Thrombin-activatable fibrinolysis inhibitor protects against acute lung injury by inhibiting the complement system

Acute lung injury (ALI) is a devastating disease with an overall mortality rate of 30 to 40%. The coagulation/fibrinolysis system is implicated in the pathogenesis of ALI. Thrombin-activatable fibronolysis inhibitor (TAFI) is an important component of the fibrinolysis system. Recent studies have sho...

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Veröffentlicht in:	American journal of respiratory cell and molecular biology 2013-10, Vol.49 (4), p.646-653
Hauptverfasser:	Naito, Masahiro, Taguchi, Osamu, Kobayashi, Tetsu, Takagi, Takehiro, D'Alessandro-Gabazza, Corina N, Matsushima, Yuki, Boveda-Ruiz, Daniel, Gil-Bernabe, Paloma, Matsumoto, Takahiro, Chelakkot-Govindalayathil, Ayshwarya-Lakshmi, Toda, Masaaki, Yasukawa, Atsushi, Hataji, Osamu, Morser, John, Takei, Yoshiyuki, Gabazza, Esteban C
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Lung Injury - immunology Acute Lung Injury - metabolism Animals Blood Coagulation - immunology Bronchoalveolar Lavage Fluid - immunology Carboxypeptidase B2 - deficiency Carboxypeptidase B2 - metabolism Complement C5a - immunology Complement C5a - metabolism Cytokines - immunology Cytokines - metabolism Fibrinolysis - immunology Inflammation - immunology Inflammation - metabolism Lipopolysaccharides - immunology Lung - immunology Lung - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Neutrophils - immunology Neutrophils - metabolism Pneumonia - immunology Pneumonia - metabolism Thrombin - immunology Thrombin - metabolism
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