Warfarin Induces Cardiovascular Damage in Mice

OBJECTIVE—Vascular calcification is an independent risk factor for cardiovascular disease. Once thought to be a passive process, vascular calcification is now known to be actively prevented by proteins acting systemically (fetuin-A) or locally (matrix Gla protein). Warfarin is a vitamin K antagonist...

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Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-11, Vol.33 (11), p.2618-2624
Hauptverfasser:	Krüger, Thilo, Oelenberg, Stephan, Kaesler, Nadine, Schurgers, Leon J, van de Sandt, Annette M, Boor, Peter, Schlieper, Georg, Brandenburg, Vincent M, Fekete, Bertalan C, Veulemans, Verena, Ketteler, Markus, Vermeer, Cees, Jahnen-Dechent, Willi, Floege, Jürgen, Westenfeld, Ralf
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anticoagulants - pharmacology Antifibrinolytic Agents - pharmacology Aorta - drug effects Aorta - pathology Apoptosis - drug effects Calcium - metabolism Disease Models, Animal Dose-Response Relationship, Drug Drug Interactions Mice Mice, Inbred C57BL Mice, Inbred DBA Muscle, Smooth, Vascular - drug effects Muscle, Smooth, Vascular - pathology Pulsatile Flow - drug effects Pulsatile Flow - physiology Risk Factors Vascular Calcification - chemically induced Vascular Calcification - epidemiology Vascular Calcification - pathology Vitamin K 1 - pharmacology Vitamin K 2 - pharmacology Warfarin - pharmacology
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