Operative Strategy Modifies Risk of Pouch-related Outcomes in Patients With Ulcerative Colitis on Preoperative Anti-Tumor Necrosis Factor-α Therapy

BACKGROUND:Whether preoperative biological therapy increases postoperative complications after restorative proctocolectomy remains controversial. OBJECTIVE:This study aims to evaluate the influence of preoperative use of biologics on outcomes after restorative proctocolectomy and to assess whether a...

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Veröffentlicht in:	Diseases of the colon & rectum 2013-11, Vol.56 (11), p.1243-1252
Hauptverfasser:	Gu, Jinyu, Remzi, Feza H, Shen, Bo, Vogel, Jon D, Kiran, Ravi P
Format:	Artikel
Sprache:	eng
Schlagworte:	Adalimumab Adolescent Adult Aged Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - adverse effects Antibodies, Monoclonal, Humanized - administration & dosage Antibodies, Monoclonal, Humanized - adverse effects Biological and medical sciences Colitis, Ulcerative - surgery Female Gastroenterology. Liver. Pancreas. Abdomen Gastrointestinal Agents - administration & dosage Gastrointestinal Agents - adverse effects Humans Ileostomy Immunomodulators Infliximab Male Medical sciences Middle Aged Multivariate Analysis Other diseases. Semiology Pharmacology. Drug treatments Proctocolectomy, Restorative - adverse effects Proctocolectomy, Restorative - methods Proportional Hazards Models Retrospective Studies Risk Factors Sepsis - epidemiology Stomach, duodenum, intestine, rectum, anus Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases Surgery of the digestive system Tumor Necrosis Factor-alpha - antagonists & inhibitors Young Adult
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