Modulation of albumin-induced endoplasmic reticulum stress in renal proximal tubule cells by upregulation of mapk phosphatase-1

•Albumin rapidly increases both MKP-1 mRNA and protein levels.•The effect of albumin on MKP-1 mRNA levels is due to gene transcription activation.•Albumin induces MKP-1 protein accumulation promoting its stabilization.•Albumin induces GRP78 mRNA through an ERK-dependent mechanism.•MKP-1 induction do...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Chemico-biological interactions 2013-10, Vol.206 (1), p.47-54
Hauptverfasser:	Gorostizaga, Alejandra, Mori Sequeiros García, Maria Mercedes, Acquier, Andrea, Gomez, Natalia V., Maloberti, Paula M., Mendez, Carlos F., Paz, Cristina
Format:	Artikel
Sprache:	eng
Schlagworte:	adverse effects Albumin albumins Animals Cattle Cells, Cultured dephosphorylation Didelphis - metabolism Dual Specificity Phosphatase 1 - genetics Dual Specificity Phosphatase 1 - metabolism endoplasmic reticulum Endoplasmic Reticulum - metabolism Endoplasmic reticulum stress ERK1/2 gene activation kidney cells Kidney Tubules, Proximal - cytology Kidney Tubules, Proximal - metabolism messenger RNA mitogen-activated protein kinase MKPs OK cells Oxidative Stress phosphorylation renal function Reverse Transcriptase Polymerase Chain Reaction Serum Albumin, Bovine - metabolism stress response transcription (genetics) Up-Regulation urine
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!