Alpha-adrenoceptor antagonists and chemical sympathectomy exacerbate anaphylaxis-induced hypotension, but not portal hypertension, in anesthetized rats

Anaphylactic shock is sometimes life-threatening, and it is accompanied by hepatic venoconstriction in animals, which, in part, accounts for anaphylactic hypotension. Roles of norepinephrine and α-adrenoceptor in anaphylaxis-induced hypotension and portal hypertension were investigated in anesthetiz...

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Veröffentlicht in:	American journal of physiology. Regulatory, integrative and comparative physiology integrative and comparative physiology, 2013-10, Vol.305 (8), p.R900-R907
Hauptverfasser:	Wang, Mofei, Tanida, Mamoru, Shibamoto, Toshishige, Kurata, Yasutaka
Format:	Artikel
Sprache:	eng
Schlagworte:	Adrenergic alpha-1 Receptor Antagonists - pharmacology Anaphylaxis - complications Anaphylaxis - physiopathology Animals Antagonist drugs Blood pressure Drug therapy Hypertension, Portal - etiology Hypertension, Portal - physiopathology Hypotension - etiology Hypotension - physiopathology Liver Circulation - drug effects Liver Circulation - physiology Male Oxidopamine Pharmacology Phentolamine - pharmacology Physiology Portal Pressure - drug effects Prazosin - pharmacology Rats Rats, Sprague-Dawley Sympathectomy, Chemical Vascular Resistance - drug effects
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