Management of Portal Hypertension in Children With Portal Vein Thrombosis
ABSTRACT Portal vein thrombosis (PVT) is a common cause of portal hypertension in children. Predisposing conditions for PVT are obscure in more than half of the cases. Variceal bleeding and splenomegaly are the most frequent initial manifestations. Radiologic imaging studies are the mainstay for dia...
Gespeichert in:
| Veröffentlicht in: | Journal of pediatric gastroenterology and nutrition 2013-10, Vol.57 (4), p.419-425 |
|---|---|
| Hauptverfasser: | , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 425 |
|---|---|
| container_issue | 4 |
| container_start_page | 419 |
| container_title | Journal of pediatric gastroenterology and nutrition |
| container_volume | 57 |
| creator | Giouleme, Olga Theocharidou, Eleni |
| description | ABSTRACT
Portal vein thrombosis (PVT) is a common cause of portal hypertension in children. Predisposing conditions for PVT are obscure in more than half of the cases. Variceal bleeding and splenomegaly are the most frequent initial manifestations. Radiologic imaging studies are the mainstay for diagnosis. Treatment includes pharmacologic, endoscopic, and surgical modalities. β‐Adrenergic blockers are not routinely used in children because of unproven efficacy and significant adverse effects. Endoscopic methods, such as sclerotherapy and endoscopic variceal ligation (EVL), are highly effective in the treatment of acute variceal bleeding and eradication of varices. EVL is the treatment of choice because of minimal complications and the need for few endoscopic sessions. EVL facilitates portal decompression either by the formation of collateral vessels or by surgical portosystemic shunting, when vessels grow to the proper diameter for anastomosis. Surgical portosystemic shunts are reserved for refractory cases because of significant complications and technical difficulties. Transjugular portosystemic shunts have an emerging role in the management of portal hypertension caused by PVT. PVT may occur in the posttransplant setting, but optimal management is not defined yet. |
| doi_str_mv | 10.1097/MPG.0b013e3182a1cd7f |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443406025</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1443406025</sourcerecordid><originalsourceid>FETCH-LOGICAL-c486f-5c68da03d7bc33992772964469ce200699e0aed5411204c1d9e171f5eac0860d3</originalsourceid><addsrcrecordid>eNqNkE1v1DAQhi0EokvhHyCUCxKXlPFH_HHgACv6pRb2UOBoeZ0JMTjxYmdV7b8n1W6LxAVOc5jnnXn0EvKSwgkFo95er85OYA2UI6eaOepb1T0iC9pwWQsN9DFZAFOqZpTKI_KslB8AoEQDT8kR45qBAFiQi2s3uu844DhVqatWKU8uVue7DeYJxxLSWIWxWvYhthnH6luY-nvoK86bmz6nYZ1KKM_Jk87Fgi8O85h8Of14szyvrz6fXSzfX9VeaNnVjZe6dcBbtfacGzMrMiOFkMYjA5DGIDhsG0HprOhpa5Aq2jXoPGgJLT8mb_Z3Nzn92mKZ7BCKxxjdiGlbLBWCC5DAmhkVe9TnVErGzm5yGFzeWQr2rkQ7l2j_LnGOvTp82K4HbB9C963NwOsD4Ip3sctu9KH84ZTSBvgdp_fcbYoT5vIzbm8x2x5dnPp_Obw7REPE3X9528vVJ_7hFKRkmv8GFTqfYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443406025</pqid></control><display><type>article</type><title>Management of Portal Hypertension in Children With Portal Vein Thrombosis</title><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><source>Journals@Ovid Complete</source><creator>Giouleme, Olga ; Theocharidou, Eleni</creator><creatorcontrib>Giouleme, Olga ; Theocharidou, Eleni</creatorcontrib><description>ABSTRACT
Portal vein thrombosis (PVT) is a common cause of portal hypertension in children. Predisposing conditions for PVT are obscure in more than half of the cases. Variceal bleeding and splenomegaly are the most frequent initial manifestations. Radiologic imaging studies are the mainstay for diagnosis. Treatment includes pharmacologic, endoscopic, and surgical modalities. β‐Adrenergic blockers are not routinely used in children because of unproven efficacy and significant adverse effects. Endoscopic methods, such as sclerotherapy and endoscopic variceal ligation (EVL), are highly effective in the treatment of acute variceal bleeding and eradication of varices. EVL is the treatment of choice because of minimal complications and the need for few endoscopic sessions. EVL facilitates portal decompression either by the formation of collateral vessels or by surgical portosystemic shunting, when vessels grow to the proper diameter for anastomosis. Surgical portosystemic shunts are reserved for refractory cases because of significant complications and technical difficulties. Transjugular portosystemic shunts have an emerging role in the management of portal hypertension caused by PVT. PVT may occur in the posttransplant setting, but optimal management is not defined yet.</description><identifier>ISSN: 0277-2116</identifier><identifier>EISSN: 1536-4801</identifier><identifier>DOI: 10.1097/MPG.0b013e3182a1cd7f</identifier><identifier>PMID: 23820400</identifier><identifier>CODEN: JPGND6</identifier><language>eng</language><publisher>Hagerstown, MD: by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</publisher><subject>Adrenergic beta-Antagonists - therapeutic use ; Biological and medical sciences ; Blood and lymphatic vessels ; Cardiology. Vascular system ; Child ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; endoscopic variceal ligation ; Esophageal and Gastric Varices - etiology ; Esophageal and Gastric Varices - therapy ; Feeding. Feeding behavior ; Fundamental and applied biological sciences. Psychology ; Gastroenterology. Liver. Pancreas. Abdomen ; Humans ; Hypertension, Portal - drug therapy ; Hypertension, Portal - etiology ; Hypertension, Portal - surgery ; Hypertension, Portal - therapy ; Ligation ; Liver. Biliary tract. Portal circulation. Exocrine pancreas ; Medical sciences ; Other diseases. Semiology ; Portal Vein - pathology ; Portal Vein - surgery ; portal vein thrombosis ; Portasystemic Shunt, Surgical ; sclerotherapy ; surgical portosystemic shunt ; variceal bleeding ; Venous Thrombosis - complications ; Venous Thrombosis - drug therapy ; Venous Thrombosis - surgery ; Venous Thrombosis - therapy ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>Journal of pediatric gastroenterology and nutrition, 2013-10, Vol.57 (4), p.419-425</ispartof><rights>2013 by European Society for European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology, Hepatology, and Nutrition</rights><rights>2013 by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c486f-5c68da03d7bc33992772964469ce200699e0aed5411204c1d9e171f5eac0860d3</citedby><cites>FETCH-LOGICAL-c486f-5c68da03d7bc33992772964469ce200699e0aed5411204c1d9e171f5eac0860d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1097%2FMPG.0b013e3182a1cd7f$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1097%2FMPG.0b013e3182a1cd7f$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27789030$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23820400$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Giouleme, Olga</creatorcontrib><creatorcontrib>Theocharidou, Eleni</creatorcontrib><title>Management of Portal Hypertension in Children With Portal Vein Thrombosis</title><title>Journal of pediatric gastroenterology and nutrition</title><addtitle>J Pediatr Gastroenterol Nutr</addtitle><description>ABSTRACT
Portal vein thrombosis (PVT) is a common cause of portal hypertension in children. Predisposing conditions for PVT are obscure in more than half of the cases. Variceal bleeding and splenomegaly are the most frequent initial manifestations. Radiologic imaging studies are the mainstay for diagnosis. Treatment includes pharmacologic, endoscopic, and surgical modalities. β‐Adrenergic blockers are not routinely used in children because of unproven efficacy and significant adverse effects. Endoscopic methods, such as sclerotherapy and endoscopic variceal ligation (EVL), are highly effective in the treatment of acute variceal bleeding and eradication of varices. EVL is the treatment of choice because of minimal complications and the need for few endoscopic sessions. EVL facilitates portal decompression either by the formation of collateral vessels or by surgical portosystemic shunting, when vessels grow to the proper diameter for anastomosis. Surgical portosystemic shunts are reserved for refractory cases because of significant complications and technical difficulties. Transjugular portosystemic shunts have an emerging role in the management of portal hypertension caused by PVT. PVT may occur in the posttransplant setting, but optimal management is not defined yet.</description><subject>Adrenergic beta-Antagonists - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Blood and lymphatic vessels</subject><subject>Cardiology. Vascular system</subject><subject>Child</subject><subject>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</subject><subject>endoscopic variceal ligation</subject><subject>Esophageal and Gastric Varices - etiology</subject><subject>Esophageal and Gastric Varices - therapy</subject><subject>Feeding. Feeding behavior</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Gastroenterology. Liver. Pancreas. Abdomen</subject><subject>Humans</subject><subject>Hypertension, Portal - drug therapy</subject><subject>Hypertension, Portal - etiology</subject><subject>Hypertension, Portal - surgery</subject><subject>Hypertension, Portal - therapy</subject><subject>Ligation</subject><subject>Liver. Biliary tract. Portal circulation. Exocrine pancreas</subject><subject>Medical sciences</subject><subject>Other diseases. Semiology</subject><subject>Portal Vein - pathology</subject><subject>Portal Vein - surgery</subject><subject>portal vein thrombosis</subject><subject>Portasystemic Shunt, Surgical</subject><subject>sclerotherapy</subject><subject>surgical portosystemic shunt</subject><subject>variceal bleeding</subject><subject>Venous Thrombosis - complications</subject><subject>Venous Thrombosis - drug therapy</subject><subject>Venous Thrombosis - surgery</subject><subject>Venous Thrombosis - therapy</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0277-2116</issn><issn>1536-4801</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkE1v1DAQhi0EokvhHyCUCxKXlPFH_HHgACv6pRb2UOBoeZ0JMTjxYmdV7b8n1W6LxAVOc5jnnXn0EvKSwgkFo95er85OYA2UI6eaOepb1T0iC9pwWQsN9DFZAFOqZpTKI_KslB8AoEQDT8kR45qBAFiQi2s3uu844DhVqatWKU8uVue7DeYJxxLSWIWxWvYhthnH6luY-nvoK86bmz6nYZ1KKM_Jk87Fgi8O85h8Of14szyvrz6fXSzfX9VeaNnVjZe6dcBbtfacGzMrMiOFkMYjA5DGIDhsG0HprOhpa5Aq2jXoPGgJLT8mb_Z3Nzn92mKZ7BCKxxjdiGlbLBWCC5DAmhkVe9TnVErGzm5yGFzeWQr2rkQ7l2j_LnGOvTp82K4HbB9C963NwOsD4Ip3sctu9KH84ZTSBvgdp_fcbYoT5vIzbm8x2x5dnPp_Obw7REPE3X9528vVJ_7hFKRkmv8GFTqfYA</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Giouleme, Olga</creator><creator>Theocharidou, Eleni</creator><general>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</general><general>Lippincott Williams & Wilkins</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Management of Portal Hypertension in Children With Portal Vein Thrombosis</title><author>Giouleme, Olga ; Theocharidou, Eleni</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c486f-5c68da03d7bc33992772964469ce200699e0aed5411204c1d9e171f5eac0860d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adrenergic beta-Antagonists - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Blood and lymphatic vessels</topic><topic>Cardiology. Vascular system</topic><topic>Child</topic><topic>Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous</topic><topic>endoscopic variceal ligation</topic><topic>Esophageal and Gastric Varices - etiology</topic><topic>Esophageal and Gastric Varices - therapy</topic><topic>Feeding. Feeding behavior</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>Gastroenterology. Liver. Pancreas. Abdomen</topic><topic>Humans</topic><topic>Hypertension, Portal - drug therapy</topic><topic>Hypertension, Portal - etiology</topic><topic>Hypertension, Portal - surgery</topic><topic>Hypertension, Portal - therapy</topic><topic>Ligation</topic><topic>Liver. Biliary tract. Portal circulation. Exocrine pancreas</topic><topic>Medical sciences</topic><topic>Other diseases. Semiology</topic><topic>Portal Vein - pathology</topic><topic>Portal Vein - surgery</topic><topic>portal vein thrombosis</topic><topic>Portasystemic Shunt, Surgical</topic><topic>sclerotherapy</topic><topic>surgical portosystemic shunt</topic><topic>variceal bleeding</topic><topic>Venous Thrombosis - complications</topic><topic>Venous Thrombosis - drug therapy</topic><topic>Venous Thrombosis - surgery</topic><topic>Venous Thrombosis - therapy</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Giouleme, Olga</creatorcontrib><creatorcontrib>Theocharidou, Eleni</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Giouleme, Olga</au><au>Theocharidou, Eleni</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Management of Portal Hypertension in Children With Portal Vein Thrombosis</atitle><jtitle>Journal of pediatric gastroenterology and nutrition</jtitle><addtitle>J Pediatr Gastroenterol Nutr</addtitle><date>2013-10</date><risdate>2013</risdate><volume>57</volume><issue>4</issue><spage>419</spage><epage>425</epage><pages>419-425</pages><issn>0277-2116</issn><eissn>1536-4801</eissn><coden>JPGND6</coden><abstract>ABSTRACT
Portal vein thrombosis (PVT) is a common cause of portal hypertension in children. Predisposing conditions for PVT are obscure in more than half of the cases. Variceal bleeding and splenomegaly are the most frequent initial manifestations. Radiologic imaging studies are the mainstay for diagnosis. Treatment includes pharmacologic, endoscopic, and surgical modalities. β‐Adrenergic blockers are not routinely used in children because of unproven efficacy and significant adverse effects. Endoscopic methods, such as sclerotherapy and endoscopic variceal ligation (EVL), are highly effective in the treatment of acute variceal bleeding and eradication of varices. EVL is the treatment of choice because of minimal complications and the need for few endoscopic sessions. EVL facilitates portal decompression either by the formation of collateral vessels or by surgical portosystemic shunting, when vessels grow to the proper diameter for anastomosis. Surgical portosystemic shunts are reserved for refractory cases because of significant complications and technical difficulties. Transjugular portosystemic shunts have an emerging role in the management of portal hypertension caused by PVT. PVT may occur in the posttransplant setting, but optimal management is not defined yet.</abstract><cop>Hagerstown, MD</cop><pub>by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology</pub><pmid>23820400</pmid><doi>10.1097/MPG.0b013e3182a1cd7f</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0277-2116 |
| ispartof | Journal of pediatric gastroenterology and nutrition, 2013-10, Vol.57 (4), p.419-425 |
| issn | 0277-2116 1536-4801 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1443406025 |
| source | MEDLINE; Wiley Online Library Journals Frontfile Complete; Journals@Ovid Complete |
| subjects | Adrenergic beta-Antagonists - therapeutic use Biological and medical sciences Blood and lymphatic vessels Cardiology. Vascular system Child Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous endoscopic variceal ligation Esophageal and Gastric Varices - etiology Esophageal and Gastric Varices - therapy Feeding. Feeding behavior Fundamental and applied biological sciences. Psychology Gastroenterology. Liver. Pancreas. Abdomen Humans Hypertension, Portal - drug therapy Hypertension, Portal - etiology Hypertension, Portal - surgery Hypertension, Portal - therapy Ligation Liver. Biliary tract. Portal circulation. Exocrine pancreas Medical sciences Other diseases. Semiology Portal Vein - pathology Portal Vein - surgery portal vein thrombosis Portasystemic Shunt, Surgical sclerotherapy surgical portosystemic shunt variceal bleeding Venous Thrombosis - complications Venous Thrombosis - drug therapy Venous Thrombosis - surgery Venous Thrombosis - therapy Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Management of Portal Hypertension in Children With Portal Vein Thrombosis |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-20T01%3A12%3A06IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Management%20of%20Portal%20Hypertension%20in%20Children%20With%20Portal%20Vein%20Thrombosis&rft.jtitle=Journal%20of%20pediatric%20gastroenterology%20and%20nutrition&rft.au=Giouleme,%20Olga&rft.date=2013-10&rft.volume=57&rft.issue=4&rft.spage=419&rft.epage=425&rft.pages=419-425&rft.issn=0277-2116&rft.eissn=1536-4801&rft.coden=JPGND6&rft_id=info:doi/10.1097/MPG.0b013e3182a1cd7f&rft_dat=%3Cproquest_cross%3E1443406025%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1443406025&rft_id=info:pmid/23820400&rfr_iscdi=true |