Perifosine, an AKT inhibitor, modulates ovarian cancer cell line sensitivity to cisplatin-induced growth arrest

Abstract Objectives AKT, a key regulator of diverse tumor signaling, is associated with progression of many cancers. Here, we investigated 1) the influence of AKT on survival from ovarian cancer (OVCA), 2) the activity of the AKT inhibitor perifosine ± cisplatin, and 3) the molecular determinants of...

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Veröffentlicht in:	Gynecologic oncology 2013-10, Vol.131 (1), p.207-212
Hauptverfasser:	Al Sawah, Entidhar, Chen, Xin, Marchion, Douglas C, Xiong, Yin, Ramirez, Ingrid J, Abbasi, Forough, Bou Zgheib, Nadim, Chon, Hye Sook, Wenham, Robert M, Apte, Sachin M, Judson, Patricia L, Lancaster, Johnathan M
Format:	Artikel
Sprache:	eng
Schlagworte:	AKT Antineoplastic Agents - pharmacology Carcinoma, Ovarian Epithelial Cell Line, Tumor Cell Survival - drug effects Cisplatin Cisplatin - pharmacology Gene expression Hematology, Oncology and Palliative Medicine Humans Neoplasms, Glandular and Epithelial - drug therapy Obstetrics and Gynecology Oligonucleotide Array Sequence Analysis Ovarian CANCER Ovarian Neoplasms - drug therapy Perifosine Phosphorylation Phosphorylcholine - analogs & derivatives Phosphorylcholine - pharmacology Proto-Oncogene Proteins c-akt - antagonists & inhibitors Proto-Oncogene Proteins c-akt - metabolism RNA - analysis Signal Transduction - drug effects
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