Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women
Abstract The serotonin (5-HT) system in the brain plays an important role in mood regulation. The postpartum period is considered a high-risk time for mood and anxiety disorders. We assessed changes in 5-HT levels in whole blood (as an indicator of brain 5-HT concentrations) and mood states before a...
Gespeichert in:
| Veröffentlicht in: | Psychiatry research 2013-10, Vol.209 (3), p.560-565 |
|---|---|
| Hauptverfasser: | , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 565 |
|---|---|
| container_issue | 3 |
| container_start_page | 560 |
| container_title | Psychiatry research |
| container_volume | 209 |
| creator | Sekiyama, Tamami Nakatani, Yasushi Yu, Xinjun Seki, Yoshinari Sato-Suzuki, Ikuko Arita, Hideho |
| description | Abstract The serotonin (5-HT) system in the brain plays an important role in mood regulation. The postpartum period is considered a high-risk time for mood and anxiety disorders. We assessed changes in 5-HT levels in whole blood (as an indicator of brain 5-HT concentrations) and mood states before and after delivery in 28 healthy, lactating postpartum women. Mood states were evaluated using Profile of Mood States questionnaires (POMS). Measurements were done on the same day in early (first week) and late (third–fourth and sixth–seventh weeks) postpartum, and compared with those in the third trimester and in age-matched, healthy, non-pregnant women. Mean 5-HT concentrations were significantly higher and mean tension/anxiety scores of POMS were significantly lower in late (but not early) postpartum than in the third trimester or non-pregnant controls. 5-HT concentrations correlated with tension/anxiety in the third trimester and late postpartum, indicating an important role for the 5-HT system in the regulation of tension/anxiety in healthy postpartum women. The mechanism underlying the changes in the 5-HT system may be rapid inhibition induced by the marked decrease in estradiol after delivery and gradual excitation caused by lactation-induced brain oxytocin release during the postpartum period. |
| doi_str_mv | 10.1016/j.psychres.2013.03.009 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443413661</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0165178113001406</els_id><sourcerecordid>1443413661</sourcerecordid><originalsourceid>FETCH-LOGICAL-c584t-e5e8c7f57210dca56f0df492e437d5104492a02fc9bb5261ce624f063e8f0c4a3</originalsourceid><addsrcrecordid>eNqFkktv1DAQgCMEokvhL1S5IHHJdvyIk1wQqKJQqRIH4Gx5nQnrJbEX22kJv76z2i1IXJBG8kPfzFifpyguGKwZMHW5W-_TYrcR05oDE2uggO5JsWJtw6uGcfG0WBFYV6xp2VnxIqUdAHDWdc-LMy5qSWCzKn7feBvRJOzLzRhCXyaMIQfvfGmDt-hzNNkFn0oTka5ixNFkou9d3pYR-9nSIaNPBF0a_8thXkrK3qIZ83Yp9yHlvYl5nsrR2EzF_PfyPkzoXxbPBjMmfHVaz4tv1x--Xn2qbj9_vLl6f1vZupW5whpb2wx1wxn01tRqgH6QHUcpmr5mIGlvgA-222xqrphFxeUASmA7gJVGnBdvjnX3MfycMWU9uWRxHI3HMCfNpBSSCaUYoeqI2hhSijjofXSTiYtmoA_e9U4_etcH7xoooKPEi1OPeTNh_yftUTQBr0-ASdaMQzTeuvSXa1olGsWJe3fkkIzcOYw6WYf0Eb2LaLPug_v_W97-U8KOzjvq-gMXTLswR0--NdOJa9BfDlNyGBImAJgkcQ_p4LzD</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443413661</pqid></control><display><type>article</type><title>Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals Complete</source><creator>Sekiyama, Tamami ; Nakatani, Yasushi ; Yu, Xinjun ; Seki, Yoshinari ; Sato-Suzuki, Ikuko ; Arita, Hideho</creator><creatorcontrib>Sekiyama, Tamami ; Nakatani, Yasushi ; Yu, Xinjun ; Seki, Yoshinari ; Sato-Suzuki, Ikuko ; Arita, Hideho</creatorcontrib><description>Abstract The serotonin (5-HT) system in the brain plays an important role in mood regulation. The postpartum period is considered a high-risk time for mood and anxiety disorders. We assessed changes in 5-HT levels in whole blood (as an indicator of brain 5-HT concentrations) and mood states before and after delivery in 28 healthy, lactating postpartum women. Mood states were evaluated using Profile of Mood States questionnaires (POMS). Measurements were done on the same day in early (first week) and late (third–fourth and sixth–seventh weeks) postpartum, and compared with those in the third trimester and in age-matched, healthy, non-pregnant women. Mean 5-HT concentrations were significantly higher and mean tension/anxiety scores of POMS were significantly lower in late (but not early) postpartum than in the third trimester or non-pregnant controls. 5-HT concentrations correlated with tension/anxiety in the third trimester and late postpartum, indicating an important role for the 5-HT system in the regulation of tension/anxiety in healthy postpartum women. The mechanism underlying the changes in the 5-HT system may be rapid inhibition induced by the marked decrease in estradiol after delivery and gradual excitation caused by lactation-induced brain oxytocin release during the postpartum period.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2013.03.009</identifier><identifier>PMID: 23541877</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>Adult ; Affectivity. Emotion ; Anxiety - blood ; Biological and medical sciences ; Chromatography, High Pressure Liquid ; Electrochemistry ; Estradiol ; Estradiol - blood ; Female ; Fundamental and applied biological sciences. Psychology ; Gynecology and obstetrics ; Humans ; Lactation - psychology ; Mood ; Oxytocin ; Oxytocin - blood ; Personality. Affectivity ; Pregnancy ; Psychiatric Status Rating Scales ; Psychiatry ; Psychological Tests ; Psychology and medicine ; Psychology. Psychoanalysis. Psychiatry ; Psychology. Psychophysiology ; Serotonin - blood ; Statistics, Nonparametric ; Surveys and Questionnaires ; Young Adult</subject><ispartof>Psychiatry research, 2013-10, Vol.209 (3), p.560-565</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c584t-e5e8c7f57210dca56f0df492e437d5104492a02fc9bb5261ce624f063e8f0c4a3</citedby><cites>FETCH-LOGICAL-c584t-e5e8c7f57210dca56f0df492e437d5104492a02fc9bb5261ce624f063e8f0c4a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165178113001406$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65534</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27863762$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23541877$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sekiyama, Tamami</creatorcontrib><creatorcontrib>Nakatani, Yasushi</creatorcontrib><creatorcontrib>Yu, Xinjun</creatorcontrib><creatorcontrib>Seki, Yoshinari</creatorcontrib><creatorcontrib>Sato-Suzuki, Ikuko</creatorcontrib><creatorcontrib>Arita, Hideho</creatorcontrib><title>Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract The serotonin (5-HT) system in the brain plays an important role in mood regulation. The postpartum period is considered a high-risk time for mood and anxiety disorders. We assessed changes in 5-HT levels in whole blood (as an indicator of brain 5-HT concentrations) and mood states before and after delivery in 28 healthy, lactating postpartum women. Mood states were evaluated using Profile of Mood States questionnaires (POMS). Measurements were done on the same day in early (first week) and late (third–fourth and sixth–seventh weeks) postpartum, and compared with those in the third trimester and in age-matched, healthy, non-pregnant women. Mean 5-HT concentrations were significantly higher and mean tension/anxiety scores of POMS were significantly lower in late (but not early) postpartum than in the third trimester or non-pregnant controls. 5-HT concentrations correlated with tension/anxiety in the third trimester and late postpartum, indicating an important role for the 5-HT system in the regulation of tension/anxiety in healthy postpartum women. The mechanism underlying the changes in the 5-HT system may be rapid inhibition induced by the marked decrease in estradiol after delivery and gradual excitation caused by lactation-induced brain oxytocin release during the postpartum period.</description><subject>Adult</subject><subject>Affectivity. Emotion</subject><subject>Anxiety - blood</subject><subject>Biological and medical sciences</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Electrochemistry</subject><subject>Estradiol</subject><subject>Estradiol - blood</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gynecology and obstetrics</subject><subject>Humans</subject><subject>Lactation - psychology</subject><subject>Mood</subject><subject>Oxytocin</subject><subject>Oxytocin - blood</subject><subject>Personality. Affectivity</subject><subject>Pregnancy</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychiatry</subject><subject>Psychological Tests</subject><subject>Psychology and medicine</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychology. Psychophysiology</subject><subject>Serotonin - blood</subject><subject>Statistics, Nonparametric</subject><subject>Surveys and Questionnaires</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkktv1DAQgCMEokvhL1S5IHHJdvyIk1wQqKJQqRIH4Gx5nQnrJbEX22kJv76z2i1IXJBG8kPfzFifpyguGKwZMHW5W-_TYrcR05oDE2uggO5JsWJtw6uGcfG0WBFYV6xp2VnxIqUdAHDWdc-LMy5qSWCzKn7feBvRJOzLzRhCXyaMIQfvfGmDt-hzNNkFn0oTka5ixNFkou9d3pYR-9nSIaNPBF0a_8thXkrK3qIZ83Yp9yHlvYl5nsrR2EzF_PfyPkzoXxbPBjMmfHVaz4tv1x--Xn2qbj9_vLl6f1vZupW5whpb2wx1wxn01tRqgH6QHUcpmr5mIGlvgA-222xqrphFxeUASmA7gJVGnBdvjnX3MfycMWU9uWRxHI3HMCfNpBSSCaUYoeqI2hhSijjofXSTiYtmoA_e9U4_etcH7xoooKPEi1OPeTNh_yftUTQBr0-ASdaMQzTeuvSXa1olGsWJe3fkkIzcOYw6WYf0Eb2LaLPug_v_W97-U8KOzjvq-gMXTLswR0--NdOJa9BfDlNyGBImAJgkcQ_p4LzD</recordid><startdate>20131030</startdate><enddate>20131030</enddate><creator>Sekiyama, Tamami</creator><creator>Nakatani, Yasushi</creator><creator>Yu, Xinjun</creator><creator>Seki, Yoshinari</creator><creator>Sato-Suzuki, Ikuko</creator><creator>Arita, Hideho</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131030</creationdate><title>Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women</title><author>Sekiyama, Tamami ; Nakatani, Yasushi ; Yu, Xinjun ; Seki, Yoshinari ; Sato-Suzuki, Ikuko ; Arita, Hideho</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c584t-e5e8c7f57210dca56f0df492e437d5104492a02fc9bb5261ce624f063e8f0c4a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Affectivity. Emotion</topic><topic>Anxiety - blood</topic><topic>Biological and medical sciences</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Electrochemistry</topic><topic>Estradiol</topic><topic>Estradiol - blood</topic><topic>Female</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gynecology and obstetrics</topic><topic>Humans</topic><topic>Lactation - psychology</topic><topic>Mood</topic><topic>Oxytocin</topic><topic>Oxytocin - blood</topic><topic>Personality. Affectivity</topic><topic>Pregnancy</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychiatry</topic><topic>Psychological Tests</topic><topic>Psychology and medicine</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychology. Psychophysiology</topic><topic>Serotonin - blood</topic><topic>Statistics, Nonparametric</topic><topic>Surveys and Questionnaires</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sekiyama, Tamami</creatorcontrib><creatorcontrib>Nakatani, Yasushi</creatorcontrib><creatorcontrib>Yu, Xinjun</creatorcontrib><creatorcontrib>Seki, Yoshinari</creatorcontrib><creatorcontrib>Sato-Suzuki, Ikuko</creatorcontrib><creatorcontrib>Arita, Hideho</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sekiyama, Tamami</au><au>Nakatani, Yasushi</au><au>Yu, Xinjun</au><au>Seki, Yoshinari</au><au>Sato-Suzuki, Ikuko</au><au>Arita, Hideho</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-10-30</date><risdate>2013</risdate><volume>209</volume><issue>3</issue><spage>560</spage><epage>565</epage><pages>560-565</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract The serotonin (5-HT) system in the brain plays an important role in mood regulation. The postpartum period is considered a high-risk time for mood and anxiety disorders. We assessed changes in 5-HT levels in whole blood (as an indicator of brain 5-HT concentrations) and mood states before and after delivery in 28 healthy, lactating postpartum women. Mood states were evaluated using Profile of Mood States questionnaires (POMS). Measurements were done on the same day in early (first week) and late (third–fourth and sixth–seventh weeks) postpartum, and compared with those in the third trimester and in age-matched, healthy, non-pregnant women. Mean 5-HT concentrations were significantly higher and mean tension/anxiety scores of POMS were significantly lower in late (but not early) postpartum than in the third trimester or non-pregnant controls. 5-HT concentrations correlated with tension/anxiety in the third trimester and late postpartum, indicating an important role for the 5-HT system in the regulation of tension/anxiety in healthy postpartum women. The mechanism underlying the changes in the 5-HT system may be rapid inhibition induced by the marked decrease in estradiol after delivery and gradual excitation caused by lactation-induced brain oxytocin release during the postpartum period.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>23541877</pmid><doi>10.1016/j.psychres.2013.03.009</doi><tpages>6</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0165-1781 |
| ispartof | Psychiatry research, 2013-10, Vol.209 (3), p.560-565 |
| issn | 0165-1781 1872-7123 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1443413661 |
| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Adult Affectivity. Emotion Anxiety - blood Biological and medical sciences Chromatography, High Pressure Liquid Electrochemistry Estradiol Estradiol - blood Female Fundamental and applied biological sciences. Psychology Gynecology and obstetrics Humans Lactation - psychology Mood Oxytocin Oxytocin - blood Personality. Affectivity Pregnancy Psychiatric Status Rating Scales Psychiatry Psychological Tests Psychology and medicine Psychology. Psychoanalysis. Psychiatry Psychology. Psychophysiology Serotonin - blood Statistics, Nonparametric Surveys and Questionnaires Young Adult |
| title | Increased blood serotonin concentrations are correlated with reduced tension/anxiety in healthy postpartum lactating women |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T17%3A57%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Increased%20blood%20serotonin%20concentrations%20are%20correlated%20with%20reduced%20tension/anxiety%20in%20healthy%20postpartum%20lactating%20women&rft.jtitle=Psychiatry%20research&rft.au=Sekiyama,%20Tamami&rft.date=2013-10-30&rft.volume=209&rft.issue=3&rft.spage=560&rft.epage=565&rft.pages=560-565&rft.issn=0165-1781&rft.eissn=1872-7123&rft.coden=PSRSDR&rft_id=info:doi/10.1016/j.psychres.2013.03.009&rft_dat=%3Cproquest_cross%3E1443413661%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443413661&rft_id=info:pmid/23541877&rft_els_id=S0165178113001406&rfr_iscdi=true |