Thyrotropin Secretion Patterns in Health and Disease
Thyroid hormones are extremely important for metabolism, development, and growth during the lifetime. The hypothalamo-pituitary-thyroid axis is precisely regulated for these purposes. Much of our knowledge of this hormonal axis is derived from experiments in animals and mutations in man. This review...
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| Veröffentlicht in: | Endocrine reviews 2013-10, Vol.34 (5), p.619-657 |
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| creator | Roelfsema, Ferdinand Veldhuis, Johannes D |
| description | Thyroid hormones are extremely important for metabolism, development, and growth during the lifetime. The hypothalamo-pituitary-thyroid axis is precisely regulated for these purposes. Much of our knowledge of this hormonal axis is derived from experiments in animals and mutations in man. This review examines the hypothalamo-pituitary-thyroid axis particularly in relation to the regulated 24-hour serum TSH concentration profiles in physiological and pathophysiological conditions, including obesity, primary hypothyroidism, pituitary diseases, psychiatric disorders, and selected neurological diseases. Diurnal TSH rhythms can be analyzed with novel and precise techniques, eg, operator-independent deconvolution and approximate entropy. These approaches provide indirect insight in the regulatory components in pathophysiological conditions. |
| doi_str_mv | 10.1210/er.2012-1076 |
| format | Article |
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The hypothalamo-pituitary-thyroid axis is precisely regulated for these purposes. Much of our knowledge of this hormonal axis is derived from experiments in animals and mutations in man. This review examines the hypothalamo-pituitary-thyroid axis particularly in relation to the regulated 24-hour serum TSH concentration profiles in physiological and pathophysiological conditions, including obesity, primary hypothyroidism, pituitary diseases, psychiatric disorders, and selected neurological diseases. Diurnal TSH rhythms can be analyzed with novel and precise techniques, eg, operator-independent deconvolution and approximate entropy. 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| ispartof | Endocrine reviews, 2013-10, Vol.34 (5), p.619-657 |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Journals@Ovid Complete; Oxford University Press Journals All Titles (1996-Current); Alma/SFX Local Collection |
| subjects | Adult Animals Circadian Rhythm Female Health Status Hormones Humans Hypothalamo-Hypophyseal System - physiopathology Hypothyroidism Hypothyroidism - physiopathology Infant, Newborn Male Mental disorders Mental Disorders - physiopathology Middle Aged Nervous System Diseases - physiopathology Neurological diseases Obesity - physiopathology Pituitary Pituitary Diseases - physiopathology Pregnancy Sex Factors Thyroid Thyroid Diseases - physiopathology Thyroid Gland - physiopathology Thyroid Hormone Resistance Syndrome - physiopathology Thyroid hormones Thyroid-stimulating hormone Thyrotropin - blood Thyrotropin - secretion Thyroxine - blood Triiodothyronine - blood |
| title | Thyrotropin Secretion Patterns in Health and Disease |
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