Effect of PEGylation on Controllably Spaced Adsorption of Ferritin Molecules
The interparticle distance between nanoparticles (NPs) dispersed on on SiO2 was shown to be controlled by PEGylation. Ferritins with nanoparticle cores were prepared and PEGylated with poly(ethylene glycol)s (PEGs) of two different molecular weights. It was shown that the thickness of the PEG layer...
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| Veröffentlicht in: | Langmuir 2013-10, Vol.29 (41), p.12737-12743 |
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| container_title | Langmuir |
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| creator | Tsukamoto, Rikako Godonoga, Maia Matsuyama, Ryota Igarashi, Makoto Heddle, Jonathan Gardiner Samukawa, Seiji Yamashita, Ichiro |
| description | The interparticle distance between nanoparticles (NPs) dispersed on on SiO2 was shown to be controlled by PEGylation. Ferritins with nanoparticle cores were prepared and PEGylated with poly(ethylene glycol)s (PEGs) of two different molecular weights. It was shown that the thickness of the PEG layer on the ferritin surface determines the interparticle distance under short Debye lengths. Under conditions where the Debye length was greater than the PEG layer thickness, distance between ferritins increased due to the electrostatic repulsive force. Results suggest that the PEG layer accommodated a small amount of counterions insufficient to cancel the ferritin outer surface charges. Simulation showed that ferritins adsorbed randomly and interparticle distance can be predicted theoretically. We demonstrate that PEGylated ferritins, that is, NP cores, can be dispersed on a surface with interval distances between particles determined by the combination of the ionic strength of the solution and the molecular weight of the PEG. |
| doi_str_mv | 10.1021/la4029595 |
| format | Article |
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Ferritins with nanoparticle cores were prepared and PEGylated with poly(ethylene glycol)s (PEGs) of two different molecular weights. It was shown that the thickness of the PEG layer on the ferritin surface determines the interparticle distance under short Debye lengths. Under conditions where the Debye length was greater than the PEG layer thickness, distance between ferritins increased due to the electrostatic repulsive force. Results suggest that the PEG layer accommodated a small amount of counterions insufficient to cancel the ferritin outer surface charges. Simulation showed that ferritins adsorbed randomly and interparticle distance can be predicted theoretically. 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Ferritins with nanoparticle cores were prepared and PEGylated with poly(ethylene glycol)s (PEGs) of two different molecular weights. It was shown that the thickness of the PEG layer on the ferritin surface determines the interparticle distance under short Debye lengths. Under conditions where the Debye length was greater than the PEG layer thickness, distance between ferritins increased due to the electrostatic repulsive force. Results suggest that the PEG layer accommodated a small amount of counterions insufficient to cancel the ferritin outer surface charges. Simulation showed that ferritins adsorbed randomly and interparticle distance can be predicted theoretically. We demonstrate that PEGylated ferritins, that is, NP cores, can be dispersed on a surface with interval distances between particles determined by the combination of the ionic strength of the solution and the molecular weight of the PEG.</description><subject>Adsorption</subject><subject>Chemistry</subject><subject>Exact sciences and technology</subject><subject>Ferritins - chemistry</subject><subject>General and physical chemistry</subject><subject>Molecular Weight</subject><subject>Particle Size</subject><subject>Polyglycolic Acid - chemistry</subject><subject>Silicon Dioxide - chemistry</subject><subject>Static Electricity</subject><subject>Surface physical chemistry</subject><subject>Surface Properties</subject><issn>0743-7463</issn><issn>1520-5827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpt0MFKAzEQBuAgiq3Vgy8gexH0sJpskmZzLKWtQkVBPS_TaQJb0k1Ndg99e1Na24swZA75mBl-Qm4ZfWK0YM8OBC201PKM9JksaC7LQp2TPlWC50oMeY9cxbiilGou9CXpFYIKVkjRJ_OJtQbbzNvsYzLbOmhr32Spxr5pg3cOFm6bfW4AzTIbLaMPm72w2dSEULd1k715Z7BzJl6TCwsumptDH5Dv6eRr_JLP32ev49E8B8FYm6PgzHIUQNP1CsqhtgxQ2lKm14DWSAvcfVAEwUGrkqFBWS7UQuqlZnxAHvZzN8H_dCa21bqOaNKxjfFdrJgQPG1SnCf6uKcYfIzB2GoT6jWEbcVotQuvOoaX7N1hbLdYm-VR_qWVwP0BQERwNkCDdTw5VfKh4uXJAcZq5bvQpDT-WfgLJbKBRA</recordid><startdate>20131015</startdate><enddate>20131015</enddate><creator>Tsukamoto, Rikako</creator><creator>Godonoga, Maia</creator><creator>Matsuyama, Ryota</creator><creator>Igarashi, Makoto</creator><creator>Heddle, Jonathan Gardiner</creator><creator>Samukawa, Seiji</creator><creator>Yamashita, Ichiro</creator><general>American Chemical Society</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131015</creationdate><title>Effect of PEGylation on Controllably Spaced Adsorption of Ferritin Molecules</title><author>Tsukamoto, Rikako ; Godonoga, Maia ; Matsuyama, Ryota ; Igarashi, Makoto ; Heddle, Jonathan Gardiner ; Samukawa, Seiji ; Yamashita, Ichiro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a411t-c431f3c4a01027a869f1ac5f85ac5ea99c02c27a80ca43a9781cec58b7b59d913</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adsorption</topic><topic>Chemistry</topic><topic>Exact sciences and technology</topic><topic>Ferritins - chemistry</topic><topic>General and physical chemistry</topic><topic>Molecular Weight</topic><topic>Particle Size</topic><topic>Polyglycolic Acid - chemistry</topic><topic>Silicon Dioxide - chemistry</topic><topic>Static Electricity</topic><topic>Surface physical chemistry</topic><topic>Surface Properties</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tsukamoto, Rikako</creatorcontrib><creatorcontrib>Godonoga, Maia</creatorcontrib><creatorcontrib>Matsuyama, Ryota</creatorcontrib><creatorcontrib>Igarashi, Makoto</creatorcontrib><creatorcontrib>Heddle, Jonathan Gardiner</creatorcontrib><creatorcontrib>Samukawa, Seiji</creatorcontrib><creatorcontrib>Yamashita, Ichiro</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Langmuir</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tsukamoto, Rikako</au><au>Godonoga, Maia</au><au>Matsuyama, Ryota</au><au>Igarashi, Makoto</au><au>Heddle, Jonathan Gardiner</au><au>Samukawa, Seiji</au><au>Yamashita, Ichiro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effect of PEGylation on Controllably Spaced Adsorption of Ferritin Molecules</atitle><jtitle>Langmuir</jtitle><addtitle>Langmuir</addtitle><date>2013-10-15</date><risdate>2013</risdate><volume>29</volume><issue>41</issue><spage>12737</spage><epage>12743</epage><pages>12737-12743</pages><issn>0743-7463</issn><eissn>1520-5827</eissn><coden>LANGD5</coden><abstract>The interparticle distance between nanoparticles (NPs) dispersed on on SiO2 was shown to be controlled by PEGylation. Ferritins with nanoparticle cores were prepared and PEGylated with poly(ethylene glycol)s (PEGs) of two different molecular weights. It was shown that the thickness of the PEG layer on the ferritin surface determines the interparticle distance under short Debye lengths. Under conditions where the Debye length was greater than the PEG layer thickness, distance between ferritins increased due to the electrostatic repulsive force. Results suggest that the PEG layer accommodated a small amount of counterions insufficient to cancel the ferritin outer surface charges. Simulation showed that ferritins adsorbed randomly and interparticle distance can be predicted theoretically. We demonstrate that PEGylated ferritins, that is, NP cores, can be dispersed on a surface with interval distances between particles determined by the combination of the ionic strength of the solution and the molecular weight of the PEG.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>24041254</pmid><doi>10.1021/la4029595</doi><tpages>7</tpages></addata></record> |
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| subjects | Adsorption Chemistry Exact sciences and technology Ferritins - chemistry General and physical chemistry Molecular Weight Particle Size Polyglycolic Acid - chemistry Silicon Dioxide - chemistry Static Electricity Surface physical chemistry Surface Properties |
| title | Effect of PEGylation on Controllably Spaced Adsorption of Ferritin Molecules |
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