Structural characterization of an immunoenhancing glucan isolated from a mushroom Macrolepiota dolichaula

•A soluble branched β-d-glucan (PS-I) was isolated from the mushroom M. dolichaula.•Structure of the PS-I was determined by chemical as well as 1D/2D NMR studies.•The PS-I showed in vitro macrophage activation.•It also showed splenocyte and thymocyte activation in mouse cell culture medium. A water...

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Veröffentlicht in:	International journal of biological macromolecules 2013-10, Vol.61, p.89-96
Hauptverfasser:	Samanta, Surajit, Nandi, Ashis K., Sen, Ipsita K., Maji, Praloy K., Devi, K. Sanjana P., Maiti, Tapas K., Islam, Syed S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Agaricales - chemistry Animals Branched glucan cell culture Cell Line culture media Dose-Response Relationship, Drug fruit extracts fruiting bodies glucans Glucans - chemistry Glucans - isolation & purification Glucans - pharmacology hydrolysis Immunoactivation Immunologic Factors - chemistry Immunologic Factors - isolation & purification Immunologic Factors - pharmacology Macrolepiota Macrolepiota dolichaula macrophage activation Macrophage Activation - drug effects Macrophage Activation - immunology Macrophages - drug effects Macrophages - immunology methylation Mice molecular weight mushrooms NMR studies nuclear magnetic resonance spectroscopy Nuclear Magnetic Resonance, Biomolecular thymocytes
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