Effects of cytochrome P450 inhibitors and inducers on the metabolism and pharmacokinetics of ospemifene

ABSTRACT Purpose: The objectives were to determine the cytochrome P450 (CYP) enzymes involved in the metabolism of ospemifene and its main hydroxylated metabolites and to examine the effects of CYP inhibitors and inducers on ospemifene pharmacokinetics. Methods: In vitro metabolism studies were cond...

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Veröffentlicht in:	Biopharmaceutics & drug disposition 2013-10, Vol.34 (7), p.387-395
Hauptverfasser:	Lehtinen, Terhi, Tolonen, Ari, Turpeinen, Miia, Uusitalo, Jouko, Vuorinen, Jouni, Lammintausta, Risto, Pelkonen, Olavi, Scheinin, Mika
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Biological and medical sciences Cross-Over Studies Cytochrome P-450 Enzyme Inhibitors Cytochrome P-450 Enzyme System - metabolism Digestive system Drug Interactions Enzyme Inhibitors - administration & dosage Estrogen Receptor Modulators - administration & dosage Estrogen Receptor Modulators - blood Estrogen Receptor Modulators - pharmacokinetics Female fluconazole Humans ketoconazole Ketoconazole - administration & dosage Medical sciences Microsomes, Liver - drug effects Microsomes, Liver - metabolism Middle Aged omeprazole Pharmacology. Drug treatments Postmenopause rifampicin Rifampin - administration & dosage selective estrogen receptor modulator Tamoxifen - administration & dosage Tamoxifen - analogs & derivatives Tamoxifen - blood Tamoxifen - pharmacokinetics
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