 - current)</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>PML(ProQuest Medical Library)</collection><collection>Biological Science Database</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>Genetics Abstracts</collection><collection>Environment Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Nature communications</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext_linktorsrc</fulltext></delivery><addata><au>van Oosten, Marleen</au><au>Schäfer, Tina</au><au>Gazendam, Joost A. C.</au><au>Ohlsen, Knut</au><au>Tsompanidou, Eleni</au><au>de Goffau, Marcus C.</au><au>Harmsen, Hermie J. M.</au><au>Crane, Lucia M. A.</au><au>Lim, Ed</au><au>Francis, Kevin P.</au><au>Cheung, Lael</au><au>Olive, Michael</au><au>Ntziachristos, Vasilis</au><au>van Dijl, Jan Maarten</au><au>van Dam, Gooitzen M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin</atitle><jtitle>Nature communications</jtitle><stitle>Nat Commun</stitle><addtitle>Nat Commun</addtitle><date>2013-10-15</date><risdate>2013</risdate><volume>4</volume><issue>1</issue><spage>2584</spage><epage>2584</epage><pages>2584-2584</pages><artnum>2584</artnum><issn>2041-1723</issn><eissn>2041-1723</eissn><abstract>Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, guided by recent advances in clinically relevant optical imaging technologies, we explore the use of fluorescently labelled vancomycin (vanco-800CW) to specifically target and detect infections caused by Gram-positive bacteria. The application potential of vanco-800CW for real-time
in vivo
imaging of bacterial infections is assessed in a mouse myositis model and a human
post-mortem
implant model. We show that vanco-800CW can specifically detect Gram-positive bacterial infections in our mouse myositis model, discriminate bacterial infections from sterile inflammation
in vivo
and detect biomaterial-associated infections in the lower leg of a human cadaver. We conclude that vanco-800CW has a high potential for enhanced non-invasive diagnosis of infections with Gram-positive bacteria and is a promising candidate for early-phase clinical trials.
Invasive and biomaterial-associated infections in humans are often difficult to diagnose and treat. Here, the authors demonstrate that real-time
in vivo
detection and imaging of these bacterial infections can be successfully performed with fluorescently labelled vancomycin.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>24129412</pmid><doi>10.1038/ncomms3584</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext_linktorsrc |
| identifier | ISSN: 2041-1723 |
| ispartof | Nature communications, 2013-10, Vol.4 (1), p.2584-2584, Article 2584 |
| issn | 2041-1723 2041-1723 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1443428712 |
| source | Springer Open Access |
| subjects | 631/1647/245 692/308 692/699/255/1318 692/700/139 Animals Anti-Bacterial Agents - chemistry Benzenesulfonates - chemistry Biocompatible Materials - adverse effects Cadaver Diagnostic Imaging - methods Disease Models, Animal Fluorescent Dyes - chemistry Gram-Positive Bacteria - growth & development Gram-Positive Bacterial Infections - diagnosis Gram-Positive Bacterial Infections - microbiology Humanities and Social Sciences Humans Image Interpretation, Computer-Assisted Indoles - chemistry Mice multidisciplinary Myositis - diagnosis Myositis - microbiology Science Science (multidisciplinary) Time Factors Vancomycin - chemistry |
| title | Real-time in vivo imaging of invasive- and biomaterial-associated bacterial infections using fluorescently labelled vancomycin |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-02T18%3A47%3A23IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_C6C&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Real-time%20in%20vivo%20imaging%20of%20invasive-%20and%20biomaterial-associated%20bacterial%20infections%20using%20fluorescently%20labelled%20vancomycin&rft.jtitle=Nature%20communications&rft.au=van%20Oosten,%20Marleen&rft.date=2013-10-15&rft.volume=4&rft.issue=1&rft.spage=2584&rft.epage=2584&rft.pages=2584-2584&rft.artnum=2584&rft.issn=2041-1723&rft.eissn=2041-1723&rft_id=info:doi/10.1038/ncomms3584&rft_dat=%3Cproquest_C6C%3E3098893941%3C/proquest_C6C%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1441891272&rft_id=info:pmid/24129412&rfr_iscdi=true |