Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults
Objective Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk‐fa...
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| Veröffentlicht in: | Obesity (Silver Spring, Md.) Md.), 2013-10, Vol.21 (10), p.1982-1990 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Christensen, Pia Frederiksen, Rikke Bliddal, Henning Riecke, Birgit F. Bartels, Else M. Henriksen, Marius Juul‐S⊘rensen, Tina Gudbergsen, Henrik Winther, Kaj Astrup, Arne Christensen, Robin |
| description | Objective
Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk‐factors, nutritional health, and body composition after 1‐year weight‐loss maintenance achieved by [D]diet, [E]knee‐exercise, or [C]control, following weight loss by low‐energy‐diet.
Design and Methods
Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body‐mass index 37.3 kg/m2 (4.8), were enrolled into a 68‐week weight‐loss trial.
Results
Mean changes in weight, in D, E, and C were −11.0, −6.3, and −8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were −8.4, −4.6, and −7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: −3.8 cm (95%CI −6.2 to −1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups.
Conclusions
Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone. |
| doi_str_mv | 10.1002/oby.20413 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443394174</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1443394174</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3253-d626cfba127443d6a21c27ed7e3a9f4013d4c1866f0d311655cd0c174149e85a3</originalsourceid><addsrcrecordid>eNp1kMtOwzAQRS0E4r3gB5CXINFix07SLKHiJSGxAQlW0cSetIbELnbSqn-PIYUdq5nFuUdXl5ATzsacseTSVetxwiQXW2SfF4KNclG8bv_9E75HDkJ4Z0xmLOW7ZC8RKU9yKfZJmLp2Ad4EZ6mraTf3iHSFZjbvaAvGdmjBKqQL72Ye2kAjp8Br45YQVN-ApzH8cUErZ5GC1XRpOmiNDdRYGlCj7cCvqWs0egq6b7pwRHZqaAIeb-4hebm9eZ7ejx6f7h6mV48jJZJUjHSWZKqu4LupFDqDhKskR52jgKKWjAstFZ9kWc204DxLU6WZ4rnkssBJCuKQnA3eWP6zx9CVrQkKmwYsuj6UPGpFIWMioucDqrwLwWNdLrxpY_GSs_J74zJuXP5sHNnTjbavWtR_5O-oEbgcgJVpcP2_qXy6fhuUX8QPhys</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1443394174</pqid></control><display><type>article</type><title>Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults</title><source>Wiley Free Content</source><source>MEDLINE</source><source>Wiley Online Library Journals Frontfile Complete</source><creator>Christensen, Pia ; Frederiksen, Rikke ; Bliddal, Henning ; Riecke, Birgit F. ; Bartels, Else M. ; Henriksen, Marius ; Juul‐S⊘rensen, Tina ; Gudbergsen, Henrik ; Winther, Kaj ; Astrup, Arne ; Christensen, Robin</creator><creatorcontrib>Christensen, Pia ; Frederiksen, Rikke ; Bliddal, Henning ; Riecke, Birgit F. ; Bartels, Else M. ; Henriksen, Marius ; Juul‐S⊘rensen, Tina ; Gudbergsen, Henrik ; Winther, Kaj ; Astrup, Arne ; Christensen, Robin</creatorcontrib><description>Objective
Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk‐factors, nutritional health, and body composition after 1‐year weight‐loss maintenance achieved by [D]diet, [E]knee‐exercise, or [C]control, following weight loss by low‐energy‐diet.
Design and Methods
Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body‐mass index 37.3 kg/m2 (4.8), were enrolled into a 68‐week weight‐loss trial.
Results
Mean changes in weight, in D, E, and C were −11.0, −6.3, and −8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were −8.4, −4.6, and −7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: −3.8 cm (95%CI −6.2 to −1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups.
Conclusions
Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.</description><identifier>ISSN: 1930-7381</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.20413</identifier><identifier>PMID: 23512743</identifier><language>eng</language><publisher>United States</publisher><subject>Aged ; Biomarkers - blood ; Blood Pressure ; Body Composition ; Body Mass Index ; Bone and Bones - metabolism ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - prevention & control ; Cholesterol, HDL - blood ; Cholesterol, LDL - blood ; Diet ; Diet, Reducing ; Female ; Humans ; Male ; Middle Aged ; Motor Activity ; Nutritional Status ; Obesity - complications ; Obesity - physiopathology ; Obesity - therapy ; Osteoarthritis, Knee - complications ; Osteoarthritis, Knee - physiopathology ; Risk Factors ; Sedentary Lifestyle ; Treatment Outcome ; Triglycerides - blood ; Vitamins - blood ; Weight Loss</subject><ispartof>Obesity (Silver Spring, Md.), 2013-10, Vol.21 (10), p.1982-1990</ispartof><rights>Copyright © 2013 The Obesity Society</rights><rights>Copyright © 2013 The Obesity Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3253-d626cfba127443d6a21c27ed7e3a9f4013d4c1866f0d311655cd0c174149e85a3</citedby><cites>FETCH-LOGICAL-c3253-d626cfba127443d6a21c27ed7e3a9f4013d4c1866f0d311655cd0c174149e85a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Foby.20413$$EPDF$$P50$$Gwiley$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Foby.20413$$EHTML$$P50$$Gwiley$$Hfree_for_read</linktohtml><link.rule.ids>314,776,780,1411,1427,27901,27902,45550,45551,46384,46808</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23512743$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Christensen, Pia</creatorcontrib><creatorcontrib>Frederiksen, Rikke</creatorcontrib><creatorcontrib>Bliddal, Henning</creatorcontrib><creatorcontrib>Riecke, Birgit F.</creatorcontrib><creatorcontrib>Bartels, Else M.</creatorcontrib><creatorcontrib>Henriksen, Marius</creatorcontrib><creatorcontrib>Juul‐S⊘rensen, Tina</creatorcontrib><creatorcontrib>Gudbergsen, Henrik</creatorcontrib><creatorcontrib>Winther, Kaj</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Christensen, Robin</creatorcontrib><title>Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk‐factors, nutritional health, and body composition after 1‐year weight‐loss maintenance achieved by [D]diet, [E]knee‐exercise, or [C]control, following weight loss by low‐energy‐diet.
Design and Methods
Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body‐mass index 37.3 kg/m2 (4.8), were enrolled into a 68‐week weight‐loss trial.
Results
Mean changes in weight, in D, E, and C were −11.0, −6.3, and −8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were −8.4, −4.6, and −7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: −3.8 cm (95%CI −6.2 to −1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups.
Conclusions
Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.</description><subject>Aged</subject><subject>Biomarkers - blood</subject><subject>Blood Pressure</subject><subject>Body Composition</subject><subject>Body Mass Index</subject><subject>Bone and Bones - metabolism</subject><subject>Cardiovascular Diseases - etiology</subject><subject>Cardiovascular Diseases - prevention & control</subject><subject>Cholesterol, HDL - blood</subject><subject>Cholesterol, LDL - blood</subject><subject>Diet</subject><subject>Diet, Reducing</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Motor Activity</subject><subject>Nutritional Status</subject><subject>Obesity - complications</subject><subject>Obesity - physiopathology</subject><subject>Obesity - therapy</subject><subject>Osteoarthritis, Knee - complications</subject><subject>Osteoarthritis, Knee - physiopathology</subject><subject>Risk Factors</subject><subject>Sedentary Lifestyle</subject><subject>Treatment Outcome</subject><subject>Triglycerides - blood</subject><subject>Vitamins - blood</subject><subject>Weight Loss</subject><issn>1930-7381</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>EIF</sourceid><recordid>eNp1kMtOwzAQRS0E4r3gB5CXINFix07SLKHiJSGxAQlW0cSetIbELnbSqn-PIYUdq5nFuUdXl5ATzsacseTSVetxwiQXW2SfF4KNclG8bv_9E75HDkJ4Z0xmLOW7ZC8RKU9yKfZJmLp2Ad4EZ6mraTf3iHSFZjbvaAvGdmjBKqQL72Ye2kAjp8Br45YQVN-ApzH8cUErZ5GC1XRpOmiNDdRYGlCj7cCvqWs0egq6b7pwRHZqaAIeb-4hebm9eZ7ejx6f7h6mV48jJZJUjHSWZKqu4LupFDqDhKskR52jgKKWjAstFZ9kWc204DxLU6WZ4rnkssBJCuKQnA3eWP6zx9CVrQkKmwYsuj6UPGpFIWMioucDqrwLwWNdLrxpY_GSs_J74zJuXP5sHNnTjbavWtR_5O-oEbgcgJVpcP2_qXy6fhuUX8QPhys</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Christensen, Pia</creator><creator>Frederiksen, Rikke</creator><creator>Bliddal, Henning</creator><creator>Riecke, Birgit F.</creator><creator>Bartels, Else M.</creator><creator>Henriksen, Marius</creator><creator>Juul‐S⊘rensen, Tina</creator><creator>Gudbergsen, Henrik</creator><creator>Winther, Kaj</creator><creator>Astrup, Arne</creator><creator>Christensen, Robin</creator><scope>24P</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults</title><author>Christensen, Pia ; Frederiksen, Rikke ; Bliddal, Henning ; Riecke, Birgit F. ; Bartels, Else M. ; Henriksen, Marius ; Juul‐S⊘rensen, Tina ; Gudbergsen, Henrik ; Winther, Kaj ; Astrup, Arne ; Christensen, Robin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3253-d626cfba127443d6a21c27ed7e3a9f4013d4c1866f0d311655cd0c174149e85a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Aged</topic><topic>Biomarkers - blood</topic><topic>Blood Pressure</topic><topic>Body Composition</topic><topic>Body Mass Index</topic><topic>Bone and Bones - metabolism</topic><topic>Cardiovascular Diseases - etiology</topic><topic>Cardiovascular Diseases - prevention & control</topic><topic>Cholesterol, HDL - blood</topic><topic>Cholesterol, LDL - blood</topic><topic>Diet</topic><topic>Diet, Reducing</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Motor Activity</topic><topic>Nutritional Status</topic><topic>Obesity - complications</topic><topic>Obesity - physiopathology</topic><topic>Obesity - therapy</topic><topic>Osteoarthritis, Knee - complications</topic><topic>Osteoarthritis, Knee - physiopathology</topic><topic>Risk Factors</topic><topic>Sedentary Lifestyle</topic><topic>Treatment Outcome</topic><topic>Triglycerides - blood</topic><topic>Vitamins - blood</topic><topic>Weight Loss</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Christensen, Pia</creatorcontrib><creatorcontrib>Frederiksen, Rikke</creatorcontrib><creatorcontrib>Bliddal, Henning</creatorcontrib><creatorcontrib>Riecke, Birgit F.</creatorcontrib><creatorcontrib>Bartels, Else M.</creatorcontrib><creatorcontrib>Henriksen, Marius</creatorcontrib><creatorcontrib>Juul‐S⊘rensen, Tina</creatorcontrib><creatorcontrib>Gudbergsen, Henrik</creatorcontrib><creatorcontrib>Winther, Kaj</creatorcontrib><creatorcontrib>Astrup, Arne</creatorcontrib><creatorcontrib>Christensen, Robin</creatorcontrib><collection>Wiley Online Library Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Christensen, Pia</au><au>Frederiksen, Rikke</au><au>Bliddal, Henning</au><au>Riecke, Birgit F.</au><au>Bartels, Else M.</au><au>Henriksen, Marius</au><au>Juul‐S⊘rensen, Tina</au><au>Gudbergsen, Henrik</au><au>Winther, Kaj</au><au>Astrup, Arne</au><au>Christensen, Robin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2013-10</date><risdate>2013</risdate><volume>21</volume><issue>10</issue><spage>1982</spage><epage>1990</epage><pages>1982-1990</pages><issn>1930-7381</issn><eissn>1930-739X</eissn><abstract>Objective
Obese patients with knee osteoarthritis (OA) are encouraged to lose weight to obtain symptomatic relief. Risk of vascular events is higher in people with OA compared to people without arthritis. Our aim in this randomized trial was to compare changes in cardiovascular disease (CVD) risk‐factors, nutritional health, and body composition after 1‐year weight‐loss maintenance achieved by [D]diet, [E]knee‐exercise, or [C]control, following weight loss by low‐energy‐diet.
Design and Methods
Obese individuals (n = 192, >50 years) with knee OA, 63 years (SD 6), weight 103.2 kg (15.0), body‐mass index 37.3 kg/m2 (4.8), were enrolled into a 68‐week weight‐loss trial.
Results
Mean changes in weight, in D, E, and C were −11.0, −6.3, and −8.3 kg (P = 0.002). Reduction in waist circumference in D, E, and C were −8.4, −4.6, and −7.0 cm (P = 0.007). D reduced waist circumference significantly more than E: −3.8 cm (95%CI −6.2 to −1.4; P = 0.0024). There was no difference between the groups in changes in CVD risk factors; blood pressure, triglycerides, and cholesterol. Nutritional health was improved in all groups. For markers of bone, no statistical difference was found between the groups.
Conclusions
Dietary support, or control, maintained improvements in cardiovascular risk factors to the same extent and none of the interventions had a detrimental effect on bone.</abstract><cop>United States</cop><pmid>23512743</pmid><doi>10.1002/oby.20413</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2013-10, Vol.21 (10), p.1982-1990 |
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| source | Wiley Free Content; MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Aged Biomarkers - blood Blood Pressure Body Composition Body Mass Index Bone and Bones - metabolism Cardiovascular Diseases - etiology Cardiovascular Diseases - prevention & control Cholesterol, HDL - blood Cholesterol, LDL - blood Diet Diet, Reducing Female Humans Male Middle Aged Motor Activity Nutritional Status Obesity - complications Obesity - physiopathology Obesity - therapy Osteoarthritis, Knee - complications Osteoarthritis, Knee - physiopathology Risk Factors Sedentary Lifestyle Treatment Outcome Triglycerides - blood Vitamins - blood Weight Loss |
| title | Comparison of three weight maintenance programs on cardiovascular risk, bone and vitamins in sedentary older adults |
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