Distribution of grape seed flavanols and their metabolites in pregnant rats and their fetuses
Scope Polyphenols have been demonstrated to provide health benefits affecting cellular and physiological processes. This study aims to evaluate the bioavailability and distribution of grape seed flavanol compounds during pregnancy and whether fetuses could be exposed to these compounds. Methods and...
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| Veröffentlicht in: | Molecular nutrition & food research 2013-10, Vol.57 (10), p.1741-1752 |
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| creator | Arola-Arnal, Anna Oms-Oliu, Gemma Crescenti, Anna del Bas, Josep Maria Ras, Maria Rosa Arola, Lluís Caimari, Antoni |
| description | Scope
Polyphenols have been demonstrated to provide health benefits affecting cellular and physiological processes. This study aims to evaluate the bioavailability and distribution of grape seed flavanol compounds during pregnancy and whether fetuses could be exposed to these compounds.
Methods and results
The distribution of flavanols and their metabolites in rat plasma, liver, white adipose tissue, brain, amniotic fluid, placenta, and fetuses after 1 and 2 h of an acute intake of a grape seed proanthocyanidin extract was examined by LC‐ESI‐TOF/MS. Flavanols and their metabolites were widely distributed in both pregnant and nonpregnant rat plasma and tissues. In liver, the conjugated forms of flavanols were less available in pregnant than nonpregnant rats. Flavanol metabolites were abundant in maternal placenta but detected at low levels in fetuses and amniotic fluid.
Conclusion
Flavanol metabolization appears to be less active in the liver during pregnancy. Moreover, data indicated that transport across the placenta is not efficient and for flavanols and their metabolites, the placenta seems to act as a barrier. However, these compounds target the fetus and are excreted in the amniotic fluid. |
| doi_str_mv | 10.1002/mnfr.201300032 |
| format | Article |
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Polyphenols have been demonstrated to provide health benefits affecting cellular and physiological processes. This study aims to evaluate the bioavailability and distribution of grape seed flavanol compounds during pregnancy and whether fetuses could be exposed to these compounds.
Methods and results
The distribution of flavanols and their metabolites in rat plasma, liver, white adipose tissue, brain, amniotic fluid, placenta, and fetuses after 1 and 2 h of an acute intake of a grape seed proanthocyanidin extract was examined by LC‐ESI‐TOF/MS. Flavanols and their metabolites were widely distributed in both pregnant and nonpregnant rat plasma and tissues. In liver, the conjugated forms of flavanols were less available in pregnant than nonpregnant rats. Flavanol metabolites were abundant in maternal placenta but detected at low levels in fetuses and amniotic fluid.
Conclusion
Flavanol metabolization appears to be less active in the liver during pregnancy. Moreover, data indicated that transport across the placenta is not efficient and for flavanols and their metabolites, the placenta seems to act as a barrier. However, these compounds target the fetus and are excreted in the amniotic fluid.</description><identifier>ISSN: 1613-4125</identifier><identifier>EISSN: 1613-4133</identifier><identifier>DOI: 10.1002/mnfr.201300032</identifier><identifier>PMID: 23728968</identifier><language>eng</language><publisher>Weinheim: Blackwell Publishing Ltd</publisher><subject>Adipose Tissue - drug effects ; Adipose Tissue - metabolism ; Amniotic fluid ; Amniotic Fluid - drug effects ; Amniotic Fluid - metabolism ; Animals ; Bioavailability ; Biological and medical sciences ; Biological Availability ; Brain - drug effects ; Brain - metabolism ; Chromatography, Liquid ; Feeding. Feeding behavior ; Female ; Fetus - drug effects ; Fetus - metabolism ; Fundamental and applied biological sciences. Psychology ; Grape Seed Extract - administration & dosage ; Grape Seed Extract - pharmacokinetics ; Liver - drug effects ; Liver - metabolism ; Male ; Mass Spectrometry ; Placenta ; Placenta - drug effects ; Placenta - metabolism ; Polyphenols ; Polyphenols - administration & dosage ; Polyphenols - pharmacokinetics ; Pregnancy ; Proanthocyanidins ; Proanthocyanidins - administration & dosage ; Proanthocyanidins - pharmacokinetics ; Rats ; Rats, Wistar ; Reproducibility of Results ; Seeds - chemistry ; Vertebrates: anatomy and physiology, studies on body, several organs or systems ; Vitis - chemistry</subject><ispartof>Molecular nutrition & food research, 2013-10, Vol.57 (10), p.1741-1752</ispartof><rights>2013 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2014 INIST-CNRS</rights><rights>2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4085-f077cd989421583d52ccc5bfdcc084fe5f3b8872b319e98116ea6a24b45727a3</citedby><cites>FETCH-LOGICAL-c4085-f077cd989421583d52ccc5bfdcc084fe5f3b8872b319e98116ea6a24b45727a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fmnfr.201300032$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fmnfr.201300032$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27816275$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23728968$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Arola-Arnal, Anna</creatorcontrib><creatorcontrib>Oms-Oliu, Gemma</creatorcontrib><creatorcontrib>Crescenti, Anna</creatorcontrib><creatorcontrib>del Bas, Josep Maria</creatorcontrib><creatorcontrib>Ras, Maria Rosa</creatorcontrib><creatorcontrib>Arola, Lluís</creatorcontrib><creatorcontrib>Caimari, Antoni</creatorcontrib><title>Distribution of grape seed flavanols and their metabolites in pregnant rats and their fetuses</title><title>Molecular nutrition & food research</title><addtitle>Mol. Nutr. Food Res</addtitle><description>Scope
Polyphenols have been demonstrated to provide health benefits affecting cellular and physiological processes. This study aims to evaluate the bioavailability and distribution of grape seed flavanol compounds during pregnancy and whether fetuses could be exposed to these compounds.
Methods and results
The distribution of flavanols and their metabolites in rat plasma, liver, white adipose tissue, brain, amniotic fluid, placenta, and fetuses after 1 and 2 h of an acute intake of a grape seed proanthocyanidin extract was examined by LC‐ESI‐TOF/MS. Flavanols and their metabolites were widely distributed in both pregnant and nonpregnant rat plasma and tissues. In liver, the conjugated forms of flavanols were less available in pregnant than nonpregnant rats. Flavanol metabolites were abundant in maternal placenta but detected at low levels in fetuses and amniotic fluid.
Conclusion
Flavanol metabolization appears to be less active in the liver during pregnancy. Moreover, data indicated that transport across the placenta is not efficient and for flavanols and their metabolites, the placenta seems to act as a barrier. However, these compounds target the fetus and are excreted in the amniotic fluid.</description><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Amniotic fluid</subject><subject>Amniotic Fluid - drug effects</subject><subject>Amniotic Fluid - metabolism</subject><subject>Animals</subject><subject>Bioavailability</subject><subject>Biological and medical sciences</subject><subject>Biological Availability</subject><subject>Brain - drug effects</subject><subject>Brain - metabolism</subject><subject>Chromatography, Liquid</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fetus - drug effects</subject><subject>Fetus - metabolism</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Grape Seed Extract - administration & dosage</subject><subject>Grape Seed Extract - pharmacokinetics</subject><subject>Liver - drug effects</subject><subject>Liver - metabolism</subject><subject>Male</subject><subject>Mass Spectrometry</subject><subject>Placenta</subject><subject>Placenta - drug effects</subject><subject>Placenta - metabolism</subject><subject>Polyphenols</subject><subject>Polyphenols - administration & dosage</subject><subject>Polyphenols - pharmacokinetics</subject><subject>Pregnancy</subject><subject>Proanthocyanidins</subject><subject>Proanthocyanidins - administration & dosage</subject><subject>Proanthocyanidins - pharmacokinetics</subject><subject>Rats</subject><subject>Rats, Wistar</subject><subject>Reproducibility of Results</subject><subject>Seeds - chemistry</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><subject>Vitis - chemistry</subject><issn>1613-4125</issn><issn>1613-4133</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0c1rFDEYBvAgiv3Qq0fJRfAy23xOMkdZbavUFUqhIEjIZN7U6Exmm2Ss_e-dZbdrbz29Ofye94UnCL2hZEEJYSdD9GnBCOWEEM6eoUNaU14Jyvnz_ZvJA3SU869ZUCb4S3TAuGK6qfUh-vEx5JJCO5UwRjx6fJPsGnAG6LDv7R8bxz5jGztcfkJIeIBi27EPBTIOEa8T3EQbC062PGYeypQhv0IvvO0zvN7NY3R1-ulqeV5dfDv7vPxwUTlBtKw8Ucp1jW4Eo1LzTjLnnGx95xzRwoP0vNVasZbTBhpNaQ22tky0QiqmLD9G77dr12m8nSAXM4TsoO9thHHKhgrBBZW8oTNdbKlLY84JvFmnMNh0bygxm0bNplGzb3QOvN3tntoBuj1_qHAG73bAZmd7n2x0If93StOaKTk7sXV3oYf7J86ar6vTS9o0m1i1jc3_BH_3MZt-m1pxJc316sysvi_P5Zfltbnk_wCNUp5d</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Arola-Arnal, Anna</creator><creator>Oms-Oliu, Gemma</creator><creator>Crescenti, Anna</creator><creator>del Bas, Josep Maria</creator><creator>Ras, Maria Rosa</creator><creator>Arola, Lluís</creator><creator>Caimari, Antoni</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Distribution of grape seed flavanols and their metabolites in pregnant rats and their fetuses</title><author>Arola-Arnal, Anna ; Oms-Oliu, Gemma ; Crescenti, Anna ; del Bas, Josep Maria ; Ras, Maria Rosa ; Arola, Lluís ; Caimari, Antoni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4085-f077cd989421583d52ccc5bfdcc084fe5f3b8872b319e98116ea6a24b45727a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Amniotic fluid</topic><topic>Amniotic Fluid - drug effects</topic><topic>Amniotic Fluid - metabolism</topic><topic>Animals</topic><topic>Bioavailability</topic><topic>Biological and medical sciences</topic><topic>Biological Availability</topic><topic>Brain - drug effects</topic><topic>Brain - metabolism</topic><topic>Chromatography, Liquid</topic><topic>Feeding. Feeding behavior</topic><topic>Female</topic><topic>Fetus - drug effects</topic><topic>Fetus - metabolism</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Grape Seed Extract - administration & dosage</topic><topic>Grape Seed Extract - pharmacokinetics</topic><topic>Liver - drug effects</topic><topic>Liver - metabolism</topic><topic>Male</topic><topic>Mass Spectrometry</topic><topic>Placenta</topic><topic>Placenta - drug effects</topic><topic>Placenta - metabolism</topic><topic>Polyphenols</topic><topic>Polyphenols - administration & dosage</topic><topic>Polyphenols - pharmacokinetics</topic><topic>Pregnancy</topic><topic>Proanthocyanidins</topic><topic>Proanthocyanidins - administration & dosage</topic><topic>Proanthocyanidins - pharmacokinetics</topic><topic>Rats</topic><topic>Rats, Wistar</topic><topic>Reproducibility of Results</topic><topic>Seeds - chemistry</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><topic>Vitis - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Arola-Arnal, Anna</creatorcontrib><creatorcontrib>Oms-Oliu, Gemma</creatorcontrib><creatorcontrib>Crescenti, Anna</creatorcontrib><creatorcontrib>del Bas, Josep Maria</creatorcontrib><creatorcontrib>Ras, Maria Rosa</creatorcontrib><creatorcontrib>Arola, Lluís</creatorcontrib><creatorcontrib>Caimari, Antoni</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Molecular nutrition & food research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Arola-Arnal, Anna</au><au>Oms-Oliu, Gemma</au><au>Crescenti, Anna</au><au>del Bas, Josep Maria</au><au>Ras, Maria Rosa</au><au>Arola, Lluís</au><au>Caimari, Antoni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distribution of grape seed flavanols and their metabolites in pregnant rats and their fetuses</atitle><jtitle>Molecular nutrition & food research</jtitle><addtitle>Mol. Nutr. Food Res</addtitle><date>2013-10</date><risdate>2013</risdate><volume>57</volume><issue>10</issue><spage>1741</spage><epage>1752</epage><pages>1741-1752</pages><issn>1613-4125</issn><eissn>1613-4133</eissn><abstract>Scope
Polyphenols have been demonstrated to provide health benefits affecting cellular and physiological processes. This study aims to evaluate the bioavailability and distribution of grape seed flavanol compounds during pregnancy and whether fetuses could be exposed to these compounds.
Methods and results
The distribution of flavanols and their metabolites in rat plasma, liver, white adipose tissue, brain, amniotic fluid, placenta, and fetuses after 1 and 2 h of an acute intake of a grape seed proanthocyanidin extract was examined by LC‐ESI‐TOF/MS. Flavanols and their metabolites were widely distributed in both pregnant and nonpregnant rat plasma and tissues. In liver, the conjugated forms of flavanols were less available in pregnant than nonpregnant rats. Flavanol metabolites were abundant in maternal placenta but detected at low levels in fetuses and amniotic fluid.
Conclusion
Flavanol metabolization appears to be less active in the liver during pregnancy. Moreover, data indicated that transport across the placenta is not efficient and for flavanols and their metabolites, the placenta seems to act as a barrier. However, these compounds target the fetus and are excreted in the amniotic fluid.</abstract><cop>Weinheim</cop><pub>Blackwell Publishing Ltd</pub><pmid>23728968</pmid><doi>10.1002/mnfr.201300032</doi><tpages>12</tpages></addata></record> |
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| ispartof | Molecular nutrition & food research, 2013-10, Vol.57 (10), p.1741-1752 |
| issn | 1613-4125 1613-4133 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Adipose Tissue - drug effects Adipose Tissue - metabolism Amniotic fluid Amniotic Fluid - drug effects Amniotic Fluid - metabolism Animals Bioavailability Biological and medical sciences Biological Availability Brain - drug effects Brain - metabolism Chromatography, Liquid Feeding. Feeding behavior Female Fetus - drug effects Fetus - metabolism Fundamental and applied biological sciences. Psychology Grape Seed Extract - administration & dosage Grape Seed Extract - pharmacokinetics Liver - drug effects Liver - metabolism Male Mass Spectrometry Placenta Placenta - drug effects Placenta - metabolism Polyphenols Polyphenols - administration & dosage Polyphenols - pharmacokinetics Pregnancy Proanthocyanidins Proanthocyanidins - administration & dosage Proanthocyanidins - pharmacokinetics Rats Rats, Wistar Reproducibility of Results Seeds - chemistry Vertebrates: anatomy and physiology, studies on body, several organs or systems Vitis - chemistry |
| title | Distribution of grape seed flavanols and their metabolites in pregnant rats and their fetuses |
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