A Review of the Medical Treatment of Pediatric Glaucomas at Moorfields Eye Hospital
PURPOSE:To report on the medical treatments used for pediatric glaucomas. PATIENTS AND METHODS:A retrospective case series consisting of reviewing the medical notes of pediatric glaucoma patients under the care of the Glaucoma Service at Moorfields Eye Hospital NHS Foundation Trust. The medical note...
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| Veröffentlicht in: | Journal of glaucoma 2013-10, Vol.22 (8), p.601-607 |
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| container_title | Journal of glaucoma |
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| creator | Chang, Lydia Ong, Ee Lin Bunce, Catey Brookes, John Papadopoulos, Maria Khaw, Peng Tee |
| description | PURPOSE:To report on the medical treatments used for pediatric glaucomas.
PATIENTS AND METHODS:A retrospective case series consisting of reviewing the medical notes of pediatric glaucoma patients under the care of the Glaucoma Service at Moorfields Eye Hospital NHS Foundation Trust. The medical notes of 200 patients were selected. The following outcomes were assessed(1) the use of individual medical therapies; (2) the intraocular pressure (IOP) reduction effect of individual medicines; (3) the reporting of side effects.
RESULTS:Medicines were prescribed 1592 times (200 patients). The median % IOP reduction for latanoprost 50 mcg/mL was −17.2% and for the topical beta blockers was −17.7% (as monotherapy), with no statistical difference in IOP-lowering effect between all the medicines (P=0.19). Side effects were reported in 19.5% of all patients—the highest occurrence with brimonidine tartrate 0.2% (in 17% patients) and the lowest occurrence with the prostaglandin analogue and prostamide medicines (in 3.8% patients). The combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence of 1 year.
CONCLUSIONS:The IOP-lowering effects of all the glaucoma medicines were not significantly different although the combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence. |
| doi_str_mv | 10.1097/IJG.0b013e31824d1e2f |
| format | Article |
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PATIENTS AND METHODS:A retrospective case series consisting of reviewing the medical notes of pediatric glaucoma patients under the care of the Glaucoma Service at Moorfields Eye Hospital NHS Foundation Trust. The medical notes of 200 patients were selected. The following outcomes were assessed(1) the use of individual medical therapies; (2) the intraocular pressure (IOP) reduction effect of individual medicines; (3) the reporting of side effects.
RESULTS:Medicines were prescribed 1592 times (200 patients). The median % IOP reduction for latanoprost 50 mcg/mL was −17.2% and for the topical beta blockers was −17.7% (as monotherapy), with no statistical difference in IOP-lowering effect between all the medicines (P=0.19). Side effects were reported in 19.5% of all patients—the highest occurrence with brimonidine tartrate 0.2% (in 17% patients) and the lowest occurrence with the prostaglandin analogue and prostamide medicines (in 3.8% patients). The combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence of 1 year.
CONCLUSIONS:The IOP-lowering effects of all the glaucoma medicines were not significantly different although the combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence.</description><identifier>ISSN: 1057-0829</identifier><identifier>EISSN: 1536-481X</identifier><identifier>DOI: 10.1097/IJG.0b013e31824d1e2f</identifier><identifier>PMID: 22411019</identifier><language>eng</language><publisher>United States: by Lippincott Williams & Wilkins</publisher><subject>Adolescent ; Antihypertensive Agents - adverse effects ; Antihypertensive Agents - therapeutic use ; Child ; Child, Preschool ; Drug Prescriptions - statistics & numerical data ; Female ; Glaucoma - drug therapy ; Hospitals, Special ; Humans ; Infant ; Infant, Newborn ; Intraocular Pressure - drug effects ; Male ; Ophthalmic Solutions ; Ophthalmology ; Retrospective Studies ; Tonometry, Ocular</subject><ispartof>Journal of glaucoma, 2013-10, Vol.22 (8), p.601-607</ispartof><rights>2013 by Lippincott Williams & Wilkins.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c468f-aa1d2d5a1d1ae9ab56d8aaace131a5e418959f053f5145621c32a6848344290f3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22411019$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Chang, Lydia</creatorcontrib><creatorcontrib>Ong, Ee Lin</creatorcontrib><creatorcontrib>Bunce, Catey</creatorcontrib><creatorcontrib>Brookes, John</creatorcontrib><creatorcontrib>Papadopoulos, Maria</creatorcontrib><creatorcontrib>Khaw, Peng Tee</creatorcontrib><title>A Review of the Medical Treatment of Pediatric Glaucomas at Moorfields Eye Hospital</title><title>Journal of glaucoma</title><addtitle>J Glaucoma</addtitle><description>PURPOSE:To report on the medical treatments used for pediatric glaucomas.
PATIENTS AND METHODS:A retrospective case series consisting of reviewing the medical notes of pediatric glaucoma patients under the care of the Glaucoma Service at Moorfields Eye Hospital NHS Foundation Trust. The medical notes of 200 patients were selected. The following outcomes were assessed(1) the use of individual medical therapies; (2) the intraocular pressure (IOP) reduction effect of individual medicines; (3) the reporting of side effects.
RESULTS:Medicines were prescribed 1592 times (200 patients). The median % IOP reduction for latanoprost 50 mcg/mL was −17.2% and for the topical beta blockers was −17.7% (as monotherapy), with no statistical difference in IOP-lowering effect between all the medicines (P=0.19). Side effects were reported in 19.5% of all patients—the highest occurrence with brimonidine tartrate 0.2% (in 17% patients) and the lowest occurrence with the prostaglandin analogue and prostamide medicines (in 3.8% patients). The combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence of 1 year.
CONCLUSIONS:The IOP-lowering effects of all the glaucoma medicines were not significantly different although the combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence.</description><subject>Adolescent</subject><subject>Antihypertensive Agents - adverse effects</subject><subject>Antihypertensive Agents - therapeutic use</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Drug Prescriptions - statistics & numerical data</subject><subject>Female</subject><subject>Glaucoma - drug therapy</subject><subject>Hospitals, Special</subject><subject>Humans</subject><subject>Infant</subject><subject>Infant, Newborn</subject><subject>Intraocular Pressure - drug effects</subject><subject>Male</subject><subject>Ophthalmic Solutions</subject><subject>Ophthalmology</subject><subject>Retrospective Studies</subject><subject>Tonometry, Ocular</subject><issn>1057-0829</issn><issn>1536-481X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kEtP7DAMhSME4v0P0FWWbApxHiVdIsSdAYFAPCR2lad1NIWUDEl6R_x7igbuggUb27LPOZY-xg5AHIGoTo4vLidHYiZAkQIrdQsk3RrbBqPKQlt4Wh9nYU4KYWW1xXZSehZCCilhk21JqQEEVNvs_pTf0b-Oljw4nufEr6ntGvT8IRLmnl7z5-F2XGKOXcMnHocm9Jg4Zn4dQnQd-Tbx83fi05AWXUa_xzYc-kT7X32XPf49fzibFlc3k4uz06ui0aV1BSK0sjVjBaQKZ6ZsLSI2BArQkAZbmcoJo5wBbUoJjZJYWm2V1rISTu2yw1XuIoa3gVKu-y415D2-UhhSDVorZU2pYZTqlbSJIaVIrl7Ersf4XoOoP3HWI876J87R9ufrwzDrqf1v-uY3CuxKsAw-U0wvflhSrOeEPs9_z_4Ae0CC7g</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Chang, Lydia</creator><creator>Ong, Ee Lin</creator><creator>Bunce, Catey</creator><creator>Brookes, John</creator><creator>Papadopoulos, Maria</creator><creator>Khaw, Peng Tee</creator><general>by Lippincott Williams & Wilkins</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201310</creationdate><title>A Review of the Medical Treatment of Pediatric Glaucomas at Moorfields Eye Hospital</title><author>Chang, Lydia ; Ong, Ee Lin ; Bunce, Catey ; Brookes, John ; Papadopoulos, Maria ; Khaw, Peng Tee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c468f-aa1d2d5a1d1ae9ab56d8aaace131a5e418959f053f5145621c32a6848344290f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adolescent</topic><topic>Antihypertensive Agents - adverse effects</topic><topic>Antihypertensive Agents - therapeutic use</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Drug Prescriptions - statistics & numerical data</topic><topic>Female</topic><topic>Glaucoma - drug therapy</topic><topic>Hospitals, Special</topic><topic>Humans</topic><topic>Infant</topic><topic>Infant, Newborn</topic><topic>Intraocular Pressure - drug effects</topic><topic>Male</topic><topic>Ophthalmic Solutions</topic><topic>Ophthalmology</topic><topic>Retrospective Studies</topic><topic>Tonometry, Ocular</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chang, Lydia</creatorcontrib><creatorcontrib>Ong, Ee Lin</creatorcontrib><creatorcontrib>Bunce, Catey</creatorcontrib><creatorcontrib>Brookes, John</creatorcontrib><creatorcontrib>Papadopoulos, Maria</creatorcontrib><creatorcontrib>Khaw, Peng Tee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of glaucoma</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chang, Lydia</au><au>Ong, Ee Lin</au><au>Bunce, Catey</au><au>Brookes, John</au><au>Papadopoulos, Maria</au><au>Khaw, Peng Tee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A Review of the Medical Treatment of Pediatric Glaucomas at Moorfields Eye Hospital</atitle><jtitle>Journal of glaucoma</jtitle><addtitle>J Glaucoma</addtitle><date>2013-10</date><risdate>2013</risdate><volume>22</volume><issue>8</issue><spage>601</spage><epage>607</epage><pages>601-607</pages><issn>1057-0829</issn><eissn>1536-481X</eissn><abstract>PURPOSE:To report on the medical treatments used for pediatric glaucomas.
PATIENTS AND METHODS:A retrospective case series consisting of reviewing the medical notes of pediatric glaucoma patients under the care of the Glaucoma Service at Moorfields Eye Hospital NHS Foundation Trust. The medical notes of 200 patients were selected. The following outcomes were assessed(1) the use of individual medical therapies; (2) the intraocular pressure (IOP) reduction effect of individual medicines; (3) the reporting of side effects.
RESULTS:Medicines were prescribed 1592 times (200 patients). The median % IOP reduction for latanoprost 50 mcg/mL was −17.2% and for the topical beta blockers was −17.7% (as monotherapy), with no statistical difference in IOP-lowering effect between all the medicines (P=0.19). Side effects were reported in 19.5% of all patients—the highest occurrence with brimonidine tartrate 0.2% (in 17% patients) and the lowest occurrence with the prostaglandin analogue and prostamide medicines (in 3.8% patients). The combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence of 1 year.
CONCLUSIONS:The IOP-lowering effects of all the glaucoma medicines were not significantly different although the combination of dorzolamide hydrochloride 2%, timolol maleate 0.5% had the greatest persistence.</abstract><cop>United States</cop><pub>by Lippincott Williams & Wilkins</pub><pmid>22411019</pmid><doi>10.1097/IJG.0b013e31824d1e2f</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Journal of glaucoma, 2013-10, Vol.22 (8), p.601-607 |
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| source | MEDLINE; Journals@Ovid Complete |
| subjects | Adolescent Antihypertensive Agents - adverse effects Antihypertensive Agents - therapeutic use Child Child, Preschool Drug Prescriptions - statistics & numerical data Female Glaucoma - drug therapy Hospitals, Special Humans Infant Infant, Newborn Intraocular Pressure - drug effects Male Ophthalmic Solutions Ophthalmology Retrospective Studies Tonometry, Ocular |
| title | A Review of the Medical Treatment of Pediatric Glaucomas at Moorfields Eye Hospital |
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