Benzylidene 2-Aminoimidazolones Derivatives: Synthesis and in Vitro Evaluation of Anti-tumor Carcinoma Activity

A series of benzylidene 2-aminoimidazolones derivatives were synthesized. Most compounds displayed strong inhibitory activity on the proliferation of human HepG2 cells in vitro. The active compounds were further evaluated by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay ag...

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Veröffentlicht in:	Chemical & pharmaceutical bulletin 2013/10/01, Vol.61(10), pp.1081-1084
Hauptverfasser:	Ling, Yong, Wang, Zhi-Qiang, Xiao, You-An, Zhu, Chenyu, Shen, Liucen, Wang, Xue-Min, Hui, Yi, Wang, Xin-Yang
Format:	Artikel
Sprache:	eng
Schlagworte:	2-aminoimidazolone derivative anti-tumor agent Antineoplastic Agents - chemical synthesis Antineoplastic Agents - chemistry Antineoplastic Agents - toxicity Apoptosis - drug effects Benzylidene Compounds - chemistry cell apoptosis Cell Line, Tumor Cell Proliferation - drug effects Drug Screening Assays, Antitumor Hep G2 Cells Humans Imidazoles - chemical synthesis Imidazoles - chemistry Imidazoles - toxicity inhibitory activity Structure-Activity Relationship synthesis
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