Disruption of the Bone Morphogenetic Protein Receptor 2 Pathway in Nitrofen-Induced Congenital Diaphragmatic Hernia

BACKGROUND/PURPOSE Congenital diaphragmatic hernia (CDH) remains a major therapeutic challenge despite advances in neonatal resuscitation and intensive care. The high mortality and morbidity in CDH has been attributed to pulmonary hypoplasia and persistent pulmonary hypertension (PH). Bone morphogen...

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Veröffentlicht in:	Birth defects research. Part B. Developmental and reproductive toxicology 2013-08, Vol.98 (4), p.304-309
Hauptverfasser:	Gosemann, Jan-Hendrik, Friedmacher, Florian, Fujiwara, Naho, Alvarez, Luis A. J., Corcionivoschi, Nicolae, Puri, Prem
Format:	Artikel
Sprache:	eng
Schlagworte:	Actins - metabolism Animals Biological and medical sciences Blotting, Western BMPR2 Bone Morphogenetic Protein Receptors, Type II - genetics Bone Morphogenetic Protein Receptors, Type II - metabolism congenital diaphragmatic hernia Embryology: invertebrates and vertebrates. Teratology Female Fluorescent Antibody Technique Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Regulation, Developmental - drug effects Hernia, Diaphragmatic - chemically induced Hernia, Diaphragmatic - genetics Hernia, Diaphragmatic - metabolism Hernia, Diaphragmatic - pathology Hernias Hernias, Diaphragmatic, Congenital Humans Lung - drug effects Lung - metabolism Lung - pathology Lungs Medical sciences Muscular system nitrofen p38 Mitogen-Activated Protein Kinases - metabolism Pesticides, fertilizers and other agrochemicals toxicology Phenyl Ethers - toxicity Phosphotyrosine - metabolism Pneumology Pregnancy Proteins pulmonary hypertension Pulmonary hypertension. Acute cor pulmonale. Pulmonary embolism. Pulmonary vascular diseases Rats Rats, Sprague-Dawley Real-Time Polymerase Chain Reaction RNA, Messenger - genetics RNA, Messenger - metabolism Rodents Signal Transduction - drug effects Smad Proteins - metabolism Smooth muscle Teratology. Teratogens Toxicology
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