Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D
Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation reveal...
Gespeichert in:
| Veröffentlicht in: | Chemical & pharmaceutical bulletin 2013, Vol.61 (10), p.1024-1029 |
|---|---|
| Hauptverfasser: | , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 1029 |
|---|---|
| container_issue | 10 |
| container_start_page | 1024 |
| container_title | Chemical & pharmaceutical bulletin |
| container_volume | 61 |
| creator | Kotoku, Naoyuki Mizushima, Kohei Tamura, Satoru Kobayashi, Motomasa |
| description | Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs). |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443413804</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1443413804</sourcerecordid><originalsourceid>FETCH-LOGICAL-p563-7476723698427fd4c30b51f578f0f6a4e9384a861ae589fb464d7b4b3f7144c23</originalsourceid><addsrcrecordid>eNo10EtLxDAUBeAgiDOO_gXJ0k0hzb15dDnM-IIBQWdf0japkb5MUmH-vRXH1YXDd87iXpB1DqgywTmsyHWMn4xxwRRckRVHprUsYE3e3k9D-rDJ1zSmufE20tHRegzJx2SSH-iWmsF0Yztb6sLY00XT3T4LfmiXwLS9HdJv59sn0y9-f0MunemivT3fDTk-Phx3z9nh9elltz1kk5CQKVRScZCFRq5cgzWwSuROKO2YkwZtARqNlrmxQheuQomNqrACp3LEmsOG3P_NTmH8mm1MZe9jbbvODHacY7kowBw0w4Xenelc9bYpp-B7E07l_xvgBwnbVr8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443413804</pqid></control><display><type>article</type><title>Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D</title><source>MEDLINE</source><source>J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Free Full-Text Journals in Chemistry</source><creator>Kotoku, Naoyuki ; Mizushima, Kohei ; Tamura, Satoru ; Kobayashi, Motomasa</creator><creatorcontrib>Kotoku, Naoyuki ; Mizushima, Kohei ; Tamura, Satoru ; Kobayashi, Motomasa</creatorcontrib><description>Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).</description><identifier>EISSN: 1347-5223</identifier><identifier>PMID: 24088693</identifier><language>eng</language><publisher>Japan</publisher><subject>Animals ; Cell Proliferation - drug effects ; Ergocalciferols - chemistry ; Human Umbilical Vein Endothelial Cells ; Humans ; Isomerism ; Molecular Conformation ; Polycyclic Compounds - chemical synthesis ; Polycyclic Compounds - chemistry ; Polycyclic Compounds - pharmacology ; Porifera - chemistry ; Porifera - metabolism</subject><ispartof>Chemical & pharmaceutical bulletin, 2013, Vol.61 (10), p.1024-1029</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,4010</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24088693$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kotoku, Naoyuki</creatorcontrib><creatorcontrib>Mizushima, Kohei</creatorcontrib><creatorcontrib>Tamura, Satoru</creatorcontrib><creatorcontrib>Kobayashi, Motomasa</creatorcontrib><title>Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D</title><title>Chemical & pharmaceutical bulletin</title><addtitle>Chem Pharm Bull (Tokyo)</addtitle><description>Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).</description><subject>Animals</subject><subject>Cell Proliferation - drug effects</subject><subject>Ergocalciferols - chemistry</subject><subject>Human Umbilical Vein Endothelial Cells</subject><subject>Humans</subject><subject>Isomerism</subject><subject>Molecular Conformation</subject><subject>Polycyclic Compounds - chemical synthesis</subject><subject>Polycyclic Compounds - chemistry</subject><subject>Polycyclic Compounds - pharmacology</subject><subject>Porifera - chemistry</subject><subject>Porifera - metabolism</subject><issn>1347-5223</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo10EtLxDAUBeAgiDOO_gXJ0k0hzb15dDnM-IIBQWdf0japkb5MUmH-vRXH1YXDd87iXpB1DqgywTmsyHWMn4xxwRRckRVHprUsYE3e3k9D-rDJ1zSmufE20tHRegzJx2SSH-iWmsF0Yztb6sLY00XT3T4LfmiXwLS9HdJv59sn0y9-f0MunemivT3fDTk-Phx3z9nh9elltz1kk5CQKVRScZCFRq5cgzWwSuROKO2YkwZtARqNlrmxQheuQomNqrACp3LEmsOG3P_NTmH8mm1MZe9jbbvODHacY7kowBw0w4Xenelc9bYpp-B7E07l_xvgBwnbVr8</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Kotoku, Naoyuki</creator><creator>Mizushima, Kohei</creator><creator>Tamura, Satoru</creator><creator>Kobayashi, Motomasa</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>2013</creationdate><title>Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D</title><author>Kotoku, Naoyuki ; Mizushima, Kohei ; Tamura, Satoru ; Kobayashi, Motomasa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p563-7476723698427fd4c30b51f578f0f6a4e9384a861ae589fb464d7b4b3f7144c23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Animals</topic><topic>Cell Proliferation - drug effects</topic><topic>Ergocalciferols - chemistry</topic><topic>Human Umbilical Vein Endothelial Cells</topic><topic>Humans</topic><topic>Isomerism</topic><topic>Molecular Conformation</topic><topic>Polycyclic Compounds - chemical synthesis</topic><topic>Polycyclic Compounds - chemistry</topic><topic>Polycyclic Compounds - pharmacology</topic><topic>Porifera - chemistry</topic><topic>Porifera - metabolism</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kotoku, Naoyuki</creatorcontrib><creatorcontrib>Mizushima, Kohei</creatorcontrib><creatorcontrib>Tamura, Satoru</creatorcontrib><creatorcontrib>Kobayashi, Motomasa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chemical & pharmaceutical bulletin</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kotoku, Naoyuki</au><au>Mizushima, Kohei</au><au>Tamura, Satoru</au><au>Kobayashi, Motomasa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D</atitle><jtitle>Chemical & pharmaceutical bulletin</jtitle><addtitle>Chem Pharm Bull (Tokyo)</addtitle><date>2013</date><risdate>2013</risdate><volume>61</volume><issue>10</issue><spage>1024</spage><epage>1029</epage><pages>1024-1029</pages><eissn>1347-5223</eissn><abstract>Syntheses of analogue compounds of cortistatin A (1), an anti-angiogenic steroidal alkaloid from Indonesian marine sponge, were investigated by utilizing the CD-ring fragment of vitamin D₂. The incidental preparation of a new analogue having CD-cis-fused skeleton and its biological evaluation revealed the importance of the CD-trans-fused structure for the potent and selective antiproliferative activity of 1 against human umbilical vein endothelial cells (HUVECs).</abstract><cop>Japan</cop><pmid>24088693</pmid><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
| identifier | EISSN: 1347-5223 |
| ispartof | Chemical & pharmaceutical bulletin, 2013, Vol.61 (10), p.1024-1029 |
| issn | 1347-5223 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1443413804 |
| source | MEDLINE; J-STAGE (Japan Science & Technology Information Aggregator, Electronic) Freely Available Titles - Japanese; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Free Full-Text Journals in Chemistry |
| subjects | Animals Cell Proliferation - drug effects Ergocalciferols - chemistry Human Umbilical Vein Endothelial Cells Humans Isomerism Molecular Conformation Polycyclic Compounds - chemical synthesis Polycyclic Compounds - chemistry Polycyclic Compounds - pharmacology Porifera - chemistry Porifera - metabolism |
| title | Synthetic studies of cortistatin A analogue from the CD-ring fragment of vitamin D |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-02T05%3A34%3A28IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Synthetic%20studies%20of%20cortistatin%20A%20analogue%20from%20the%20CD-ring%20fragment%20of%20vitamin%20D&rft.jtitle=Chemical%20&%20pharmaceutical%20bulletin&rft.au=Kotoku,%20Naoyuki&rft.date=2013&rft.volume=61&rft.issue=10&rft.spage=1024&rft.epage=1029&rft.pages=1024-1029&rft.eissn=1347-5223&rft_id=info:doi/&rft_dat=%3Cproquest_pubme%3E1443413804%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443413804&rft_id=info:pmid/24088693&rfr_iscdi=true |