The external validity of MRI-defined vascular depression
Objective Multiple diagnostic criteria have been used to define vascular depression (VD). As a result, there are discrepancies in the clinical characteristics that have been established for the illness. The aim of this study was twofold. First, we used empirically established diagnostic criteria to...
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Veröffentlicht in: | International journal of geriatric psychiatry 2013-11, Vol.28 (11), p.1189-1196 |
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container_title | International journal of geriatric psychiatry |
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creator | Pimontel, Monique A. Reinlieb, Michelle E. Johnert, Lauren C. Garcon, Ernst Sneed, Joel R. Roose, Steven P. |
description | Objective
Multiple diagnostic criteria have been used to define vascular depression (VD). As a result, there are discrepancies in the clinical characteristics that have been established for the illness. The aim of this study was twofold. First, we used empirically established diagnostic criteria to determine the clinical characteristics of magnetic resonance imaging (MRI)‐defined VD. Second, we assessed the agreement between a quantitative and qualitative method for identifying the illness.
Method
We examined the baseline clinical and neuropsychological profile of 38 patients from a larger, double‐blind, randomized, 12‐week clinical trial comparing nortriptyline with sertraline in depressed older adults. Ten patients met quantitative criteria for MRI‐defined VD based on the highest quartile of deep white matter hyperintensity (DWMH) volume. Fourteen patients met qualitative criteria for MRI‐defined VD based on a DWMH score of 2 or higher on the Fazekas' modified Coffey rating scale.
Results
Age, gender, cumulative illness rating scale‐geriatric (CIRS‐G) score, two measures of psychomotor retardation [the psychomotor retardation item of the Hamilton Rating Scale for Depression (HRSD) as well as performance on the Purdue Pegboard], and performance on the Stroop Color/Word test (a measure of the response inhibition component of executive functioning) were significantly different between those with VD and non‐VD.
Conclusions
Patients with VD have a distinct clinical and neuropsychological profile that is mostly consistent across different methods for identifying the illness. These findings support the notion that MRI‐defined VD represents a unique and valid subtype of late‐life depression. Copyright © 2013 John Wiley & Sons, Ltd. |
doi_str_mv | 10.1002/gps.3943 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1443388705</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>3096114741</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4173-25366c76f6c2a35e2bac3b79c96bcaae3ccce5f926c967ae3c834e6f615b3e033</originalsourceid><addsrcrecordid>eNp10F1LHDEUBuBQKnW1BX9BGSiCN6NJTiaZuSx-rJZVi27xMmQyZ9rY2Zk12VH335upo0LBq5CTh_eQl5AdRvcZpfzg9zLsQyHgA5kwWhQpY1J-JBOa51kqOdBNshXCLaXxjeWfyCYHIZQAPiH5_A8m-LhC35omuTeNq9xqnXR1cn51llZYuxarOA-2b4xPKlx6DMF17WeyUZsm4Jfx3Ca_To7nh6fp7HJ6dvh9llrBFKQ8AymtkrW03ECGvDQWSlXYQpbWGARrLWZ1wWWcqOGeg8DIWVYCUoBtsvecu_TdXY9hpRcuWGwa02LXB82EAMhzRbNIv_1Hb7t--Nc_xYAxyvlboPVdCB5rvfRuYfxaM6qHNnVsUw9tRvp1DOzLBVav8KW-CHZHEAsyTe1Na114c0opoWAISp_dg2tw_e5CPf15PS4evQsrfHz1xv_VUoHK9M3FVM_E-Q86PZrrU3gCosqYYA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1441311022</pqid></control><display><type>article</type><title>The external validity of MRI-defined vascular depression</title><source>MEDLINE</source><source>Access via Wiley Online Library</source><creator>Pimontel, Monique A. ; Reinlieb, Michelle E. ; Johnert, Lauren C. ; Garcon, Ernst ; Sneed, Joel R. ; Roose, Steven P.</creator><creatorcontrib>Pimontel, Monique A. ; Reinlieb, Michelle E. ; Johnert, Lauren C. ; Garcon, Ernst ; Sneed, Joel R. ; Roose, Steven P.</creatorcontrib><description>Objective
Multiple diagnostic criteria have been used to define vascular depression (VD). As a result, there are discrepancies in the clinical characteristics that have been established for the illness. The aim of this study was twofold. First, we used empirically established diagnostic criteria to determine the clinical characteristics of magnetic resonance imaging (MRI)‐defined VD. Second, we assessed the agreement between a quantitative and qualitative method for identifying the illness.
Method
We examined the baseline clinical and neuropsychological profile of 38 patients from a larger, double‐blind, randomized, 12‐week clinical trial comparing nortriptyline with sertraline in depressed older adults. Ten patients met quantitative criteria for MRI‐defined VD based on the highest quartile of deep white matter hyperintensity (DWMH) volume. Fourteen patients met qualitative criteria for MRI‐defined VD based on a DWMH score of 2 or higher on the Fazekas' modified Coffey rating scale.
Results
Age, gender, cumulative illness rating scale‐geriatric (CIRS‐G) score, two measures of psychomotor retardation [the psychomotor retardation item of the Hamilton Rating Scale for Depression (HRSD) as well as performance on the Purdue Pegboard], and performance on the Stroop Color/Word test (a measure of the response inhibition component of executive functioning) were significantly different between those with VD and non‐VD.
Conclusions
Patients with VD have a distinct clinical and neuropsychological profile that is mostly consistent across different methods for identifying the illness. These findings support the notion that MRI‐defined VD represents a unique and valid subtype of late‐life depression. Copyright © 2013 John Wiley & Sons, Ltd.</description><identifier>ISSN: 0885-6230</identifier><identifier>EISSN: 1099-1166</identifier><identifier>DOI: 10.1002/gps.3943</identifier><identifier>PMID: 23447432</identifier><identifier>CODEN: IJGPES</identifier><language>eng</language><publisher>Hove: Blackwell Publishing Ltd</publisher><subject>Age Factors ; Aged ; Aged, 80 and over ; Antidepressive Agents - therapeutic use ; Biological and medical sciences ; Cerebrovascular Disorders - diagnosis ; Cerebrovascular Disorders - physiopathology ; clinical characteristics ; Comparative analysis ; Depressive Disorder - diagnosis ; Depressive Disorder - drug therapy ; Depressive Disorder - physiopathology ; Double-Blind Method ; external validity ; Female ; General aspects ; Geriatric Assessment - methods ; Geriatric psychiatry ; Geriatric psychology ; Geriatrics ; Humans ; late-life depression ; Magnetic Resonance Imaging ; Male ; Medical sciences ; Mental depression ; Middle Aged ; Miscellaneous ; MRI ; Neuropsychological Tests ; Neuropsychology ; NMR ; Nortriptyline - therapeutic use ; Nuclear magnetic resonance ; Psychiatric Status Rating Scales ; Psychology. Psychoanalysis. Psychiatry ; Psychomotor Performance - physiology ; Psychopathology. Psychiatry ; Public health. Hygiene ; Public health. Hygiene-occupational medicine ; Qualitative research ; Reproducibility of Results ; Sertraline - therapeutic use ; Sex Factors ; vascular depression</subject><ispartof>International journal of geriatric psychiatry, 2013-11, Vol.28 (11), p.1189-1196</ispartof><rights>Copyright © 2013 John Wiley & Sons, Ltd.</rights><rights>2015 INIST-CNRS</rights><rights>Copyright John Wiley and Sons, Limited Nov 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4173-25366c76f6c2a35e2bac3b79c96bcaae3ccce5f926c967ae3c834e6f615b3e033</citedby><cites>FETCH-LOGICAL-c4173-25366c76f6c2a35e2bac3b79c96bcaae3ccce5f926c967ae3c834e6f615b3e033</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fgps.3943$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fgps.3943$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27774733$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23447432$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pimontel, Monique A.</creatorcontrib><creatorcontrib>Reinlieb, Michelle E.</creatorcontrib><creatorcontrib>Johnert, Lauren C.</creatorcontrib><creatorcontrib>Garcon, Ernst</creatorcontrib><creatorcontrib>Sneed, Joel R.</creatorcontrib><creatorcontrib>Roose, Steven P.</creatorcontrib><title>The external validity of MRI-defined vascular depression</title><title>International journal of geriatric psychiatry</title><addtitle>Int J Geriatr Psychiatry</addtitle><description>Objective
Multiple diagnostic criteria have been used to define vascular depression (VD). As a result, there are discrepancies in the clinical characteristics that have been established for the illness. The aim of this study was twofold. First, we used empirically established diagnostic criteria to determine the clinical characteristics of magnetic resonance imaging (MRI)‐defined VD. Second, we assessed the agreement between a quantitative and qualitative method for identifying the illness.
Method
We examined the baseline clinical and neuropsychological profile of 38 patients from a larger, double‐blind, randomized, 12‐week clinical trial comparing nortriptyline with sertraline in depressed older adults. Ten patients met quantitative criteria for MRI‐defined VD based on the highest quartile of deep white matter hyperintensity (DWMH) volume. Fourteen patients met qualitative criteria for MRI‐defined VD based on a DWMH score of 2 or higher on the Fazekas' modified Coffey rating scale.
Results
Age, gender, cumulative illness rating scale‐geriatric (CIRS‐G) score, two measures of psychomotor retardation [the psychomotor retardation item of the Hamilton Rating Scale for Depression (HRSD) as well as performance on the Purdue Pegboard], and performance on the Stroop Color/Word test (a measure of the response inhibition component of executive functioning) were significantly different between those with VD and non‐VD.
Conclusions
Patients with VD have a distinct clinical and neuropsychological profile that is mostly consistent across different methods for identifying the illness. These findings support the notion that MRI‐defined VD represents a unique and valid subtype of late‐life depression. Copyright © 2013 John Wiley & Sons, Ltd.</description><subject>Age Factors</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Antidepressive Agents - therapeutic use</subject><subject>Biological and medical sciences</subject><subject>Cerebrovascular Disorders - diagnosis</subject><subject>Cerebrovascular Disorders - physiopathology</subject><subject>clinical characteristics</subject><subject>Comparative analysis</subject><subject>Depressive Disorder - diagnosis</subject><subject>Depressive Disorder - drug therapy</subject><subject>Depressive Disorder - physiopathology</subject><subject>Double-Blind Method</subject><subject>external validity</subject><subject>Female</subject><subject>General aspects</subject><subject>Geriatric Assessment - methods</subject><subject>Geriatric psychiatry</subject><subject>Geriatric psychology</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>late-life depression</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Medical sciences</subject><subject>Mental depression</subject><subject>Middle Aged</subject><subject>Miscellaneous</subject><subject>MRI</subject><subject>Neuropsychological Tests</subject><subject>Neuropsychology</subject><subject>NMR</subject><subject>Nortriptyline - therapeutic use</subject><subject>Nuclear magnetic resonance</subject><subject>Psychiatric Status Rating Scales</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychomotor Performance - physiology</subject><subject>Psychopathology. Psychiatry</subject><subject>Public health. Hygiene</subject><subject>Public health. Hygiene-occupational medicine</subject><subject>Qualitative research</subject><subject>Reproducibility of Results</subject><subject>Sertraline - therapeutic use</subject><subject>Sex Factors</subject><subject>vascular depression</subject><issn>0885-6230</issn><issn>1099-1166</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10F1LHDEUBuBQKnW1BX9BGSiCN6NJTiaZuSx-rJZVi27xMmQyZ9rY2Zk12VH335upo0LBq5CTh_eQl5AdRvcZpfzg9zLsQyHgA5kwWhQpY1J-JBOa51kqOdBNshXCLaXxjeWfyCYHIZQAPiH5_A8m-LhC35omuTeNq9xqnXR1cn51llZYuxarOA-2b4xPKlx6DMF17WeyUZsm4Jfx3Ca_To7nh6fp7HJ6dvh9llrBFKQ8AymtkrW03ECGvDQWSlXYQpbWGARrLWZ1wWWcqOGeg8DIWVYCUoBtsvecu_TdXY9hpRcuWGwa02LXB82EAMhzRbNIv_1Hb7t--Nc_xYAxyvlboPVdCB5rvfRuYfxaM6qHNnVsUw9tRvp1DOzLBVav8KW-CHZHEAsyTe1Na114c0opoWAISp_dg2tw_e5CPf15PS4evQsrfHz1xv_VUoHK9M3FVM_E-Q86PZrrU3gCosqYYA</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Pimontel, Monique A.</creator><creator>Reinlieb, Michelle E.</creator><creator>Johnert, Lauren C.</creator><creator>Garcon, Ernst</creator><creator>Sneed, Joel R.</creator><creator>Roose, Steven P.</creator><general>Blackwell Publishing Ltd</general><general>Psychology Press</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>The external validity of MRI-defined vascular depression</title><author>Pimontel, Monique A. ; Reinlieb, Michelle E. ; Johnert, Lauren C. ; Garcon, Ernst ; Sneed, Joel R. ; Roose, Steven P.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4173-25366c76f6c2a35e2bac3b79c96bcaae3ccce5f926c967ae3c834e6f615b3e033</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Age Factors</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Antidepressive Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Cerebrovascular Disorders - diagnosis</topic><topic>Cerebrovascular Disorders - physiopathology</topic><topic>clinical characteristics</topic><topic>Comparative analysis</topic><topic>Depressive Disorder - diagnosis</topic><topic>Depressive Disorder - drug therapy</topic><topic>Depressive Disorder - physiopathology</topic><topic>Double-Blind Method</topic><topic>external validity</topic><topic>Female</topic><topic>General aspects</topic><topic>Geriatric Assessment - methods</topic><topic>Geriatric psychiatry</topic><topic>Geriatric psychology</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>late-life depression</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Medical sciences</topic><topic>Mental depression</topic><topic>Middle Aged</topic><topic>Miscellaneous</topic><topic>MRI</topic><topic>Neuropsychological Tests</topic><topic>Neuropsychology</topic><topic>NMR</topic><topic>Nortriptyline - therapeutic use</topic><topic>Nuclear magnetic resonance</topic><topic>Psychiatric Status Rating Scales</topic><topic>Psychology. Psychoanalysis. Psychiatry</topic><topic>Psychomotor Performance - physiology</topic><topic>Psychopathology. Psychiatry</topic><topic>Public health. Hygiene</topic><topic>Public health. Hygiene-occupational medicine</topic><topic>Qualitative research</topic><topic>Reproducibility of Results</topic><topic>Sertraline - therapeutic use</topic><topic>Sex Factors</topic><topic>vascular depression</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pimontel, Monique A.</creatorcontrib><creatorcontrib>Reinlieb, Michelle E.</creatorcontrib><creatorcontrib>Johnert, Lauren C.</creatorcontrib><creatorcontrib>Garcon, Ernst</creatorcontrib><creatorcontrib>Sneed, Joel R.</creatorcontrib><creatorcontrib>Roose, Steven P.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International journal of geriatric psychiatry</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pimontel, Monique A.</au><au>Reinlieb, Michelle E.</au><au>Johnert, Lauren C.</au><au>Garcon, Ernst</au><au>Sneed, Joel R.</au><au>Roose, Steven P.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The external validity of MRI-defined vascular depression</atitle><jtitle>International journal of geriatric psychiatry</jtitle><addtitle>Int J Geriatr Psychiatry</addtitle><date>2013-11</date><risdate>2013</risdate><volume>28</volume><issue>11</issue><spage>1189</spage><epage>1196</epage><pages>1189-1196</pages><issn>0885-6230</issn><eissn>1099-1166</eissn><coden>IJGPES</coden><abstract>Objective
Multiple diagnostic criteria have been used to define vascular depression (VD). As a result, there are discrepancies in the clinical characteristics that have been established for the illness. The aim of this study was twofold. First, we used empirically established diagnostic criteria to determine the clinical characteristics of magnetic resonance imaging (MRI)‐defined VD. Second, we assessed the agreement between a quantitative and qualitative method for identifying the illness.
Method
We examined the baseline clinical and neuropsychological profile of 38 patients from a larger, double‐blind, randomized, 12‐week clinical trial comparing nortriptyline with sertraline in depressed older adults. Ten patients met quantitative criteria for MRI‐defined VD based on the highest quartile of deep white matter hyperintensity (DWMH) volume. Fourteen patients met qualitative criteria for MRI‐defined VD based on a DWMH score of 2 or higher on the Fazekas' modified Coffey rating scale.
Results
Age, gender, cumulative illness rating scale‐geriatric (CIRS‐G) score, two measures of psychomotor retardation [the psychomotor retardation item of the Hamilton Rating Scale for Depression (HRSD) as well as performance on the Purdue Pegboard], and performance on the Stroop Color/Word test (a measure of the response inhibition component of executive functioning) were significantly different between those with VD and non‐VD.
Conclusions
Patients with VD have a distinct clinical and neuropsychological profile that is mostly consistent across different methods for identifying the illness. These findings support the notion that MRI‐defined VD represents a unique and valid subtype of late‐life depression. Copyright © 2013 John Wiley & Sons, Ltd.</abstract><cop>Hove</cop><pub>Blackwell Publishing Ltd</pub><pmid>23447432</pmid><doi>10.1002/gps.3943</doi><tpages>8</tpages></addata></record> |
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subjects | Age Factors Aged Aged, 80 and over Antidepressive Agents - therapeutic use Biological and medical sciences Cerebrovascular Disorders - diagnosis Cerebrovascular Disorders - physiopathology clinical characteristics Comparative analysis Depressive Disorder - diagnosis Depressive Disorder - drug therapy Depressive Disorder - physiopathology Double-Blind Method external validity Female General aspects Geriatric Assessment - methods Geriatric psychiatry Geriatric psychology Geriatrics Humans late-life depression Magnetic Resonance Imaging Male Medical sciences Mental depression Middle Aged Miscellaneous MRI Neuropsychological Tests Neuropsychology NMR Nortriptyline - therapeutic use Nuclear magnetic resonance Psychiatric Status Rating Scales Psychology. Psychoanalysis. Psychiatry Psychomotor Performance - physiology Psychopathology. Psychiatry Public health. Hygiene Public health. Hygiene-occupational medicine Qualitative research Reproducibility of Results Sertraline - therapeutic use Sex Factors vascular depression |
title | The external validity of MRI-defined vascular depression |
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