Hypoxia downregulates the expression of activating receptors involved in NK‐cell‐mediated target cell killing without affecting ADCC

In certain infection sites or tumor tissues, the disruption of homeostasis can give rise to a hypoxic microenvironment, which, in turn, can alter the function of different immune cell types and favor the progression of the disease. Natural killer (NK) cells are directly involved in the elimination o...

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Veröffentlicht in:European journal of immunology 2013-10, Vol.43 (10), p.2756-2764
Hauptverfasser: Balsamo, Mirna, Manzini, Claudia, Pietra, Gabriella, Raggi, Federica, Blengio, Fabiola, Mingari, Maria Cristina, Varesio, Luigi, Moretta, Lorenzo, Bosco, Maria Carla, Vitale, Massimo
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