Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis
Objective: The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis. Setting: Systematic Review. Methods: Searching relevant articles was performed in Ovid data base, Medline (PubMed) E...
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| creator | Latifi, S Koushki, D Norouzi Javidan, A Matin, M Sabour, H |
| description | Objective:
The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis.
Setting:
Systematic Review.
Methods:
Searching relevant articles was performed in Ovid data base, Medline (PubMed) EMBASE, Google Scholar, Cochrane and Scopus up to February 2013. Five articles were selected using two independent reviewers. Analysis were performed using SPSS version 18 and Comparative Meta-analysis software version 2.0.
Results:
The combined analysis with confidence interval of 95% using comprehensive meta-analysis showed significant higher leptin levels in patients with spinal cord injury in comparison with able bodies (
P |
| doi_str_mv | 10.1038/sc.2013.82 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443392015</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1443378057</sourcerecordid><originalsourceid>FETCH-LOGICAL-c420t-c87b5743657652978e5550a0679f38ddfc235e2a6ef7b72c4bf55984fac7c7f03</originalsourceid><addsrcrecordid>eNqNkU1Lw0AQhhdRbK1e_AES8CJK6mY_srveSvELKl70athsd21KmsSdBOm_d2OriF48zTDvwzvMvAgdJ3icYCovwYwJTuhYkh00TJhIY54Stht6mpKYUUUH6ABgiTFWiZL7aECoUirBcohepgtdvVqIahfNbNMWVWTqytiq9bot6ioKg6bUsNKfXZgFCaL3ol1E0BSVLgPv50Fcdn59FU2iB9vqWAdhDQUcoj2nS7BH2zpCzzfXT9O7ePZ4ez-dzGLDCG5jI0XOBaMpFyknSkjLOccap0I5KudzZwjllujUOpELYljuOFeSOW2EEQ7TETrb-Da-fusstNmqAGPLUle27iBLGKNUhS_x_6FCYi4CevoLXdadD6f1VLATWIieOt9QxtcA3rqs8cVK-3WW4KwPKAOT9QFlkgT4ZGvZ5Ss7_0a_EgnAxQaAIIVk_I-df-0-APv8l_I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1439270777</pqid></control><display><type>article</type><title>Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis</title><source>MEDLINE</source><source>Springer Nature - Complete Springer Journals</source><source>EZB-FREE-00999 freely available EZB journals</source><creator>Latifi, S ; Koushki, D ; Norouzi Javidan, A ; Matin, M ; Sabour, H</creator><creatorcontrib>Latifi, S ; Koushki, D ; Norouzi Javidan, A ; Matin, M ; Sabour, H</creatorcontrib><description>Objective:
The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis.
Setting:
Systematic Review.
Methods:
Searching relevant articles was performed in Ovid data base, Medline (PubMed) EMBASE, Google Scholar, Cochrane and Scopus up to February 2013. Five articles were selected using two independent reviewers. Analysis were performed using SPSS version 18 and Comparative Meta-analysis software version 2.0.
Results:
The combined analysis with confidence interval of 95% using comprehensive meta-analysis showed significant higher leptin levels in patients with spinal cord injury in comparison with able bodies (
P
<0.0001). The effect of spinal lesion level on plasma leptin concentration was also statistically significant (
P
<0.0001). Body mass index was positively related to plasma leptin concentration in both groups (
P
<0.0001).
Conclusion:
This Meta analysis approves increased level of leptin in spinal cord injured patients which can be due to fat distribution changes and sympathetic dysfunction in these patients. Our results also showed that patients with higher spinal lesion level have higher plasma leptin concentration.</description><identifier>ISSN: 1362-4393</identifier><identifier>EISSN: 1476-5624</identifier><identifier>DOI: 10.1038/sc.2013.82</identifier><identifier>PMID: 23999108</identifier><identifier>CODEN: SPCOFM</identifier><language>eng</language><publisher>London: Nature Publishing Group UK</publisher><subject>631/45/776/1178 ; 692/699/375/1824 ; 692/700/478/174 ; Anatomy ; Biomarkers - blood ; Biomedical and Life Sciences ; Biomedicine ; Body Mass Index ; Embolism, Fat - metabolism ; Human Physiology ; Humans ; Leptin - blood ; Neurochemistry ; Neuropsychology ; Neurosciences ; Predictive Value of Tests ; review ; Spinal Cord Injuries - blood ; Spinal Cord Injuries - pathology</subject><ispartof>Spinal cord, 2013-10, Vol.51 (10), p.728-731</ispartof><rights>International Spinal Cord Society 2013</rights><rights>Copyright Nature Publishing Group Oct 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-c87b5743657652978e5550a0679f38ddfc235e2a6ef7b72c4bf55984fac7c7f03</citedby><cites>FETCH-LOGICAL-c420t-c87b5743657652978e5550a0679f38ddfc235e2a6ef7b72c4bf55984fac7c7f03</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/sc.2013.82$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/sc.2013.82$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23999108$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Latifi, S</creatorcontrib><creatorcontrib>Koushki, D</creatorcontrib><creatorcontrib>Norouzi Javidan, A</creatorcontrib><creatorcontrib>Matin, M</creatorcontrib><creatorcontrib>Sabour, H</creatorcontrib><title>Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis</title><title>Spinal cord</title><addtitle>Spinal Cord</addtitle><addtitle>Spinal Cord</addtitle><description>Objective:
The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis.
Setting:
Systematic Review.
Methods:
Searching relevant articles was performed in Ovid data base, Medline (PubMed) EMBASE, Google Scholar, Cochrane and Scopus up to February 2013. Five articles were selected using two independent reviewers. Analysis were performed using SPSS version 18 and Comparative Meta-analysis software version 2.0.
Results:
The combined analysis with confidence interval of 95% using comprehensive meta-analysis showed significant higher leptin levels in patients with spinal cord injury in comparison with able bodies (
P
<0.0001). The effect of spinal lesion level on plasma leptin concentration was also statistically significant (
P
<0.0001). Body mass index was positively related to plasma leptin concentration in both groups (
P
<0.0001).
Conclusion:
This Meta analysis approves increased level of leptin in spinal cord injured patients which can be due to fat distribution changes and sympathetic dysfunction in these patients. Our results also showed that patients with higher spinal lesion level have higher plasma leptin concentration.</description><subject>631/45/776/1178</subject><subject>692/699/375/1824</subject><subject>692/700/478/174</subject><subject>Anatomy</subject><subject>Biomarkers - blood</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Body Mass Index</subject><subject>Embolism, Fat - metabolism</subject><subject>Human Physiology</subject><subject>Humans</subject><subject>Leptin - blood</subject><subject>Neurochemistry</subject><subject>Neuropsychology</subject><subject>Neurosciences</subject><subject>Predictive Value of Tests</subject><subject>review</subject><subject>Spinal Cord Injuries - blood</subject><subject>Spinal Cord Injuries - pathology</subject><issn>1362-4393</issn><issn>1476-5624</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkU1Lw0AQhhdRbK1e_AES8CJK6mY_srveSvELKl70athsd21KmsSdBOm_d2OriF48zTDvwzvMvAgdJ3icYCovwYwJTuhYkh00TJhIY54Stht6mpKYUUUH6ABgiTFWiZL7aECoUirBcohepgtdvVqIahfNbNMWVWTqytiq9bot6ioKg6bUsNKfXZgFCaL3ol1E0BSVLgPv50Fcdn59FU2iB9vqWAdhDQUcoj2nS7BH2zpCzzfXT9O7ePZ4ez-dzGLDCG5jI0XOBaMpFyknSkjLOccap0I5KudzZwjllujUOpELYljuOFeSOW2EEQ7TETrb-Da-fusstNmqAGPLUle27iBLGKNUhS_x_6FCYi4CevoLXdadD6f1VLATWIieOt9QxtcA3rqs8cVK-3WW4KwPKAOT9QFlkgT4ZGvZ5Ss7_0a_EgnAxQaAIIVk_I-df-0-APv8l_I</recordid><startdate>20131001</startdate><enddate>20131001</enddate><creator>Latifi, S</creator><creator>Koushki, D</creator><creator>Norouzi Javidan, A</creator><creator>Matin, M</creator><creator>Sabour, H</creator><general>Nature Publishing Group UK</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QL</scope><scope>7RV</scope><scope>7T7</scope><scope>7TK</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20131001</creationdate><title>Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis</title><author>Latifi, S ; Koushki, D ; Norouzi Javidan, A ; Matin, M ; Sabour, H</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-c87b5743657652978e5550a0679f38ddfc235e2a6ef7b72c4bf55984fac7c7f03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>631/45/776/1178</topic><topic>692/699/375/1824</topic><topic>692/700/478/174</topic><topic>Anatomy</topic><topic>Biomarkers - blood</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Body Mass Index</topic><topic>Embolism, Fat - metabolism</topic><topic>Human Physiology</topic><topic>Humans</topic><topic>Leptin - blood</topic><topic>Neurochemistry</topic><topic>Neuropsychology</topic><topic>Neurosciences</topic><topic>Predictive Value of Tests</topic><topic>review</topic><topic>Spinal Cord Injuries - blood</topic><topic>Spinal Cord Injuries - pathology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Latifi, S</creatorcontrib><creatorcontrib>Koushki, D</creatorcontrib><creatorcontrib>Norouzi Javidan, A</creatorcontrib><creatorcontrib>Matin, M</creatorcontrib><creatorcontrib>Sabour, H</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Proquest Nursing & Allied Health Source</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Neurosciences Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Spinal cord</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Latifi, S</au><au>Koushki, D</au><au>Norouzi Javidan, A</au><au>Matin, M</au><au>Sabour, H</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis</atitle><jtitle>Spinal cord</jtitle><stitle>Spinal Cord</stitle><addtitle>Spinal Cord</addtitle><date>2013-10-01</date><risdate>2013</risdate><volume>51</volume><issue>10</issue><spage>728</spage><epage>731</epage><pages>728-731</pages><issn>1362-4393</issn><eissn>1476-5624</eissn><coden>SPCOFM</coden><abstract>Objective:
The aim of this study was to investigate changes of leptin concentration in plasma in patients with spinal cord injury to come to a single concept by using a Meta-analysis.
Setting:
Systematic Review.
Methods:
Searching relevant articles was performed in Ovid data base, Medline (PubMed) EMBASE, Google Scholar, Cochrane and Scopus up to February 2013. Five articles were selected using two independent reviewers. Analysis were performed using SPSS version 18 and Comparative Meta-analysis software version 2.0.
Results:
The combined analysis with confidence interval of 95% using comprehensive meta-analysis showed significant higher leptin levels in patients with spinal cord injury in comparison with able bodies (
P
<0.0001). The effect of spinal lesion level on plasma leptin concentration was also statistically significant (
P
<0.0001). Body mass index was positively related to plasma leptin concentration in both groups (
P
<0.0001).
Conclusion:
This Meta analysis approves increased level of leptin in spinal cord injured patients which can be due to fat distribution changes and sympathetic dysfunction in these patients. Our results also showed that patients with higher spinal lesion level have higher plasma leptin concentration.</abstract><cop>London</cop><pub>Nature Publishing Group UK</pub><pmid>23999108</pmid><doi>10.1038/sc.2013.82</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1362-4393 |
| ispartof | Spinal cord, 2013-10, Vol.51 (10), p.728-731 |
| issn | 1362-4393 1476-5624 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1443392015 |
| source | MEDLINE; Springer Nature - Complete Springer Journals; EZB-FREE-00999 freely available EZB journals |
| subjects | 631/45/776/1178 692/699/375/1824 692/700/478/174 Anatomy Biomarkers - blood Biomedical and Life Sciences Biomedicine Body Mass Index Embolism, Fat - metabolism Human Physiology Humans Leptin - blood Neurochemistry Neuropsychology Neurosciences Predictive Value of Tests review Spinal Cord Injuries - blood Spinal Cord Injuries - pathology |
| title | Changes of Leptin concentration in plasma in patients with spinal cord injury: A Meta-analysis |
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