Analysis of 2‑Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2‑Alkylcyclobutanones for Irradiated Food Identification
2-Alkylcyclobutanones (2-ACBs) have long been considered as unique radiolytic products that can be used as indicators for irradiated food identification. A recent report on the natural existence of 2-ACB in non-irradiated nutmeg and cashew nut samples aroused worldwide concern because it contradicts...
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| Veröffentlicht in: | Journal of agricultural and food chemistry 2013-10, Vol.61 (41), p.9950-9954 |
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| creator | Leung, Elvis M. K Tang, Phyllis N. Y Ye, Yuran Chan, Wan |
| description | 2-Alkylcyclobutanones (2-ACBs) have long been considered as unique radiolytic products that can be used as indicators for irradiated food identification. A recent report on the natural existence of 2-ACB in non-irradiated nutmeg and cashew nut samples aroused worldwide concern because it contradicts the general belief that 2-ACBs are specific to irradiated food. The goal of this study is to test the natural existence of 2-ACBs in nut samples using our newly developed liquid chromatography–tandem mass spectrometry (LC–MS/MS) method with enhanced analytical sensitivity and selectivity ( Ye Y. ; Liu H. ; Horvatovich P. ; Chan W. Liquid chromatography–electrospray ionization tandem mass spectrometric analysis of 2-alkylcyclobutanones in irradiated chicken by precolumn derivatization with hydroxylamine. J. Agric. Food Chem. 2013, 61, 5758−5763 ). The validated method was applied to identify 2-dodecylcyclobutanone (2-DCB) and 2-tetradecylcyclobutanone (2-TCB) in nutmeg, cashew nut, pine nut, and apricot kernel samples (n = 22) of different origins. Our study reveals that 2-DCB and 2-TCB either do not exist naturally or exist at concentrations below the detection limit of the existing method. Thus, 2-DCB and 2-TCB are still valid to be used as biomarkers for identifying irradiated food. |
| doi_str_mv | 10.1021/jf403500j |
| format | Article |
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K ; Tang, Phyllis N. Y ; Ye, Yuran ; Chan, Wan</creator><creatorcontrib>Leung, Elvis M. K ; Tang, Phyllis N. Y ; Ye, Yuran ; Chan, Wan</creatorcontrib><description>2-Alkylcyclobutanones (2-ACBs) have long been considered as unique radiolytic products that can be used as indicators for irradiated food identification. A recent report on the natural existence of 2-ACB in non-irradiated nutmeg and cashew nut samples aroused worldwide concern because it contradicts the general belief that 2-ACBs are specific to irradiated food. The goal of this study is to test the natural existence of 2-ACBs in nut samples using our newly developed liquid chromatography–tandem mass spectrometry (LC–MS/MS) method with enhanced analytical sensitivity and selectivity ( Ye Y. ; Liu H. ; Horvatovich P. ; Chan W. Liquid chromatography–electrospray ionization tandem mass spectrometric analysis of 2-alkylcyclobutanones in irradiated chicken by precolumn derivatization with hydroxylamine. J. Agric. Food Chem. 2013, 61, 5758−5763 ). The validated method was applied to identify 2-dodecylcyclobutanone (2-DCB) and 2-tetradecylcyclobutanone (2-TCB) in nutmeg, cashew nut, pine nut, and apricot kernel samples (n = 22) of different origins. Our study reveals that 2-DCB and 2-TCB either do not exist naturally or exist at concentrations below the detection limit of the existing method. Thus, 2-DCB and 2-TCB are still valid to be used as biomarkers for identifying irradiated food.</description><identifier>ISSN: 0021-8561</identifier><identifier>EISSN: 1520-5118</identifier><identifier>DOI: 10.1021/jf403500j</identifier><identifier>PMID: 24066811</identifier><identifier>CODEN: JAFCAU</identifier><language>eng</language><publisher>Washington, DC: American Chemical Society</publisher><subject>Anacardium - chemistry ; apricots ; Biological and medical sciences ; cashew nuts ; chickens ; Chromatography, Liquid - methods ; Cyclobutanes - analysis ; derivatization ; detection limit ; Food industries ; Food Irradiation ; foods ; Fundamental and applied biological sciences. Psychology ; ionization ; mass spectrometry ; Myristica fragrans - chemistry ; nutmeg ; Nuts - chemistry ; Pinus - chemistry ; Prunus - chemistry ; seeds ; Tandem Mass Spectrometry - methods ; unique radiolytic products</subject><ispartof>Journal of agricultural and food chemistry, 2013-10, Vol.61 (41), p.9950-9954</ispartof><rights>Copyright © 2013 American Chemical Society</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a435t-796a184acfa700d150a4ac83af04e1753bdd9ed1807b4d6f6a2bdf3f4ae0045a3</citedby><cites>FETCH-LOGICAL-a435t-796a184acfa700d150a4ac83af04e1753bdd9ed1807b4d6f6a2bdf3f4ae0045a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://pubs.acs.org/doi/pdf/10.1021/jf403500j$$EPDF$$P50$$Gacs$$H</linktopdf><linktohtml>$$Uhttps://pubs.acs.org/doi/10.1021/jf403500j$$EHTML$$P50$$Gacs$$H</linktohtml><link.rule.ids>314,776,780,2752,27053,27901,27902,56713,56763</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27834297$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24066811$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Leung, Elvis M. K</creatorcontrib><creatorcontrib>Tang, Phyllis N. Y</creatorcontrib><creatorcontrib>Ye, Yuran</creatorcontrib><creatorcontrib>Chan, Wan</creatorcontrib><title>Analysis of 2‑Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2‑Alkylcyclobutanones for Irradiated Food Identification</title><title>Journal of agricultural and food chemistry</title><addtitle>J. Agric. Food Chem</addtitle><description>2-Alkylcyclobutanones (2-ACBs) have long been considered as unique radiolytic products that can be used as indicators for irradiated food identification. A recent report on the natural existence of 2-ACB in non-irradiated nutmeg and cashew nut samples aroused worldwide concern because it contradicts the general belief that 2-ACBs are specific to irradiated food. The goal of this study is to test the natural existence of 2-ACBs in nut samples using our newly developed liquid chromatography–tandem mass spectrometry (LC–MS/MS) method with enhanced analytical sensitivity and selectivity ( Ye Y. ; Liu H. ; Horvatovich P. ; Chan W. Liquid chromatography–electrospray ionization tandem mass spectrometric analysis of 2-alkylcyclobutanones in irradiated chicken by precolumn derivatization with hydroxylamine. J. Agric. Food Chem. 2013, 61, 5758−5763 ). The validated method was applied to identify 2-dodecylcyclobutanone (2-DCB) and 2-tetradecylcyclobutanone (2-TCB) in nutmeg, cashew nut, pine nut, and apricot kernel samples (n = 22) of different origins. Our study reveals that 2-DCB and 2-TCB either do not exist naturally or exist at concentrations below the detection limit of the existing method. Thus, 2-DCB and 2-TCB are still valid to be used as biomarkers for identifying irradiated food.</description><subject>Anacardium - chemistry</subject><subject>apricots</subject><subject>Biological and medical sciences</subject><subject>cashew nuts</subject><subject>chickens</subject><subject>Chromatography, Liquid - methods</subject><subject>Cyclobutanes - analysis</subject><subject>derivatization</subject><subject>detection limit</subject><subject>Food industries</subject><subject>Food Irradiation</subject><subject>foods</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>ionization</subject><subject>mass spectrometry</subject><subject>Myristica fragrans - chemistry</subject><subject>nutmeg</subject><subject>Nuts - chemistry</subject><subject>Pinus - chemistry</subject><subject>Prunus - chemistry</subject><subject>seeds</subject><subject>Tandem Mass Spectrometry - methods</subject><subject>unique radiolytic products</subject><issn>0021-8561</issn><issn>1520-5118</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kc9uEzEQh1cIREPhwAuAL0ggZWG89v4JtyiiEFEBouS8mqzHqYNjp_Zuq9x4BZ6Ht-FJcJTQXhAXj6z59M1ofln2lMNrDgV_s9YSRAmwvpeNeFlAXnLe3M9GkJp5U1b8JHsU4xoAmrKGh9lJIaGqGs5H2a-pQ7uLJjKvWfH7x8-p_b6z3a6zfjn06LyjyIxjM4yXdMM-Df14_2xoNWbTbTCd79lHCo7smKFT7ItxtAfYBW62luJb9pVyukY7YG_civWXxBbOXA2UxP8dqn1g8xBQGexJsTPvFZsrcr3Rpksy7x5nDzTaSE-O9TRbnL37NvuQn39-P59Nz3OUouzzelIhbyR2GmsAxUvA9GkEapDE61IslZqQ4g3US6kqXWGxVFpoiQQgSxSn2cuDdxt8Wjz27cbEjqxFR36ILZdSiElZizqhrw5oF3yMgXSbbrTBsGs5tPus2tusEvvsqB2WG1K35N9wEvDiCGDs0OqArjPxjqsbIYvJfujzA6fRt7gKiVlcFMAlABdF0cg7E3axXfshpNDjP1b6A-n5tbU</recordid><startdate>20131016</startdate><enddate>20131016</enddate><creator>Leung, Elvis M. K</creator><creator>Tang, Phyllis N. Y</creator><creator>Ye, Yuran</creator><creator>Chan, Wan</creator><general>American Chemical Society</general><scope>FBQ</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131016</creationdate><title>Analysis of 2‑Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2‑Alkylcyclobutanones for Irradiated Food Identification</title><author>Leung, Elvis M. K ; Tang, Phyllis N. Y ; Ye, Yuran ; Chan, Wan</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-a435t-796a184acfa700d150a4ac83af04e1753bdd9ed1807b4d6f6a2bdf3f4ae0045a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Anacardium - chemistry</topic><topic>apricots</topic><topic>Biological and medical sciences</topic><topic>cashew nuts</topic><topic>chickens</topic><topic>Chromatography, Liquid - methods</topic><topic>Cyclobutanes - analysis</topic><topic>derivatization</topic><topic>detection limit</topic><topic>Food industries</topic><topic>Food Irradiation</topic><topic>foods</topic><topic>Fundamental and applied biological sciences. Psychology</topic><topic>ionization</topic><topic>mass spectrometry</topic><topic>Myristica fragrans - chemistry</topic><topic>nutmeg</topic><topic>Nuts - chemistry</topic><topic>Pinus - chemistry</topic><topic>Prunus - chemistry</topic><topic>seeds</topic><topic>Tandem Mass Spectrometry - methods</topic><topic>unique radiolytic products</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Leung, Elvis M. K</creatorcontrib><creatorcontrib>Tang, Phyllis N. Y</creatorcontrib><creatorcontrib>Ye, Yuran</creatorcontrib><creatorcontrib>Chan, Wan</creatorcontrib><collection>AGRIS</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of agricultural and food chemistry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Leung, Elvis M. K</au><au>Tang, Phyllis N. Y</au><au>Ye, Yuran</au><au>Chan, Wan</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Analysis of 2‑Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2‑Alkylcyclobutanones for Irradiated Food Identification</atitle><jtitle>Journal of agricultural and food chemistry</jtitle><addtitle>J. Agric. Food Chem</addtitle><date>2013-10-16</date><risdate>2013</risdate><volume>61</volume><issue>41</issue><spage>9950</spage><epage>9954</epage><pages>9950-9954</pages><issn>0021-8561</issn><eissn>1520-5118</eissn><coden>JAFCAU</coden><abstract>2-Alkylcyclobutanones (2-ACBs) have long been considered as unique radiolytic products that can be used as indicators for irradiated food identification. A recent report on the natural existence of 2-ACB in non-irradiated nutmeg and cashew nut samples aroused worldwide concern because it contradicts the general belief that 2-ACBs are specific to irradiated food. The goal of this study is to test the natural existence of 2-ACBs in nut samples using our newly developed liquid chromatography–tandem mass spectrometry (LC–MS/MS) method with enhanced analytical sensitivity and selectivity ( Ye Y. ; Liu H. ; Horvatovich P. ; Chan W. Liquid chromatography–electrospray ionization tandem mass spectrometric analysis of 2-alkylcyclobutanones in irradiated chicken by precolumn derivatization with hydroxylamine. J. Agric. Food Chem. 2013, 61, 5758−5763 ). The validated method was applied to identify 2-dodecylcyclobutanone (2-DCB) and 2-tetradecylcyclobutanone (2-TCB) in nutmeg, cashew nut, pine nut, and apricot kernel samples (n = 22) of different origins. Our study reveals that 2-DCB and 2-TCB either do not exist naturally or exist at concentrations below the detection limit of the existing method. Thus, 2-DCB and 2-TCB are still valid to be used as biomarkers for identifying irradiated food.</abstract><cop>Washington, DC</cop><pub>American Chemical Society</pub><pmid>24066811</pmid><doi>10.1021/jf403500j</doi><tpages>5</tpages></addata></record> |
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| subjects | Anacardium - chemistry apricots Biological and medical sciences cashew nuts chickens Chromatography, Liquid - methods Cyclobutanes - analysis derivatization detection limit Food industries Food Irradiation foods Fundamental and applied biological sciences. Psychology ionization mass spectrometry Myristica fragrans - chemistry nutmeg Nuts - chemistry Pinus - chemistry Prunus - chemistry seeds Tandem Mass Spectrometry - methods unique radiolytic products |
| title | Analysis of 2‑Alkylcyclobutanones in Cashew Nut, Nutmeg, Apricot Kernel, and Pine Nut Samples: Re-evaluating the Uniqueness of 2‑Alkylcyclobutanones for Irradiated Food Identification |
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