Phase 1 Clinical Trials of a Selective Rho Kinase Inhibitor, K-115

IMPORTANCE We conducted a series of phase 1 clinical trials to elucidate the efficacy and safety of the selective Rho kinase inhibitor K-115 as a candidate drug for the treatment of glaucoma. We report the intraocular pressure (IOP)–lowering effects and safety of K-115 based on our results. OBJECTIV...

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Veröffentlicht in:	JAMA ophthalmology 2013-10, Vol.131 (10), p.1288-1295
Hauptverfasser:	Tanihara, Hidenobu, Inoue, Toshihiro, Yamamoto, Tetsuya, Kuwayama, Yasuaki, Abe, Haruki, Araie, Makoto
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Topical Adult Antihypertensive Agents - administration & dosage Antihypertensive Agents - adverse effects Double-Blind Method Humans Intraocular Pressure - drug effects Isoquinolines - administration & dosage Isoquinolines - adverse effects Male Ophthalmic Solutions rho-Associated Kinases - antagonists & inhibitors Sulfonamides - administration & dosage Sulfonamides - adverse effects Tonometry, Ocular Visual Acuity Young Adult
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