Alterations of cortical excitability and central motor conduction time in Wilson's disease
•In Wilson's disease (WD) there are structural alterations of brain.•Transcranial magnetic stimulation (TMS) can evaluate neurophysiological changes.•Thirteen patients with WD were studied using TMS.•Non-recordable or high RMT and prolonged CMCT were observed in WD.•Patients with WD have widesp...
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| Veröffentlicht in: | Neuroscience letters 2013-10, Vol.553, p.90-94 |
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| creator | Jhunjhunwala, Ketan Prashanth, D.K. Netravathi, M. Nagaraju, B.C. Pal, Pramod Kr |
| description | •In Wilson's disease (WD) there are structural alterations of brain.•Transcranial magnetic stimulation (TMS) can evaluate neurophysiological changes.•Thirteen patients with WD were studied using TMS.•Non-recordable or high RMT and prolonged CMCT were observed in WD.•Patients with WD have widespread changes of cortical excitability.
Wilson's disease (WD) leads to widespread structural alterations of central nervous system and our objectives were to determine the cortical excitability changes in WD by using transcranial magnetic stimulation (TMS). Thirteen patients with WD, diagnosed by the presence of Kayser–Fleischer ring and biochemical tests, were studied. TMS was performed using a figure-of-eight coil attached to Magstim 200 stimulator. Motor evoked potentials (MEP) were recorded from right first dorsal interosseous at rest. Resting motor threshold (RMT) was determined using standard techniques and central motor conduction time (CMCT) by ‘F’ wave method. Comparison was made with control data of our laboratory. Dysarthria was the presenting symptom in 5 patients (38.5%) and chorea, tremors, dystonia and abnormal gait in 2 patients each (15.4%). RMT was recordable in 10 patients and not recordable in 3. Compared to controls, patients in whom RMT was recordable, had significantly higher mean RMT (80.9±14.8 vs. 41.1±7, p |
| doi_str_mv | 10.1016/j.neulet.2013.08.023 |
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Wilson's disease (WD) leads to widespread structural alterations of central nervous system and our objectives were to determine the cortical excitability changes in WD by using transcranial magnetic stimulation (TMS). Thirteen patients with WD, diagnosed by the presence of Kayser–Fleischer ring and biochemical tests, were studied. TMS was performed using a figure-of-eight coil attached to Magstim 200 stimulator. Motor evoked potentials (MEP) were recorded from right first dorsal interosseous at rest. Resting motor threshold (RMT) was determined using standard techniques and central motor conduction time (CMCT) by ‘F’ wave method. Comparison was made with control data of our laboratory. Dysarthria was the presenting symptom in 5 patients (38.5%) and chorea, tremors, dystonia and abnormal gait in 2 patients each (15.4%). RMT was recordable in 10 patients and not recordable in 3. Compared to controls, patients in whom RMT was recordable, had significantly higher mean RMT (80.9±14.8 vs. 41.1±7, p<0.0001) and CMCT (6.7±0.5ms vs. 4.8±0.6ms; p<0.0001). In 2 of the 3 patients with non-recordable RMT, MEP could be obtained with active contraction. CMCT in these 2 patients was also prolonged. Patients with WD have reduced cortical excitability and prolonged CMCT which may be due to the intracortical presynaptic motor dysfunction.</description><identifier>ISSN: 0304-3940</identifier><identifier>EISSN: 1872-7972</identifier><identifier>DOI: 10.1016/j.neulet.2013.08.023</identifier><identifier>PMID: 23973307</identifier><language>eng</language><publisher>Ireland: Elsevier Ireland Ltd</publisher><subject>Adolescent ; Adult ; Central motor conduction time ; Cerebral Cortex - physiopathology ; Child ; Cortical excitability ; Evoked Potentials, Motor ; Female ; Hepatolenticular Degeneration - drug therapy ; Hepatolenticular Degeneration - physiopathology ; Humans ; Magnetic Resonance Imaging ; Male ; Penicillamine - therapeutic use ; Resting motor threshold ; Time Factors ; Transcranial Magnetic Stimulation ; Wilson's disease ; Young Adult ; Zinc Sulfate - therapeutic use</subject><ispartof>Neuroscience letters, 2013-10, Vol.553, p.90-94</ispartof><rights>2013 Elsevier Ireland Ltd</rights><rights>Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c362t-645080f41340c84b2b812d98382ae1c59cf58075fd9996619d68e9b607eb5e6c3</citedby><cites>FETCH-LOGICAL-c362t-645080f41340c84b2b812d98382ae1c59cf58075fd9996619d68e9b607eb5e6c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.neulet.2013.08.023$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23973307$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Jhunjhunwala, Ketan</creatorcontrib><creatorcontrib>Prashanth, D.K.</creatorcontrib><creatorcontrib>Netravathi, M.</creatorcontrib><creatorcontrib>Nagaraju, B.C.</creatorcontrib><creatorcontrib>Pal, Pramod Kr</creatorcontrib><title>Alterations of cortical excitability and central motor conduction time in Wilson's disease</title><title>Neuroscience letters</title><addtitle>Neurosci Lett</addtitle><description>•In Wilson's disease (WD) there are structural alterations of brain.•Transcranial magnetic stimulation (TMS) can evaluate neurophysiological changes.•Thirteen patients with WD were studied using TMS.•Non-recordable or high RMT and prolonged CMCT were observed in WD.•Patients with WD have widespread changes of cortical excitability.
Wilson's disease (WD) leads to widespread structural alterations of central nervous system and our objectives were to determine the cortical excitability changes in WD by using transcranial magnetic stimulation (TMS). Thirteen patients with WD, diagnosed by the presence of Kayser–Fleischer ring and biochemical tests, were studied. TMS was performed using a figure-of-eight coil attached to Magstim 200 stimulator. Motor evoked potentials (MEP) were recorded from right first dorsal interosseous at rest. Resting motor threshold (RMT) was determined using standard techniques and central motor conduction time (CMCT) by ‘F’ wave method. Comparison was made with control data of our laboratory. Dysarthria was the presenting symptom in 5 patients (38.5%) and chorea, tremors, dystonia and abnormal gait in 2 patients each (15.4%). RMT was recordable in 10 patients and not recordable in 3. Compared to controls, patients in whom RMT was recordable, had significantly higher mean RMT (80.9±14.8 vs. 41.1±7, p<0.0001) and CMCT (6.7±0.5ms vs. 4.8±0.6ms; p<0.0001). In 2 of the 3 patients with non-recordable RMT, MEP could be obtained with active contraction. CMCT in these 2 patients was also prolonged. Patients with WD have reduced cortical excitability and prolonged CMCT which may be due to the intracortical presynaptic motor dysfunction.</description><subject>Adolescent</subject><subject>Adult</subject><subject>Central motor conduction time</subject><subject>Cerebral Cortex - physiopathology</subject><subject>Child</subject><subject>Cortical excitability</subject><subject>Evoked Potentials, Motor</subject><subject>Female</subject><subject>Hepatolenticular Degeneration - drug therapy</subject><subject>Hepatolenticular Degeneration - physiopathology</subject><subject>Humans</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Penicillamine - therapeutic use</subject><subject>Resting motor threshold</subject><subject>Time Factors</subject><subject>Transcranial Magnetic Stimulation</subject><subject>Wilson's disease</subject><subject>Young Adult</subject><subject>Zinc Sulfate - therapeutic use</subject><issn>0304-3940</issn><issn>1872-7972</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kM2KFTEQRoMozp3RNxDJTjfdVn46nWyEYVBHGHCjCG5COqmGXLqTMUmL8_b25Y4uXdWizlcfdQh5xaBnwNS7Y59wW7D1HJjoQffAxRNyYHrk3WhG_pQcQIDshJFwQS5rPQLAwAb5nFxwYUYhYDyQH9dLw-JazKnSPFOfS4veLRR_-9jcFJfYHqhLgXpMreyLNbdcdi6FzZ9itMUVaUz0e1xqTm8qDbGiq_iCPJvdUvHl47wi3z5--Hpz2919-fT55vqu80Lx1ik5gIZZMiHBaznxSTMejBaaO2R-MH4eNIzDHIwxSjETlEYzKRhxGlB5cUXenu_el_xzw9rsGqvHZXEJ81Ytk1IIo_TAd1SeUV9yrQVne1_i6sqDZWBPVu3Rnq3ak1UL2u5W99jrx4ZtWjH8C_3VuAPvzwDuf_6KWGz1EZPHEAv6ZkOO_2_4A2NeirQ</recordid><startdate>20131011</startdate><enddate>20131011</enddate><creator>Jhunjhunwala, Ketan</creator><creator>Prashanth, D.K.</creator><creator>Netravathi, M.</creator><creator>Nagaraju, B.C.</creator><creator>Pal, Pramod Kr</creator><general>Elsevier Ireland Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131011</creationdate><title>Alterations of cortical excitability and central motor conduction time in Wilson's disease</title><author>Jhunjhunwala, Ketan ; Prashanth, D.K. ; Netravathi, M. ; Nagaraju, B.C. ; Pal, Pramod Kr</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c362t-645080f41340c84b2b812d98382ae1c59cf58075fd9996619d68e9b607eb5e6c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Adult</topic><topic>Central motor conduction time</topic><topic>Cerebral Cortex - physiopathology</topic><topic>Child</topic><topic>Cortical excitability</topic><topic>Evoked Potentials, Motor</topic><topic>Female</topic><topic>Hepatolenticular Degeneration - drug therapy</topic><topic>Hepatolenticular Degeneration - physiopathology</topic><topic>Humans</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Penicillamine - therapeutic use</topic><topic>Resting motor threshold</topic><topic>Time Factors</topic><topic>Transcranial Magnetic Stimulation</topic><topic>Wilson's disease</topic><topic>Young Adult</topic><topic>Zinc Sulfate - therapeutic use</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Jhunjhunwala, Ketan</creatorcontrib><creatorcontrib>Prashanth, D.K.</creatorcontrib><creatorcontrib>Netravathi, M.</creatorcontrib><creatorcontrib>Nagaraju, B.C.</creatorcontrib><creatorcontrib>Pal, Pramod Kr</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Neuroscience letters</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Jhunjhunwala, Ketan</au><au>Prashanth, D.K.</au><au>Netravathi, M.</au><au>Nagaraju, B.C.</au><au>Pal, Pramod Kr</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Alterations of cortical excitability and central motor conduction time in Wilson's disease</atitle><jtitle>Neuroscience letters</jtitle><addtitle>Neurosci Lett</addtitle><date>2013-10-11</date><risdate>2013</risdate><volume>553</volume><spage>90</spage><epage>94</epage><pages>90-94</pages><issn>0304-3940</issn><eissn>1872-7972</eissn><abstract>•In Wilson's disease (WD) there are structural alterations of brain.•Transcranial magnetic stimulation (TMS) can evaluate neurophysiological changes.•Thirteen patients with WD were studied using TMS.•Non-recordable or high RMT and prolonged CMCT were observed in WD.•Patients with WD have widespread changes of cortical excitability.
Wilson's disease (WD) leads to widespread structural alterations of central nervous system and our objectives were to determine the cortical excitability changes in WD by using transcranial magnetic stimulation (TMS). Thirteen patients with WD, diagnosed by the presence of Kayser–Fleischer ring and biochemical tests, were studied. TMS was performed using a figure-of-eight coil attached to Magstim 200 stimulator. Motor evoked potentials (MEP) were recorded from right first dorsal interosseous at rest. Resting motor threshold (RMT) was determined using standard techniques and central motor conduction time (CMCT) by ‘F’ wave method. Comparison was made with control data of our laboratory. Dysarthria was the presenting symptom in 5 patients (38.5%) and chorea, tremors, dystonia and abnormal gait in 2 patients each (15.4%). RMT was recordable in 10 patients and not recordable in 3. Compared to controls, patients in whom RMT was recordable, had significantly higher mean RMT (80.9±14.8 vs. 41.1±7, p<0.0001) and CMCT (6.7±0.5ms vs. 4.8±0.6ms; p<0.0001). In 2 of the 3 patients with non-recordable RMT, MEP could be obtained with active contraction. CMCT in these 2 patients was also prolonged. Patients with WD have reduced cortical excitability and prolonged CMCT which may be due to the intracortical presynaptic motor dysfunction.</abstract><cop>Ireland</cop><pub>Elsevier Ireland Ltd</pub><pmid>23973307</pmid><doi>10.1016/j.neulet.2013.08.023</doi><tpages>5</tpages></addata></record> |
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| subjects | Adolescent Adult Central motor conduction time Cerebral Cortex - physiopathology Child Cortical excitability Evoked Potentials, Motor Female Hepatolenticular Degeneration - drug therapy Hepatolenticular Degeneration - physiopathology Humans Magnetic Resonance Imaging Male Penicillamine - therapeutic use Resting motor threshold Time Factors Transcranial Magnetic Stimulation Wilson's disease Young Adult Zinc Sulfate - therapeutic use |
| title | Alterations of cortical excitability and central motor conduction time in Wilson's disease |
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