Increased systemic oxidatively generated DNA and RNA damage in schizophrenia
Abstract Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical dis...
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| Veröffentlicht in: | Psychiatry research 2013-10, Vol.209 (3), p.417-423 |
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| creator | Jorgensen, Anders Broedbaek, Kasper Fink-Jensen, Anders Knorr, Ulla Greisen Soendergaard, Mia Henriksen, Trine Weimann, Allan Jepsen, Peter Lykkesfeldt, Jens Enghusen Poulsen, Henrik Balslev Jorgensen, Martin |
| description | Abstract Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex-matched controls, using ultra-performance liquid chromatography with tandem mass spectrometry. Measures of psychopathology, perceived stress and cortisol secretion were collected. Patients were re-examined after four months. We found a 20% increase in the median excretion of both markers in schizophrenia patients vs. healthy controls ( P =0.003 and |
| doi_str_mv | 10.1016/j.psychres.2013.01.033 |
| format | Article |
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Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex-matched controls, using ultra-performance liquid chromatography with tandem mass spectrometry. Measures of psychopathology, perceived stress and cortisol secretion were collected. Patients were re-examined after four months. We found a 20% increase in the median excretion of both markers in schizophrenia patients vs. healthy controls ( P =0.003 and <0.001, respectively). This difference persisted after the adjustment for multiple demographical, lifestyle and metabolic factors. In patients, the marker excretion was not influenced by medication load, and was not driven by symptom severity, perceived stress or cortisol secretion, neither at baseline nor in relation to changes at follow-up. We conclude that schizophrenia is associated with increased systemic nucleic acid damage from oxidation, which could constitute a molecular link between schizophrenia and its associated signs of accelerated aging.</description><identifier>ISSN: 0165-1781</identifier><identifier>EISSN: 1872-7123</identifier><identifier>DOI: 10.1016/j.psychres.2013.01.033</identifier><identifier>PMID: 23465294</identifier><identifier>CODEN: PSRSDR</identifier><language>eng</language><publisher>Kidlington: Elsevier Ireland Ltd</publisher><subject>8-oxodG ; 8-oxoGuo ; Adult ; Adult and adolescent clinical studies ; Biological and medical sciences ; Case-Control Studies ; Cortisol ; Deoxyguanosine - metabolism ; DNA Damage - physiology ; Female ; Guanosine - analogs & derivatives ; Guanosine - urine ; Humans ; Hydrocortisone - metabolism ; Male ; Malondialdehyde - blood ; Medical sciences ; Oxidation-Reduction ; Oxidative stress ; Oxidative Stress - physiology ; Perceived stress ; Psychiatry ; Psychology. Psychoanalysis. Psychiatry ; Psychopathology. Psychiatry ; Psychoses ; Retrospective Studies ; RNA - metabolism ; Saliva - metabolism ; Schizophrenia ; Schizophrenia - blood ; Schizophrenia - physiopathology ; Schizophrenia - urine ; Young Adult</subject><ispartof>Psychiatry research, 2013-10, Vol.209 (3), p.417-423</ispartof><rights>Elsevier Ireland Ltd</rights><rights>2013 Elsevier Ireland Ltd</rights><rights>2015 INIST-CNRS</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-58e1676008f7c7714e702cd0ac1d1f753efa005a283f13afc4a05b6d203228983</citedby><cites>FETCH-LOGICAL-c453t-58e1676008f7c7714e702cd0ac1d1f753efa005a283f13afc4a05b6d203228983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0165178113000553$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27863740$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23465294$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jorgensen, Anders</creatorcontrib><creatorcontrib>Broedbaek, Kasper</creatorcontrib><creatorcontrib>Fink-Jensen, Anders</creatorcontrib><creatorcontrib>Knorr, Ulla</creatorcontrib><creatorcontrib>Greisen Soendergaard, Mia</creatorcontrib><creatorcontrib>Henriksen, Trine</creatorcontrib><creatorcontrib>Weimann, Allan</creatorcontrib><creatorcontrib>Jepsen, Peter</creatorcontrib><creatorcontrib>Lykkesfeldt, Jens</creatorcontrib><creatorcontrib>Enghusen Poulsen, Henrik</creatorcontrib><creatorcontrib>Balslev Jorgensen, Martin</creatorcontrib><title>Increased systemic oxidatively generated DNA and RNA damage in schizophrenia</title><title>Psychiatry research</title><addtitle>Psychiatry Res</addtitle><description>Abstract Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex-matched controls, using ultra-performance liquid chromatography with tandem mass spectrometry. Measures of psychopathology, perceived stress and cortisol secretion were collected. Patients were re-examined after four months. We found a 20% increase in the median excretion of both markers in schizophrenia patients vs. healthy controls ( P =0.003 and <0.001, respectively). This difference persisted after the adjustment for multiple demographical, lifestyle and metabolic factors. In patients, the marker excretion was not influenced by medication load, and was not driven by symptom severity, perceived stress or cortisol secretion, neither at baseline nor in relation to changes at follow-up. We conclude that schizophrenia is associated with increased systemic nucleic acid damage from oxidation, which could constitute a molecular link between schizophrenia and its associated signs of accelerated aging.</description><subject>8-oxodG</subject><subject>8-oxoGuo</subject><subject>Adult</subject><subject>Adult and adolescent clinical studies</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Cortisol</subject><subject>Deoxyguanosine - metabolism</subject><subject>DNA Damage - physiology</subject><subject>Female</subject><subject>Guanosine - analogs & derivatives</subject><subject>Guanosine - urine</subject><subject>Humans</subject><subject>Hydrocortisone - metabolism</subject><subject>Male</subject><subject>Malondialdehyde - blood</subject><subject>Medical sciences</subject><subject>Oxidation-Reduction</subject><subject>Oxidative stress</subject><subject>Oxidative Stress - physiology</subject><subject>Perceived stress</subject><subject>Psychiatry</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopathology. Psychiatry</subject><subject>Psychoses</subject><subject>Retrospective Studies</subject><subject>RNA - metabolism</subject><subject>Saliva - metabolism</subject><subject>Schizophrenia</subject><subject>Schizophrenia - blood</subject><subject>Schizophrenia - physiopathology</subject><subject>Schizophrenia - urine</subject><subject>Young Adult</subject><issn>0165-1781</issn><issn>1872-7123</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkU1v1DAQhi0EotvCX6hyQeKSMGMncfaCqAqUSiuQ-Dhbrj1pvWSdxZOtCL8er3YLEhdOc5hnPvS8QpwjVAjYvlpXW57dXSKuJKCqACtQ6pFYYKdlqVGqx2KRwaZE3eGJOGVeA4DE5fKpOJGqbhu5rBdidR1dIsvkC555ok1wxfgzeDuFexrm4pYiJTvl9tuPF4WNvvicq7cbe0tFiAW7u_Br3OZHYrDPxJPeDkzPj_VMfHv_7uvlh3L16er68mJVurpRU9l0hK1uAbpeO62xJg3SebAOPfa6UdRbgMbKTvWobO9qC81N6yUoKbtlp87Ey8PebRp_7IgnswnsaBhspHHHButa1aCVbDPaHlCXRuZEvdmmsLFpNghmb9KszYNJszdpAE02mQfPjzd2Nxvyf8Ye1GXgxRGw7OzQJxtd4L-c7lqla8jcmwNH2ch9oGTYBYqOfEjkJuPH8P9fXv-zwg0hhnz1O83E63GXYvZt0LA0YL7sc9_HjipH3jRK_QYSu6jC</recordid><startdate>20131030</startdate><enddate>20131030</enddate><creator>Jorgensen, Anders</creator><creator>Broedbaek, Kasper</creator><creator>Fink-Jensen, Anders</creator><creator>Knorr, Ulla</creator><creator>Greisen Soendergaard, Mia</creator><creator>Henriksen, Trine</creator><creator>Weimann, Allan</creator><creator>Jepsen, Peter</creator><creator>Lykkesfeldt, Jens</creator><creator>Enghusen Poulsen, Henrik</creator><creator>Balslev Jorgensen, Martin</creator><general>Elsevier Ireland Ltd</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131030</creationdate><title>Increased systemic oxidatively generated DNA and RNA damage in schizophrenia</title><author>Jorgensen, Anders ; Broedbaek, Kasper ; Fink-Jensen, Anders ; Knorr, Ulla ; Greisen Soendergaard, Mia ; Henriksen, Trine ; Weimann, Allan ; Jepsen, Peter ; Lykkesfeldt, Jens ; Enghusen Poulsen, Henrik ; Balslev Jorgensen, Martin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-58e1676008f7c7714e702cd0ac1d1f753efa005a283f13afc4a05b6d203228983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>8-oxodG</topic><topic>8-oxoGuo</topic><topic>Adult</topic><topic>Adult and adolescent clinical studies</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Cortisol</topic><topic>Deoxyguanosine - metabolism</topic><topic>DNA Damage - physiology</topic><topic>Female</topic><topic>Guanosine - analogs & derivatives</topic><topic>Guanosine - urine</topic><topic>Humans</topic><topic>Hydrocortisone - metabolism</topic><topic>Male</topic><topic>Malondialdehyde - blood</topic><topic>Medical sciences</topic><topic>Oxidation-Reduction</topic><topic>Oxidative stress</topic><topic>Oxidative Stress - physiology</topic><topic>Perceived stress</topic><topic>Psychiatry</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychopathology. Psychiatry</topic><topic>Psychoses</topic><topic>Retrospective Studies</topic><topic>RNA - metabolism</topic><topic>Saliva - metabolism</topic><topic>Schizophrenia</topic><topic>Schizophrenia - blood</topic><topic>Schizophrenia - physiopathology</topic><topic>Schizophrenia - urine</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jorgensen, Anders</creatorcontrib><creatorcontrib>Broedbaek, Kasper</creatorcontrib><creatorcontrib>Fink-Jensen, Anders</creatorcontrib><creatorcontrib>Knorr, Ulla</creatorcontrib><creatorcontrib>Greisen Soendergaard, Mia</creatorcontrib><creatorcontrib>Henriksen, Trine</creatorcontrib><creatorcontrib>Weimann, Allan</creatorcontrib><creatorcontrib>Jepsen, Peter</creatorcontrib><creatorcontrib>Lykkesfeldt, Jens</creatorcontrib><creatorcontrib>Enghusen Poulsen, Henrik</creatorcontrib><creatorcontrib>Balslev Jorgensen, Martin</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Psychiatry research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jorgensen, Anders</au><au>Broedbaek, Kasper</au><au>Fink-Jensen, Anders</au><au>Knorr, Ulla</au><au>Greisen Soendergaard, Mia</au><au>Henriksen, Trine</au><au>Weimann, Allan</au><au>Jepsen, Peter</au><au>Lykkesfeldt, Jens</au><au>Enghusen Poulsen, Henrik</au><au>Balslev Jorgensen, Martin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Increased systemic oxidatively generated DNA and RNA damage in schizophrenia</atitle><jtitle>Psychiatry research</jtitle><addtitle>Psychiatry Res</addtitle><date>2013-10-30</date><risdate>2013</risdate><volume>209</volume><issue>3</issue><spage>417</spage><epage>423</epage><pages>417-423</pages><issn>0165-1781</issn><eissn>1872-7123</eissn><coden>PSRSDR</coden><abstract>Abstract Schizophrenia is associated with a substantially increased somatic morbidity and mortality, which may partly be caused by accelerated cellular aging. Oxidative stress is an established mediator of aging and a suggested aetiological mechanism in both schizophrenia and age-related medical disorders such as cardiovascular disease, type 2 diabetes and dementia. We determined the urinary excretion of markers of systemic Deoxyribonucleic Acid (DNA) and Ribonucleic Acid (RNA) oxidation, 8-oxo-7,8-dihydro-2′-deoxyguanosine and 8-oxo-7,8-dihydroguanosine, respectively, in 40 schizophrenia patients and 40 age- and sex-matched controls, using ultra-performance liquid chromatography with tandem mass spectrometry. Measures of psychopathology, perceived stress and cortisol secretion were collected. Patients were re-examined after four months. We found a 20% increase in the median excretion of both markers in schizophrenia patients vs. healthy controls ( P =0.003 and <0.001, respectively). This difference persisted after the adjustment for multiple demographical, lifestyle and metabolic factors. In patients, the marker excretion was not influenced by medication load, and was not driven by symptom severity, perceived stress or cortisol secretion, neither at baseline nor in relation to changes at follow-up. We conclude that schizophrenia is associated with increased systemic nucleic acid damage from oxidation, which could constitute a molecular link between schizophrenia and its associated signs of accelerated aging.</abstract><cop>Kidlington</cop><pub>Elsevier Ireland Ltd</pub><pmid>23465294</pmid><doi>10.1016/j.psychres.2013.01.033</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 8-oxodG 8-oxoGuo Adult Adult and adolescent clinical studies Biological and medical sciences Case-Control Studies Cortisol Deoxyguanosine - metabolism DNA Damage - physiology Female Guanosine - analogs & derivatives Guanosine - urine Humans Hydrocortisone - metabolism Male Malondialdehyde - blood Medical sciences Oxidation-Reduction Oxidative stress Oxidative Stress - physiology Perceived stress Psychiatry Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Psychoses Retrospective Studies RNA - metabolism Saliva - metabolism Schizophrenia Schizophrenia - blood Schizophrenia - physiopathology Schizophrenia - urine Young Adult |
| title | Increased systemic oxidatively generated DNA and RNA damage in schizophrenia |
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