Polycomb repressive complex 2 (PRC2) suppresses Eμ-myc lymphoma

Deregulation of polycomb group complexes polycomb repressive complex 1 (PRC1) and 2 (PRC2) is associated with human cancers. Although inactivating mutations in PRC2-encoding genes EZH2, EED, and SUZ12 are present in T-cell acute lymphoblastic leukemia and in myeloid malignancies, gain-of-function mu...

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Veröffentlicht in:	Blood 2013-10, Vol.122 (15), p.2654-2663
Hauptverfasser:	Lee, Stanley C.W., Phipson, Belinda, Hyland, Craig D., Leong, Huei San, Allan, Rhys S., Lun, Aaron, Hilton, Douglas J., Nutt, Stephen L., Blewitt, Marnie E., Smyth, Gordon K., Alexander, Warren S., Majewski, Ian J.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals B-Lymphocytes - cytology B-Lymphocytes - physiology Cells, Cultured Enhancer of Zeste Homolog 2 Protein Gene Expression Regulation, Neoplastic - physiology Lymphoma, B-Cell - genetics Lymphoma, B-Cell - metabolism Lymphoma, B-Cell - pathology Lymphopoiesis - genetics Mice Mice, Inbred C57BL Mice, Transgenic Polycomb Repressive Complex 1 - genetics Polycomb Repressive Complex 1 - metabolism Polycomb Repressive Complex 2 - genetics Polycomb Repressive Complex 2 - metabolism Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - genetics Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - metabolism Precursor T-Cell Lymphoblastic Leukemia-Lymphoma - pathology Proto-Oncogene Proteins c-myc - genetics Proto-Oncogene Proteins c-myc - metabolism
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