Size effect of amphiphilic poly(γ-glutamic acid) nanoparticles on cellular uptake and maturation of dendritic cells in vivo

The size of NPs significantly influenced the uptake and activation behaviors of antigen presenting cells (APCs) in vitro and in vivo. We prepared size-regulated nanoparticles (NPs) composed of amphiphilic poly(γ-glutamic acid) (γ-PGA). In this study, 40, 100 and 200nm γ-PGA-graft-l-phenylalanine eth...

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Veröffentlicht in:	Acta biomaterialia 2013-11, Vol.9 (11), p.8894-8901
Hauptverfasser:	Shima, Fumiaki, Uto, Tomofumi, Akagi, Takami, Baba, Masanori, Akashi, Mitsuru
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals antigens Cell Death - drug effects Cell Differentiation - drug effects Cell Line Dendritic cells Dendritic Cells - cytology Dendritic Cells - drug effects Dendritic Cells - metabolism Endocytosis - drug effects Female Lymph nodes Macrophage Activation - drug effects Macrophages - cytology Macrophages - drug effects Macrophages - metabolism Mice Mice, Inbred C57BL Nanoparticles Nanoparticles - chemistry Particle Size Polyglutamic Acid - analogs & derivatives Polyglutamic Acid - chemical synthesis Polyglutamic Acid - chemistry Polyglutamic Acid - pharmacology Staining and Labeling Surface-Active Agents - chemistry Vaccine
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