Endoplasmic Reticulum Stress Participates in Aortic Valve Calcification in Hypercholesterolemic Animals

OBJECTIVES—Aortic valve (AV) calcification occurs via a pathophysiological process that includes lipoprotein deposition, inflammation, and osteoblastic differentiation of valvular interstitial cells. Here, we investigated the association between endoplasmic reticulum (ER) stress and AV calcification...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Arteriosclerosis, thrombosis, and vascular biology thrombosis, and vascular biology, 2013-10, Vol.33 (10), p.2345-2354
Hauptverfasser:	Cai, Zhejun, Li, Fei, Gong, Wei, Liu, Wanjun, Duan, Quanlu, Chen, Chen, Ni, Li, Xia, Yong, Cianflone, Katherine, Dong, Nianguo, Wang, Dao Wen
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Animals Aortic Valve - drug effects Aortic Valve - metabolism Aortic Valve - pathology Aortic Valve Stenosis - etiology Aortic Valve Stenosis - genetics Aortic Valve Stenosis - metabolism Aortic Valve Stenosis - pathology Aortic Valve Stenosis - prevention & control Apolipoproteins E - deficiency Apolipoproteins E - genetics Calcinosis - etiology Calcinosis - genetics Calcinosis - metabolism Calcinosis - pathology Calcinosis - prevention & control Calcium - metabolism Cell Differentiation Cells, Cultured Disease Models, Animal Endoplasmic Reticulum - drug effects Endoplasmic Reticulum - metabolism Endoplasmic Reticulum - pathology Endoplasmic Reticulum Stress - drug effects Female Humans Hypercholesterolemia - complications Hypercholesterolemia - drug therapy Hypercholesterolemia - genetics Hypercholesterolemia - metabolism Hypercholesterolemia - pathology Inflammation - etiology Inflammation - metabolism Inflammation - pathology Inflammation - prevention & control Inflammation Mediators - metabolism Intracellular Signaling Peptides and Proteins - genetics Intracellular Signaling Peptides and Proteins - metabolism Lipoproteins, LDL - metabolism Male Mice Mice, Knockout Middle Aged Osteoblasts - metabolism Osteoblasts - pathology Phenylbutyrates - pharmacology Rabbits RNA Interference Signal Transduction Swine Taurochenodeoxycholic Acid - pharmacology Transfection
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!