Expression and clinical significance of E-cadherin and β-catenin in the vulvar squamous cell carcinoma tissues
To investigate the expression of E-cadherin and β-catenin in the Vulvar squamous cell carcinoma (VSCC) tissues. A total of 63 documented paraffin blocks of VSCC (n=41), vulvar intraepithelial neoplasia (n=22), vulvar negative cutting edge tissues (n=10) diagnosed in department of pathology of Shengj...
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| Veröffentlicht in: | Chung-hua fu chʿan kʿo tsa chih 2013-06, Vol.48 (6), p.437-441 |
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| container_title | Chung-hua fu chʿan kʿo tsa chih |
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| creator | Jia, Lin Ouyang, Ling Zhou, Yang Song, Zi-xuan Tong, Xin Li, Bo Zhang, Shi-tai He, Zheng |
| description | To investigate the expression of E-cadherin and β-catenin in the Vulvar squamous cell carcinoma (VSCC) tissues.
A total of 63 documented paraffin blocks of VSCC (n=41), vulvar intraepithelial neoplasia (n=22), vulvar negative cutting edge tissues (n=10) diagnosed in department of pathology of Shengjing Hospital of China Medical University from January 2005 to April 2012 were enrolled. EliVision immunohistochemical staining was used to detect the expression of E-cadherin and β-catenin in the three groups. Then to do a statistical analysis among the expression of them with patients' menopause status, pathological grade, clinical stage and lymph node metastasis. Spearman correlation analysis was used to analyse the expression of E-cadherin and β-catenin in the vulvar lesion tissues.
The abnormal immunoreactivity for E-cadherin [46%(19/41), 64% (14/22)] and β-catenin [61% (25/41), 68% (15/22)] in VSCC and VINII-III were found, which were significantly different from that in normal epithelium samples (P |
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A total of 63 documented paraffin blocks of VSCC (n=41), vulvar intraepithelial neoplasia (n=22), vulvar negative cutting edge tissues (n=10) diagnosed in department of pathology of Shengjing Hospital of China Medical University from January 2005 to April 2012 were enrolled. EliVision immunohistochemical staining was used to detect the expression of E-cadherin and β-catenin in the three groups. Then to do a statistical analysis among the expression of them with patients' menopause status, pathological grade, clinical stage and lymph node metastasis. Spearman correlation analysis was used to analyse the expression of E-cadherin and β-catenin in the vulvar lesion tissues.
The abnormal immunoreactivity for E-cadherin [46%(19/41), 64% (14/22)] and β-catenin [61% (25/41), 68% (15/22)] in VSCC and VINII-III were found, which were significantly different from that in normal epithelium samples (P<0.05). The</description><identifier>ISSN: 0529-567X</identifier><identifier>PMID: 24103123</identifier><language>chi</language><publisher>China</publisher><subject>Adult ; Aged ; Aged, 80 and over ; beta Catenin - genetics ; beta Catenin - metabolism ; Cadherins - metabolism ; Case-Control Studies ; Female ; Humans ; Immunohistochemistry ; Lymphatic Metastasis - pathology ; Middle Aged ; Neoplasm Staging ; Neoplasms, Squamous Cell - metabolism ; Neoplasms, Squamous Cell - pathology ; Vulvar Neoplasms - metabolism ; Vulvar Neoplasms - pathology</subject><ispartof>Chung-hua fu chʿan kʿo tsa chih, 2013-06, Vol.48 (6), p.437-441</ispartof><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24103123$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jia, Lin</creatorcontrib><creatorcontrib>Ouyang, Ling</creatorcontrib><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Song, Zi-xuan</creatorcontrib><creatorcontrib>Tong, Xin</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Zhang, Shi-tai</creatorcontrib><creatorcontrib>He, Zheng</creatorcontrib><title>Expression and clinical significance of E-cadherin and β-catenin in the vulvar squamous cell carcinoma tissues</title><title>Chung-hua fu chʿan kʿo tsa chih</title><addtitle>Zhonghua Fu Chan Ke Za Zhi</addtitle><description>To investigate the expression of E-cadherin and β-catenin in the Vulvar squamous cell carcinoma (VSCC) tissues.
A total of 63 documented paraffin blocks of VSCC (n=41), vulvar intraepithelial neoplasia (n=22), vulvar negative cutting edge tissues (n=10) diagnosed in department of pathology of Shengjing Hospital of China Medical University from January 2005 to April 2012 were enrolled. EliVision immunohistochemical staining was used to detect the expression of E-cadherin and β-catenin in the three groups. Then to do a statistical analysis among the expression of them with patients' menopause status, pathological grade, clinical stage and lymph node metastasis. Spearman correlation analysis was used to analyse the expression of E-cadherin and β-catenin in the vulvar lesion tissues.
The abnormal immunoreactivity for E-cadherin [46%(19/41), 64% (14/22)] and β-catenin [61% (25/41), 68% (15/22)] in VSCC and VINII-III were found, which were significantly different from that in normal epithelium samples (P<0.05). The</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>beta Catenin - genetics</subject><subject>beta Catenin - metabolism</subject><subject>Cadherins - metabolism</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Lymphatic Metastasis - pathology</subject><subject>Middle Aged</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Squamous Cell - metabolism</subject><subject>Neoplasms, Squamous Cell - pathology</subject><subject>Vulvar Neoplasms - metabolism</subject><subject>Vulvar Neoplasms - pathology</subject><issn>0529-567X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo1kE1qwzAQhbVoaUKaKxQtuzFII8mOlyWkP1DopoXujCyNGoEtO5Id2mv1ID1TVZLCwMxjPuY95oIsmYK6UGX1viDrlHzLFBflBnh9RRYgORMcxJIMu88xYt4Pgepgqel88EZ3NPmP4F0eg0E6OLorjLZ7jP7E_XxnPWHIMte0R3qcu6OONB1m3Q9zoga7jhodjQ9Dr-nkU5oxXZNLp7uE63Nfkbf73ev2sXh-eXja3j0XI4dyKqyqTF1b3DiNluEGtGoVlDm0rEowqkVeMWksg1YZC0xhLQAy4RxKI5xYkdvT3TEOh-w7Nb1Pf5F0wJyu4VIKyUStIKM3Z3Rue7TNGH2v41fz_yTxC7EDZS0</recordid><startdate>201306</startdate><enddate>201306</enddate><creator>Jia, Lin</creator><creator>Ouyang, Ling</creator><creator>Zhou, Yang</creator><creator>Song, Zi-xuan</creator><creator>Tong, Xin</creator><creator>Li, Bo</creator><creator>Zhang, Shi-tai</creator><creator>He, Zheng</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201306</creationdate><title>Expression and clinical significance of E-cadherin and β-catenin in the vulvar squamous cell carcinoma tissues</title><author>Jia, Lin ; Ouyang, Ling ; Zhou, Yang ; Song, Zi-xuan ; Tong, Xin ; Li, Bo ; Zhang, Shi-tai ; He, Zheng</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p126t-d57c99de8faed0e82a5b5260314762c5be1704cd02b5cd205e9322526ffe4c3f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>chi</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>beta Catenin - genetics</topic><topic>beta Catenin - metabolism</topic><topic>Cadherins - metabolism</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Lymphatic Metastasis - pathology</topic><topic>Middle Aged</topic><topic>Neoplasm Staging</topic><topic>Neoplasms, Squamous Cell - metabolism</topic><topic>Neoplasms, Squamous Cell - pathology</topic><topic>Vulvar Neoplasms - metabolism</topic><topic>Vulvar Neoplasms - pathology</topic><toplevel>online_resources</toplevel><creatorcontrib>Jia, Lin</creatorcontrib><creatorcontrib>Ouyang, Ling</creatorcontrib><creatorcontrib>Zhou, Yang</creatorcontrib><creatorcontrib>Song, Zi-xuan</creatorcontrib><creatorcontrib>Tong, Xin</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Zhang, Shi-tai</creatorcontrib><creatorcontrib>He, Zheng</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><jtitle>Chung-hua fu chʿan kʿo tsa chih</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jia, Lin</au><au>Ouyang, Ling</au><au>Zhou, Yang</au><au>Song, Zi-xuan</au><au>Tong, Xin</au><au>Li, Bo</au><au>Zhang, Shi-tai</au><au>He, Zheng</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Expression and clinical significance of E-cadherin and β-catenin in the vulvar squamous cell carcinoma tissues</atitle><jtitle>Chung-hua fu chʿan kʿo tsa chih</jtitle><addtitle>Zhonghua Fu Chan Ke Za Zhi</addtitle><date>2013-06</date><risdate>2013</risdate><volume>48</volume><issue>6</issue><spage>437</spage><epage>441</epage><pages>437-441</pages><issn>0529-567X</issn><abstract>To investigate the expression of E-cadherin and β-catenin in the Vulvar squamous cell carcinoma (VSCC) tissues.
A total of 63 documented paraffin blocks of VSCC (n=41), vulvar intraepithelial neoplasia (n=22), vulvar negative cutting edge tissues (n=10) diagnosed in department of pathology of Shengjing Hospital of China Medical University from January 2005 to April 2012 were enrolled. EliVision immunohistochemical staining was used to detect the expression of E-cadherin and β-catenin in the three groups. Then to do a statistical analysis among the expression of them with patients' menopause status, pathological grade, clinical stage and lymph node metastasis. Spearman correlation analysis was used to analyse the expression of E-cadherin and β-catenin in the vulvar lesion tissues.
The abnormal immunoreactivity for E-cadherin [46%(19/41), 64% (14/22)] and β-catenin [61% (25/41), 68% (15/22)] in VSCC and VINII-III were found, which were significantly different from that in normal epithelium samples (P<0.05). The</abstract><cop>China</cop><pmid>24103123</pmid><tpages>5</tpages></addata></record> |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals |
| subjects | Adult Aged Aged, 80 and over beta Catenin - genetics beta Catenin - metabolism Cadherins - metabolism Case-Control Studies Female Humans Immunohistochemistry Lymphatic Metastasis - pathology Middle Aged Neoplasm Staging Neoplasms, Squamous Cell - metabolism Neoplasms, Squamous Cell - pathology Vulvar Neoplasms - metabolism Vulvar Neoplasms - pathology |
| title | Expression and clinical significance of E-cadherin and β-catenin in the vulvar squamous cell carcinoma tissues |
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