Effects of Maternal Exposure to Imazalil on Behavioral Development in F1-Generation Mice
Female mice were exposed maternally to imazalil through diet to provide levels of 0 (control), 0.0006, 0.0018, and 0.0054% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in F1 generation. There was no adverse effect of imazalil on litte...
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| Veröffentlicht in: | Birth defects research. Part B. Developmental and reproductive toxicology 2013-08, Vol.98 (4), p.334-342 |
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| container_title | Birth defects research. Part B. Developmental and reproductive toxicology |
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| creator | Tanaka, Toyohito Ogata, Akio Inomata, Akiko Nakae, Dai |
| description | Female mice were exposed maternally to imazalil through diet to provide levels of 0 (control), 0.0006, 0.0018, and 0.0054% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in F1 generation. There was no adverse effect of imazalil on litter size, litter weight, or sex ratio at birth. With respect to behavioral developmental parameters, surface righting on postnatal day 4 of male offspring was delayed significantly in a dose‐related manner (p < 0.05). Regarding exploratory behavior in the F1 generation, movement time was significantly long (p = 0.0206) in the low‐dose group of males at 8 weeks of age. Spontaneous behavior examination in males indicated that movement time increased but in females decreased in the low‐dose groups in the F1 generation. The dose levels of imazalil in the present study produced some adverse effects in neurobehavioral parameters in mice. |
| doi_str_mv | 10.1002/bdrb.21070 |
| format | Article |
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There was no adverse effect of imazalil on litter size, litter weight, or sex ratio at birth. With respect to behavioral developmental parameters, surface righting on postnatal day 4 of male offspring was delayed significantly in a dose‐related manner (p < 0.05). Regarding exploratory behavior in the F1 generation, movement time was significantly long (p = 0.0206) in the low‐dose group of males at 8 weeks of age. Spontaneous behavior examination in males indicated that movement time increased but in females decreased in the low‐dose groups in the F1 generation. The dose levels of imazalil in the present study produced some adverse effects in neurobehavioral parameters in mice.</description><identifier>ISSN: 1542-9733</identifier><identifier>EISSN: 1542-9741</identifier><identifier>DOI: 10.1002/bdrb.21070</identifier><identifier>PMID: 24039133</identifier><identifier>CODEN: BDRPCU</identifier><language>eng</language><publisher>Hoboken, NJ: Blackwell Publishing Ltd</publisher><subject>Animals ; Behavior ; Behavior, Animal - drug effects ; behavioral development ; Biological and medical sciences ; Body Weight - drug effects ; Crosses, Genetic ; Drug toxicity and drugs side effects treatment ; Embryology: invertebrates and vertebrates. Teratology ; enilconazole ; Exploratory Behavior - drug effects ; Feeding Behavior - drug effects ; Female ; Fundamental and applied biological sciences. Psychology ; fungicide ; imazalil ; Imidazoles - administration & dosage ; Imidazoles - toxicity ; Lactation - drug effects ; Male ; maternal exposure ; Maze Learning - drug effects ; Medical research ; Medical sciences ; Mice ; Miscellaneous (drug allergy, mutagens, teratogens...) ; Movement - drug effects ; movement activity ; Pesticides, fertilizers and other agrochemicals toxicology ; Pharmacology. Drug treatments ; Pregnancy ; Prenatal Exposure Delayed Effects - pathology ; reproductive toxicity ; Rodents ; spontaneous behavior ; Survival Analysis ; Teratology. Teratogens ; Toxicology ; Weaning</subject><ispartof>Birth defects research. Part B. Developmental and reproductive toxicology, 2013-08, Vol.98 (4), p.334-342</ispartof><rights>2013 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbdrb.21070$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbdrb.21070$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1413,27906,27907,45556,45557</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27830522$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24039133$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tanaka, Toyohito</creatorcontrib><creatorcontrib>Ogata, Akio</creatorcontrib><creatorcontrib>Inomata, Akiko</creatorcontrib><creatorcontrib>Nakae, Dai</creatorcontrib><title>Effects of Maternal Exposure to Imazalil on Behavioral Development in F1-Generation Mice</title><title>Birth defects research. Part B. Developmental and reproductive toxicology</title><addtitle>Birth Defects Res B</addtitle><description>Female mice were exposed maternally to imazalil through diet to provide levels of 0 (control), 0.0006, 0.0018, and 0.0054% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in F1 generation. There was no adverse effect of imazalil on litter size, litter weight, or sex ratio at birth. With respect to behavioral developmental parameters, surface righting on postnatal day 4 of male offspring was delayed significantly in a dose‐related manner (p < 0.05). Regarding exploratory behavior in the F1 generation, movement time was significantly long (p = 0.0206) in the low‐dose group of males at 8 weeks of age. Spontaneous behavior examination in males indicated that movement time increased but in females decreased in the low‐dose groups in the F1 generation. The dose levels of imazalil in the present study produced some adverse effects in neurobehavioral parameters in mice.</description><subject>Animals</subject><subject>Behavior</subject><subject>Behavior, Animal - drug effects</subject><subject>behavioral development</subject><subject>Biological and medical sciences</subject><subject>Body Weight - drug effects</subject><subject>Crosses, Genetic</subject><subject>Drug toxicity and drugs side effects treatment</subject><subject>Embryology: invertebrates and vertebrates. Teratology</subject><subject>enilconazole</subject><subject>Exploratory Behavior - drug effects</subject><subject>Feeding Behavior - drug effects</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>fungicide</subject><subject>imazalil</subject><subject>Imidazoles - administration & dosage</subject><subject>Imidazoles - toxicity</subject><subject>Lactation - drug effects</subject><subject>Male</subject><subject>maternal exposure</subject><subject>Maze Learning - drug effects</subject><subject>Medical research</subject><subject>Medical sciences</subject><subject>Mice</subject><subject>Miscellaneous (drug allergy, mutagens, teratogens...)</subject><subject>Movement - drug effects</subject><subject>movement activity</subject><subject>Pesticides, fertilizers and other agrochemicals toxicology</subject><subject>Pharmacology. Drug treatments</subject><subject>Pregnancy</subject><subject>Prenatal Exposure Delayed Effects - pathology</subject><subject>reproductive toxicity</subject><subject>Rodents</subject><subject>spontaneous behavior</subject><subject>Survival Analysis</subject><subject>Teratology. Teratogens</subject><subject>Toxicology</subject><subject>Weaning</subject><issn>1542-9733</issn><issn>1542-9741</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0Utv1DAQAGALgWi7cOEHoEgIqZe0tieOvUe23YZK24JQEb1Zk-xYuOSx2Elfv57sg0Xi5LH8jTUPxt4JfiI4l6flMpQnUnDNX7BDoTKZTnUmXu5jgAN2FOPdaEFr85odyIzDVAAcstu5c1T1MelccoU9hRbrZP646uIQKOm75LLBZ6x9nXRtMqOfeO-7MJJzuqe6WzXU9olvkwuRFtRSwN6P7spX9Ia9clhHers7J-z7xfzm7HO6-FJcnn1apB6A85SWaIQqpcuRg3PApSRV5kpJCYaLUhJJKpXRZQZOGjfelijysSlURgqECTve_rsK3e-BYm8bHyuqa2ypG6IVWQaZVABqpB_-o3fdsG54o4TReTYOZcLe79RQNrS0q-AbDE_278xG8HEHMFZYu4Bt5eM_pw3wdfkTJrbuwdf0tH8X3K63Ztdbs5ut2dn5t9kmGnPSbY6PPT3uczD8srkGreyP68JOF1-L4uaWWwN_AH2AlnA</recordid><startdate>201308</startdate><enddate>201308</enddate><creator>Tanaka, Toyohito</creator><creator>Ogata, Akio</creator><creator>Inomata, Akiko</creator><creator>Nakae, Dai</creator><general>Blackwell Publishing Ltd</general><general>Wiley-Liss</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201308</creationdate><title>Effects of Maternal Exposure to Imazalil on Behavioral Development in F1-Generation Mice</title><author>Tanaka, Toyohito ; Ogata, Akio ; Inomata, Akiko ; Nakae, Dai</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-i3300-eda815b2f6a03ff3022e5b655223801b2ee2eb587b43f28fe2eda16973a5821a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Behavior</topic><topic>Behavior, Animal - drug effects</topic><topic>behavioral development</topic><topic>Biological and medical sciences</topic><topic>Body Weight - drug effects</topic><topic>Crosses, Genetic</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Embryology: invertebrates and vertebrates. Teratology</topic><topic>enilconazole</topic><topic>Exploratory Behavior - drug effects</topic><topic>Feeding Behavior - drug effects</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>fungicide</topic><topic>imazalil</topic><topic>Imidazoles - administration & dosage</topic><topic>Imidazoles - toxicity</topic><topic>Lactation - drug effects</topic><topic>Male</topic><topic>maternal exposure</topic><topic>Maze Learning - drug effects</topic><topic>Medical research</topic><topic>Medical sciences</topic><topic>Mice</topic><topic>Miscellaneous (drug allergy, mutagens, teratogens...)</topic><topic>Movement - drug effects</topic><topic>movement activity</topic><topic>Pesticides, fertilizers and other agrochemicals toxicology</topic><topic>Pharmacology. Drug treatments</topic><topic>Pregnancy</topic><topic>Prenatal Exposure Delayed Effects - pathology</topic><topic>reproductive toxicity</topic><topic>Rodents</topic><topic>spontaneous behavior</topic><topic>Survival Analysis</topic><topic>Teratology. Teratogens</topic><topic>Toxicology</topic><topic>Weaning</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tanaka, Toyohito</creatorcontrib><creatorcontrib>Ogata, Akio</creatorcontrib><creatorcontrib>Inomata, Akiko</creatorcontrib><creatorcontrib>Nakae, Dai</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Birth defects research. Part B. Developmental and reproductive toxicology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tanaka, Toyohito</au><au>Ogata, Akio</au><au>Inomata, Akiko</au><au>Nakae, Dai</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Maternal Exposure to Imazalil on Behavioral Development in F1-Generation Mice</atitle><jtitle>Birth defects research. Part B. Developmental and reproductive toxicology</jtitle><addtitle>Birth Defects Res B</addtitle><date>2013-08</date><risdate>2013</risdate><volume>98</volume><issue>4</issue><spage>334</spage><epage>342</epage><pages>334-342</pages><issn>1542-9733</issn><eissn>1542-9741</eissn><coden>BDRPCU</coden><abstract>Female mice were exposed maternally to imazalil through diet to provide levels of 0 (control), 0.0006, 0.0018, and 0.0054% during gestation and lactation periods, and selected reproductive and neurobehavioral parameters were measured in F1 generation. There was no adverse effect of imazalil on litter size, litter weight, or sex ratio at birth. With respect to behavioral developmental parameters, surface righting on postnatal day 4 of male offspring was delayed significantly in a dose‐related manner (p < 0.05). Regarding exploratory behavior in the F1 generation, movement time was significantly long (p = 0.0206) in the low‐dose group of males at 8 weeks of age. 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| subjects | Animals Behavior Behavior, Animal - drug effects behavioral development Biological and medical sciences Body Weight - drug effects Crosses, Genetic Drug toxicity and drugs side effects treatment Embryology: invertebrates and vertebrates. Teratology enilconazole Exploratory Behavior - drug effects Feeding Behavior - drug effects Female Fundamental and applied biological sciences. Psychology fungicide imazalil Imidazoles - administration & dosage Imidazoles - toxicity Lactation - drug effects Male maternal exposure Maze Learning - drug effects Medical research Medical sciences Mice Miscellaneous (drug allergy, mutagens, teratogens...) Movement - drug effects movement activity Pesticides, fertilizers and other agrochemicals toxicology Pharmacology. Drug treatments Pregnancy Prenatal Exposure Delayed Effects - pathology reproductive toxicity Rodents spontaneous behavior Survival Analysis Teratology. Teratogens Toxicology Weaning |
| title | Effects of Maternal Exposure to Imazalil on Behavioral Development in F1-Generation Mice |
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