Anthocyanin determination in blueberry extracts from various cultivars and their antiproliferative and apoptotic properties in B16-F10 metastatic murine melanoma cells

A crude methanolic extract was obtained from fresh blueberries of each seven cultivars tested. The crude extract was then purified over an Amberlite XAD-7 resin and a Sephadex LH-20 column, in order to obtain the anthocyanin rich fraction (ARF). High performance liquid chromatography followed by ele...

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Veröffentlicht in:	Phytochemistry (Oxford) 2013-11, Vol.95, p.436-444
Hauptverfasser:	Bunea, Andrea, Rugină, Dumitriţa, Sconţa, Zoriţa, Pop, Raluca M., Pintea, Adela, Socaciu, Carmen, Tăbăran, Flaviu, Grootaert, Charlotte, Struijs, Karin, VanCamp, John
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anthocyanins Anthocyanins - isolation & purification Anthocyanins - pharmacology Anthocyanins - therapeutic use Antineoplastic Agents, Phytogenic - isolation & purification Antineoplastic Agents, Phytogenic - pharmacology Antineoplastic Agents, Phytogenic - therapeutic use antioxidant activity Antioxidants - isolation & purification Antioxidants - pharmacology Antioxidants - therapeutic use Apoptosis Apoptosis - drug effects blueberries Blueberry extracts Blueberry Plants - chemistry Cell culture Cell Proliferation - drug effects chemoprevention cultivars electrospray ionization mass spectrometry Glucosides - isolation & purification Glucosides - pharmacology Glucosides - therapeutic use high performance liquid chromatography L-Lactate Dehydrogenase - metabolism melanoma Melanoma, Experimental - drug therapy Melanoma, Experimental - metabolism metastasis Mice Phytotherapy Plant Extracts - pharmacology Plant Extracts - therapeutic use Species Specificity
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