Valproate reduces collagen and osteonectin in cultured bone cells

Highlights • The long-term side effects of valproate can include bone loss, although the exact mechanism for this is currently unknown. • Here we show that valproate treatment reduces collagen I and osteonectin in an osteoblast-like cell line. • Collagen I is the main protein in bone matrix and oste...

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Veröffentlicht in:	Epilepsy research 2013-10, Vol.106 (3), p.446-450
Hauptverfasser:	Humphrey, Emma L, Morris, Glenn E, Fuller, Heidi R
Format:	Artikel
Sprache:	eng
Schlagworte:	Anticonvulsants - pharmacology Biological and medical sciences Blotting, Western Bone Bone and Bones - cytology Bone and Bones - drug effects Bone and Bones - metabolism Bone Matrix - drug effects Bone Matrix - metabolism Cell Differentiation - drug effects Cell Line Collagen Collagen Type I - metabolism Drug toxicity and drugs side effects treatment Fluorescent Antibody Technique HDAC hFOB1.19 Humans Lamin Type A - metabolism Medical sciences Neurology Osteoblasts - metabolism Osteonectin Osteonectin - metabolism Pharmacology. Drug treatments RANK Ligand - metabolism Stem Cells - metabolism Toxicity: osteoarticular system Valproate Valproic Acid - pharmacology
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