Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis
Abstract Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rect...
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| Veröffentlicht in: | The American journal of surgery 2013-10, Vol.206 (4), p.482-487 |
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| creator | Yu, Chang Sik, M.D Yun, Hae Ran, M.D Shin, Eung Jin, M.D Lee, Kang Yong, M.D Kim, Nam Kyu, M.D Lim, Seok-Byung, M.D Oh, Seong Taek, M.D Kang, Sung-Bum, M.D Choi, Won Joon, M.D Lee, Woo Yong, M.D |
| description | Abstract Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor ( P = .040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients. |
| doi_str_mv | 10.1016/j.amjsurg.2013.01.042 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443392574</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0002961013002948</els_id><sourcerecordid>1443392574</sourcerecordid><originalsourceid>FETCH-LOGICAL-c448t-ef79835f89c83e09e7f8446a6cb159e5fc033c281bdea8b401f9472641fdc02a3</originalsourceid><addsrcrecordid>eNqFkk1v1DAQhi0EokvhJ4Aiceklqcd2EpsDVVXxUWklDsDZ8jpj6pCPxU4q9t9jswtIvXCyZ_TMa8-8Q8hLoBVQaC77yox9XMO3ilHgFYWKCvaIbEC2qgQp-WOyoZSyUjVAz8izGPsUAgj-lJwxLoViLduQsJ2tGQr8aX3081QYt2AoJpxN16_3ZloKe4fjHEznzZKB5Q6D2R8Kn9guARa7IqBdkojNUXhTmGL6zabUuA6LtzhlUZMSh-jjc_LEmSHii9N5Tr6-f_fl5mO5_fTh9uZ6W1oh5FKia5XktZPKSo5UYeukEI1p7A5qhbWzlHPLJOw6NHInKDglWtYIcJ2lzPBzcnHU3Yf5x4px0aOPFofBpPbWqEEIzhWrW5HQ1w_Qfl5D-m-meMvrpq5louojZcMcY0Cn98GPJhw0UJ1N0b0-maKzKZqCTqakulcn9XU3Yve36o8LCbg6ApjGce8x6Gg95tH6PFrdzf6_T7x9oGAHP_lk7Xc8YPzXjY5MU_05b0ZeDOD5IiT_BTp-tns</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1437356558</pqid></control><display><type>article</type><title>Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Yu, Chang Sik, M.D ; Yun, Hae Ran, M.D ; Shin, Eung Jin, M.D ; Lee, Kang Yong, M.D ; Kim, Nam Kyu, M.D ; Lim, Seok-Byung, M.D ; Oh, Seong Taek, M.D ; Kang, Sung-Bum, M.D ; Choi, Won Joon, M.D ; Lee, Woo Yong, M.D</creator><creatorcontrib>Yu, Chang Sik, M.D ; Yun, Hae Ran, M.D ; Shin, Eung Jin, M.D ; Lee, Kang Yong, M.D ; Kim, Nam Kyu, M.D ; Lim, Seok-Byung, M.D ; Oh, Seong Taek, M.D ; Kang, Sung-Bum, M.D ; Choi, Won Joon, M.D ; Lee, Woo Yong, M.D ; Colorectal Cancer Study Group, Korean Society of Coloproctology</creatorcontrib><description>Abstract Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor ( P = .040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.</description><identifier>ISSN: 0002-9610</identifier><identifier>EISSN: 1879-1883</identifier><identifier>DOI: 10.1016/j.amjsurg.2013.01.042</identifier><identifier>PMID: 23849272</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Chemoradiotherapy ; Chemotherapy ; Colorectal cancer ; Female ; Humans ; Local excision ; Male ; Medical imaging ; Middle Aged ; Mortality ; Neoadjuvant chemoradiation therapy ; Neoadjuvant Therapy ; Neoplasm Metastasis ; Neoplasm Recurrence, Local ; NMR ; Nuclear magnetic resonance ; Rectal cancer ; Rectal Neoplasms - mortality ; Rectal Neoplasms - pathology ; Rectal Neoplasms - therapy ; Rectum - surgery ; Retrospective Studies ; Surgery</subject><ispartof>The American journal of surgery, 2013-10, Vol.206 (4), p.482-487</ispartof><rights>Elsevier Inc.</rights><rights>2013 Elsevier Inc.</rights><rights>Copyright © 2013 Elsevier Inc. All rights reserved.</rights><rights>Copyright Elsevier Limited Oct 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c448t-ef79835f89c83e09e7f8446a6cb159e5fc033c281bdea8b401f9472641fdc02a3</citedby><cites>FETCH-LOGICAL-c448t-ef79835f89c83e09e7f8446a6cb159e5fc033c281bdea8b401f9472641fdc02a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1437356558?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23849272$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Chang Sik, M.D</creatorcontrib><creatorcontrib>Yun, Hae Ran, M.D</creatorcontrib><creatorcontrib>Shin, Eung Jin, M.D</creatorcontrib><creatorcontrib>Lee, Kang Yong, M.D</creatorcontrib><creatorcontrib>Kim, Nam Kyu, M.D</creatorcontrib><creatorcontrib>Lim, Seok-Byung, M.D</creatorcontrib><creatorcontrib>Oh, Seong Taek, M.D</creatorcontrib><creatorcontrib>Kang, Sung-Bum, M.D</creatorcontrib><creatorcontrib>Choi, Won Joon, M.D</creatorcontrib><creatorcontrib>Lee, Woo Yong, M.D</creatorcontrib><creatorcontrib>Colorectal Cancer Study Group, Korean Society of Coloproctology</creatorcontrib><title>Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis</title><title>The American journal of surgery</title><addtitle>Am J Surg</addtitle><description>Abstract Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor ( P = .040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Chemoradiotherapy</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Female</subject><subject>Humans</subject><subject>Local excision</subject><subject>Male</subject><subject>Medical imaging</subject><subject>Middle Aged</subject><subject>Mortality</subject><subject>Neoadjuvant chemoradiation therapy</subject><subject>Neoadjuvant Therapy</subject><subject>Neoplasm Metastasis</subject><subject>Neoplasm Recurrence, Local</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Rectal cancer</subject><subject>Rectal Neoplasms - mortality</subject><subject>Rectal Neoplasms - pathology</subject><subject>Rectal Neoplasms - therapy</subject><subject>Rectum - surgery</subject><subject>Retrospective Studies</subject><subject>Surgery</subject><issn>0002-9610</issn><issn>1879-1883</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqFkk1v1DAQhi0EokvhJ4Aiceklqcd2EpsDVVXxUWklDsDZ8jpj6pCPxU4q9t9jswtIvXCyZ_TMa8-8Q8hLoBVQaC77yox9XMO3ilHgFYWKCvaIbEC2qgQp-WOyoZSyUjVAz8izGPsUAgj-lJwxLoViLduQsJ2tGQr8aX3081QYt2AoJpxN16_3ZloKe4fjHEznzZKB5Q6D2R8Kn9guARa7IqBdkojNUXhTmGL6zabUuA6LtzhlUZMSh-jjc_LEmSHii9N5Tr6-f_fl5mO5_fTh9uZ6W1oh5FKia5XktZPKSo5UYeukEI1p7A5qhbWzlHPLJOw6NHInKDglWtYIcJ2lzPBzcnHU3Yf5x4px0aOPFofBpPbWqEEIzhWrW5HQ1w_Qfl5D-m-meMvrpq5louojZcMcY0Cn98GPJhw0UJ1N0b0-maKzKZqCTqakulcn9XU3Yve36o8LCbg6ApjGce8x6Gg95tH6PFrdzf6_T7x9oGAHP_lk7Xc8YPzXjY5MU_05b0ZeDOD5IiT_BTp-tns</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Yu, Chang Sik, M.D</creator><creator>Yun, Hae Ran, M.D</creator><creator>Shin, Eung Jin, M.D</creator><creator>Lee, Kang Yong, M.D</creator><creator>Kim, Nam Kyu, M.D</creator><creator>Lim, Seok-Byung, M.D</creator><creator>Oh, Seong Taek, M.D</creator><creator>Kang, Sung-Bum, M.D</creator><creator>Choi, Won Joon, M.D</creator><creator>Lee, Woo Yong, M.D</creator><general>Elsevier Inc</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis</title><author>Yu, Chang Sik, M.D ; Yun, Hae Ran, M.D ; Shin, Eung Jin, M.D ; Lee, Kang Yong, M.D ; Kim, Nam Kyu, M.D ; Lim, Seok-Byung, M.D ; Oh, Seong Taek, M.D ; Kang, Sung-Bum, M.D ; Choi, Won Joon, M.D ; Lee, Woo Yong, M.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c448t-ef79835f89c83e09e7f8446a6cb159e5fc033c281bdea8b401f9472641fdc02a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Chemoradiotherapy</topic><topic>Chemotherapy</topic><topic>Colorectal cancer</topic><topic>Female</topic><topic>Humans</topic><topic>Local excision</topic><topic>Male</topic><topic>Medical imaging</topic><topic>Middle Aged</topic><topic>Mortality</topic><topic>Neoadjuvant chemoradiation therapy</topic><topic>Neoadjuvant Therapy</topic><topic>Neoplasm Metastasis</topic><topic>Neoplasm Recurrence, Local</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Rectal cancer</topic><topic>Rectal Neoplasms - mortality</topic><topic>Rectal Neoplasms - pathology</topic><topic>Rectal Neoplasms - therapy</topic><topic>Rectum - surgery</topic><topic>Retrospective Studies</topic><topic>Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Chang Sik, M.D</creatorcontrib><creatorcontrib>Yun, Hae Ran, M.D</creatorcontrib><creatorcontrib>Shin, Eung Jin, M.D</creatorcontrib><creatorcontrib>Lee, Kang Yong, M.D</creatorcontrib><creatorcontrib>Kim, Nam Kyu, M.D</creatorcontrib><creatorcontrib>Lim, Seok-Byung, M.D</creatorcontrib><creatorcontrib>Oh, Seong Taek, M.D</creatorcontrib><creatorcontrib>Kang, Sung-Bum, M.D</creatorcontrib><creatorcontrib>Choi, Won Joon, M.D</creatorcontrib><creatorcontrib>Lee, Woo Yong, M.D</creatorcontrib><creatorcontrib>Colorectal Cancer Study Group, Korean Society of Coloproctology</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>The American journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Chang Sik, M.D</au><au>Yun, Hae Ran, M.D</au><au>Shin, Eung Jin, M.D</au><au>Lee, Kang Yong, M.D</au><au>Kim, Nam Kyu, M.D</au><au>Lim, Seok-Byung, M.D</au><au>Oh, Seong Taek, M.D</au><au>Kang, Sung-Bum, M.D</au><au>Choi, Won Joon, M.D</au><au>Lee, Woo Yong, M.D</au><aucorp>Colorectal Cancer Study Group, Korean Society of Coloproctology</aucorp><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis</atitle><jtitle>The American journal of surgery</jtitle><addtitle>Am J Surg</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>206</volume><issue>4</issue><spage>482</spage><epage>487</epage><pages>482-487</pages><issn>0002-9610</issn><eissn>1879-1883</eissn><abstract>Abstract Background The aim of the current study was to evaluate the clinical availability of local excision (LE) for advanced rectal cancer without lymph node metastasis after neoadjuvant chemoradiation therapy (nCRT) in Korea. Methods From June 2000 to October 2009, 40 patients with cT2-3N0M0 rectal cancer underwent nCRT followed by LE according to a retrospective multicenter analysis. Results Of the 40 patients, 22 were men and 18 were women. Eighteen patients were cT2, and 22 patients were cT3. The median follow-up duration was 38 months. Three patients (7.5%) had morbidity after LE. Four patients (10%) had recurrence (local recurrence [1 patient] and systemic metastasis [3 patients]). The 3-year disease-free survival rate was 85.9%. Only pCR was a recurrence-related prognostic factor ( P = .040). Conclusions Although the current study was not a randomized controlled study, LE after nCRT in T2-3N0 rectal cancer patients appears to be a safe and effective treatment, especially in pCR patients.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23849272</pmid><doi>10.1016/j.amjsurg.2013.01.042</doi><tpages>6</tpages></addata></record> |
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| subjects | Adult Aged Aged, 80 and over Chemoradiotherapy Chemotherapy Colorectal cancer Female Humans Local excision Male Medical imaging Middle Aged Mortality Neoadjuvant chemoradiation therapy Neoadjuvant Therapy Neoplasm Metastasis Neoplasm Recurrence, Local NMR Nuclear magnetic resonance Rectal cancer Rectal Neoplasms - mortality Rectal Neoplasms - pathology Rectal Neoplasms - therapy Rectum - surgery Retrospective Studies Surgery |
| title | Local excision after neoadjuvant chemoradiation therapy in advanced rectal cancer: a national multicenter analysis |
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