Doxorubicin-Induced Vascular Dysfunction and Its Attenuation by Exercise Preconditioning

Doxorubicin (DOX) is a highly effective anthracycline antibiotic used to treat a wide array of cancers. Its use is limited because of dose-dependent cardiovascular toxicity. Although exercise training has been shown to protect against DOX-induced cardiotoxicity, it is unclear as to whether exercise...

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Veröffentlicht in:	Journal of cardiovascular pharmacology 2013-10, Vol.62 (4), p.355-360
Hauptverfasser:	Gibson, Noah M, Greufe, Stephanie E, Hydock, David S, Hayward, Reid
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antibiotics, Antineoplastic - pharmacokinetics Antibiotics, Antineoplastic - toxicity Aorta, Thoracic - drug effects Aorta, Thoracic - pathology Biological and medical sciences Cardiovascular system Doxorubicin - pharmacokinetics Doxorubicin - toxicity Endothelium, Vascular - drug effects Endothelium, Vascular - pathology Male Medical sciences Muscle, Smooth, Vascular - physiopathology Pharmacology. Drug treatments Physical Conditioning, Animal Rats Rats, Sprague-Dawley Running - physiology Tissue Distribution Vascular Diseases - chemically induced Vascular Diseases - prevention & control
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